Substance P and Hemokinin 1 in Nasal Lavage Fluid of Patients with Chronic Sinusitis and Nasal Polyposis

Lonergan, Ashley R.; Theoharides, Theoharis C.; Tsilioni, Eirini; Rebeiz, Elie E.

doi:10.1177/2473974x19875076

Cited by 5 publications

(23 citation statements)

References 17 publications

(25 reference statements)

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“…Кроме того, секретировать данный медиатор способны некоторые клеточные элементы иммунной системы (макрофаги, лимфоциты). Вещество Р способствует повышению выработки слизи на всем протяжении дыхательных путей, активирует тучные клетки, вызывает их дегрануляцию и выделение гистамина, индуцирует хемотаксис моноцитов, нейтрофилов и эозинофилов, стимулирует макрофаги для дальнейшего производства медиаторов воспаления и цитокинов [11,12]. Его рецепторы (нейрокининовые рецепторы типа 1, NK1) обнаруживаютcя на поверхности иммунопозитивных элементов воспалительных инфильтратов, на эпителии и железистых эпителиоцитах, на эндотелиальных и гладкомышечных клетках сосудов.…”

Section: Discussionunclassified

“…Его рецепторы (нейрокининовые рецепторы типа 1, NK1) обнаруживаютcя на поверхности иммунопозитивных элементов воспалительных инфильтратов, на эпителии и железистых эпителиоцитах, на эндотелиальных и гладкомышечных клетках сосудов. Активация NК1 рецепторов увеличивает вазодилатацию, межтканевой отек в полости носа что приводит к затруднению воздухообмена в верхних дыхательных путях [5,11,13].…”

Section: Discussionunclassified

“…Можно предположить, что повышенная активность SP способствует перестройке ткани СО носа и провоцирует процесс полипообразования, который поддерживается феноменом нейрогенного воспаления. Подтверждением этому является изобилие SP-позитивных клеточных элементов в составе воспалительных инфильтратов, наблюдаемых в полипозно измененных тканях [11][12][13].…”

Section: Discussionunclassified

“…Уменьшение его актив ности в стенках кровеносных сосудов и нарастание NK1 в клеточных элементах лимфоидных инфильтратов, покровного и железистого эпителия можно рассматривать как предпосылки к развитию пролиферативного процесса и активации сигнальных каскадов, поступающих через мембрану клеток однослойного многорядного мерцательного эпителия. Индуцируемое нейрокининами увеличение секреции в железах, повышение сосудистой проницаемости, экстравазация плазмы крови и развитие нейрогенного воспаления могут способствовать прогрессированию отечных и воспалительных изменений в СО полости носа [11,13,15].…”

Section: Discussionunclassified

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Inflammatory markers in the nasal mucosa and polyp-modified tissues in chronic rhinosinusitis with nasal polyps

Павлуш¹,

Dyuizen²

2021

Clin. Exp. Morphology

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Introduction. To date, chronic rhinosinusitis with nasal polyps (CRSwNP) has not yet been extensively studied: the molecular factors and mechanisms involved in the initiation of polypous transformations in nasal mucosa (NM) and sustaining their recurrence probability are still to be determined. Simultaneously, it is necessary to understand the molecular rearrangement in NM tissues to make clinical prognosis and choose an adequate therapeutic or surgical strategy for CRSwNP treatment. The aim of the study was to identify the features of how inflammatory markers localize and are distributed in the NM and polyps in various morphological CRSwNP types. Materials and methods. We studied morphological and chemical structure of nasal polyps and mucosa of the inferior turbinates. The material was obtained during surgical management of patients diagnosed with CRSwNP. The comparison group involved the patients with a deviated septum who underwent septorhi-noplasty and had neither polyposis nor concomitant inflammatory/allergic pathology. The NM removed in surgeries was used to compare morphological and chemical changes. Immunohistochemistry was applied to determine the localization and distribution of SP, NK1, nNOS, iNOS, and IL1b in the tissues. Results. The formation of nasal polyps was found to be accompanied by morphological and chemical altera-tions in the mucous membrane of the inferior turbinates. In polyps of different morphological types, the changes in the activity of inflammatory markers were specific. Conclusion. The data obtained indicate that changes in the NM of the inferior turbinates, which accompany polyposis development, give certain pathological causes that induce and maintain the pathological process. We have revealed the features of the specific signaling microenvironment in the nasal cavity, which provide special conditions for the formation of polyps of various types. The specificity of the activity and distribu-tion of inflammatory markers in the polyps of different morphological types may serve as a prerequisite for the development of personalized therapy for the disease. Keywords: chronic rhinosinusitis with nasal polyps, inflammation, neurokinin receptors, substance P, nitric oxide

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Section: Discussionunclassified

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Inflammatory markers in the nasal mucosa and polyp-modified tissues in chronic rhinosinusitis with nasal polyps

Павлуш¹,

Dyuizen²

2021

Clin. Exp. Morphology

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“…Data in the literature range from the suggestion that NP are primarily caused by neurogenic inflammation to the claim that due to the poor sensory innervation of NPs, neurogenic inflammation is completely absent 5,6 . However, recent studies related to releasing of neuropeptides in nasal secretions, especially SP and BK, and monitoring their immunoexpression in NP tissue, clearly suggest that neurogenic inflammation plays a significant role in the pathogenesis of NP 7–9 …”

Section: Introductionmentioning

confidence: 99%

Evaluation of substance P and bradykinin levels in nasal secretions of patients with nasal polyposis with and without sensitivity to non‐steroidal anti‐inflammatory drugs

Perić

Matkovic

Barać

et al. 2022

Laryngoscope Investig Oto

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Objective: The role of neurogenic inflammation in pathogenesis of chronic rhinitis is well known. However, very little is known about its importance in pathogenesis of nasal polyposis (NP), especially in form of NP which appears as a part of aspirinexacerbated respiratory disease (AERD). The aim of this study was to examine the concentrations of neuropeptides substance P (SP) and bradykinin (BK) in nasal secretions of patients with NP.Methods: Fourteen patients with NP as a part of AERD with mild persistent asthma, 14 patients with NP without aspirin sensitivity, and 14 control subjects without nasal inflammation (C) entered this cross-sectional study. Clinical parameters (symptoms, endoscopic, and radiological findings) were assessed. The concentrations of SP and BK were measured in the nasal secretion samples using commercial human enzyme immunoassay kits. Results:The concentration of SP in nasal secretions was significantly higher in NP patients without aspirin sensitivity and AERD patients compared to controls (p = .022; p < .0001, respectively), but higher in AERD than in non-AERD patients (p = .018). The level of BK in nasal fluid was higher in non-AERD and AERD NP patients than in controls (p < .0001; p < .0001, respectively), but also higher in AERD than in non-AERD patients (p < .0001). We found high positive correlations between BK in nasal fluid and Lund-Mackay computed tomography (CT) score in both non-AERD and AERD groups of NP patients. Conclusion:Our results suggest more intense release of SP and BK from the nasal mucosa in patients with AERD than in patients with NP who do not have aspirin sensitivity. The strong correlation between concentration of BK in nasal secretions and CT score suggests that BK in nasal fluid could be used as a marker for disease severity as measured by the Lund-Mackay score.

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Inflammatory mediators in nasal secretions of patients with nasal polyposis with and without aspirin sensitivity

Perić

Gaćeša²,

Cvetković

et al. 2023

Immunity Inflam & Disease

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Background: The aim of this cross-sectional study was to compare the levels of inflammatory mediators in nasal secretions in patients with aspirinexacerbated respiratory disease (AERD) and in those with nasal polyposis (NP) without aspirin-sensitivity and to correlate nasal fluid mediator concentrations with clinical parameters of the disease.Methods: A total of 30 patients with AERD, 30 chronic rhinosinusitis (CRS) with NP patients without aspirin sensitivity (CRSwNP), and 30 control subjects without inflammation of the nasal mucosa (C), selected for surgical treatment entered the study. The total nasal symptom score (TNSS), endoscopic score (ES), and Lund-Mackay score (LMS), were evaluated. The concentrations of eosinophil cationic protein (ECP), tryptase, heat shock protein 70 (HSP70), substance P and Clara cell protein 16 (CC16) were determined in nasal secretions. Results: Higher concentrations of ECP, tryptase, and HSP70 were measured in the AERD patients than in the CRSwNP patients and the C group (p < .001; p < .001, respectively for all mediators). However, levels of CC16 were higher in the C group than in the AERD and CRSwNP groups (p < .001; p < .001, respectively). A positive correlation between the TNSS and CC16 and a negative one between CC16 and tryptase levels were found in the C group. The CRSwNP group showed positive correlations between ECP, HSP70, and tryptase and negative correlations between substance P, ES, and LMS, as well as between CC16 and tryptase levels. In the AERD group, we found a positive correlation between HSP70 and ECP levels and a negative correlation between the TNSS and CC16 concentration. Conclusion: The obtained results indicate the increased production of mediators of eosinophil and mast cell function, and the decreased production of biomarker of respiratory epithelial function in AERD patients. Clinical and biochemical parameters correlate in different ways in the AERD and CRSwNP patients.

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Substance P and Hemokinin 1 in Nasal Lavage Fluid of Patients with Chronic Sinusitis and Nasal Polyposis

Cited by 5 publications

References 17 publications

Inflammatory markers in the nasal mucosa and polyp-modified tissues in chronic rhinosinusitis with nasal polyps

Inflammatory markers in the nasal mucosa and polyp-modified tissues in chronic rhinosinusitis with nasal polyps

Evaluation of substance P and bradykinin levels in nasal secretions of patients with nasal polyposis with and without sensitivity to non‐steroidal anti‐inflammatory drugs

Inflammatory mediators in nasal secretions of patients with nasal polyposis with and without aspirin sensitivity

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