Substance P blockade effects on peripheral blood leukocytic reaction in secondary chronic inflammation

Abstract

In an experimental prospective controlled study the leukocyte response of peripheral blood on the background of blockade of receptors of substance P was studied on the carrageenan model of secondary chronic inflammation in 132 rats. Compared with the natural course of inflammation, at 6 hours there was a significant decrease in total white blood cells count by 1.28 (p<0.05), as well as a significant decrease in the number of polymorphonuclear neutrophils by 4 times (p<0.05) and the number of eosinophils by 3 times (p<0.05) by 10 days. On day 28, there was a significant increase in the number of monocytes in 2 times (p<0,01). The results of the study indicate that in natural conditions of inflammation, substance P stimulates blood leukocytes, as well as prolongs the inflammatory response, and its blocking helps to reduce the inflammatory response.