Substance P and Acute Pain in Patients Undergoing Orthopedic Surgery

Lisowska, Barbara; Siewruk, Katarzyna; Lisowski, A.

doi:10.1371/journal.pone.0146400

Cited by 20 publications

(18 citation statements)

References 15 publications

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“…SP levels were found clinically to be elevated following orthopedic surgery, with increasing levels of SP correlating with increasing levels of acute pain intensity (Lisowska et al, 2016). Previously, we found SP to be an endogenous agonist of Mrgprb2 (McNeil et al, 2015), so we tested whether SP injected into the hindpaws of mice was capable of recruiting innate immune cells.…”

Section: Substance P Promotes Innate Immune Cell Recruitment Via Actimentioning

confidence: 99%

A Mast-Cell-Specific Receptor Mediates Neurogenic Inflammation and Pain

Green

Limjunyawong

Gour

et al. 2019

Neuron

271

225

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Highlights d The mast cell receptor Mrgprb2 is required for neurogenic inflammatory pain d Substance P (SP) recruits immune cells via Mrgprb2 independent of the NK-1 receptor d SP activation of Mrgprb2 and its human ortholog MRGPRX2 releases cytokines d Mrgprb2/X2 is a target for treating pain SUMMARYMast cells can be found in close proximity to peripheral nerve endings where, upon activation, they release a broad range of pro-inflammatory cytokines and chemokines. However, the precise mechanism underlying this so-called neurogenic inflammation and associated pain has remained elusive. Here we report that the mast-cell-specific receptor Mrgprb2 mediates inflammatory mechanical and thermal hyperalgesia and is required for recruitment of innate immune cells at the injury site. We also found that the neuropeptide substance P (SP), an endogenous agonist of Mrgprb2, facilitates immune cells' migration via Mrgprb2. Furthermore, SP activation of the human mast cell led to the release of multiple pro-inflammatory cytokines and chemokines via the human homolog MRGPRX2. Surprisingly, the SP-mediated inflammatory responses were independent of its canonical receptor, neurokinin-1 receptor (NK-1R). These results identify Mrgprb2/X2 as an important neuroimmune modulator and a potential target for treating inflammatory pain.

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Section: Substance P Promotes Innate Immune Cell Recruitment Via Actimentioning

confidence: 99%

A Mast-Cell-Specific Receptor Mediates Neurogenic Inflammation and Pain

Green

Limjunyawong

Gour

et al. 2019

Neuron

271

225

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“…A decrease in the serum level of SP has not been reported previously. Previous study has suggested a positive correlation between the systemic SP level and pain nociception (11). Lisowska et al found that among patients with rheumatoid arthritis, the extent of pain after total knee arthroplasty was positively correlated with the serum level of SP (11).…”

Section: Discussionmentioning

confidence: 98%

Systemic effects after local injection of platelet-rich plasma: a prospective randomized study

Kuo¹,

Hsu²,

Chang-Chien³

et al. 2020

Preprint

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Background Platelet-rich plasma (PRP) is widely utilized in the treatment of sports injuries. However, potential systemic effects after localized PRP injection are unclear at present.Design: prospective randomized study Methods Twenty-four Taiwanese male athletes with tendinopathy were randomized into a PRP group (n = 13) or a saline group (n = 11).Results The results showed no significant differences in serum levels of growth hormone, insulin-like growth factor-1, insulin-like growth factor-binding protein 3, vascular endothelial growth factor, platelet-derived growth factor-BB, or serum substance P between the two groups at baseline, nor at 1, 2, or 7 days after intervention. However, a significant decrease in the serum substance P level 1 and 7 days after PRP injection was observed. Regarding urinary concentrations of metabolites of anabolic androgenic steroids (AAS), no between-group differences at baseline, nor at 1, 2, or 7 days after intervention, were observed. Conclusions Our study failed to observe significant surge of serum anabolic molecules and urinary excretion of anabolic AAS metabolites after PRP injection. Trial registration with ClinicalTrials.gov: NCT04456907

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“…Further research is required focusing on NMT's influence on biological and chemical injury agents, e.g., burns and postoperative conditions. P substance in serum is closely associated with the occurrence of acute pain (Blow, 2018;Lisowska et al, 2016), and further research is required on whether NMT can influence P substance. The development of NMT in the management of acute pain in cancer and postoperative care also requires further research, e.g., in terms of surgical wound care.…”

Section: Discussionmentioning

confidence: 99%

Neuromuscular taping application opportunities in nursing: a literature review

Kristianto¹,

Waluyo²,

Yunir³

et al. 2020

Cent Eur J Nurs Midw

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Aim: This study aims to identify nursing problems that can be assisted or resolved with neuromuscular taping, and to identify the characteristics of neuromuscular taping interventions in the field of nursing. Design: A narrative literature review. Methods: A journal search was conducted using the keywords "neuromuscular taping" to collect relevant articles published within the last five years from databases. The inclusion criteria were: randomized controlled trials, quasi-experimental or case reports, participants aged over 17 years, full text articles, studies focusing on nursing problems, and written in English. Twelve journal articles were selected and analyzed using PICO, PEDro scale, ROBINS-I tool, and Pierson score, with a domain/class approach, and list of nursing diagnoses. Results: The results of the literature review indicated that most studies were conducted in Europe with adults and seniors as participants. There were eight randomized controlled trials reports with PEDro scores in a range of 8-9; one quasi-experimental study with ROBINS-I scale in a range of 2; and three case reports with Pierson scores in a range of 9-10 for two articles, and 6-8 for another. All articles provided results which could help with nursing problems. Conclusion: Neuromuscular taping can be applied for acute pain, chronic pain, impaired physical mobility, impaired walking, fatigue, and risk for unstable blood pressure.

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Substance P and Acute Pain in Patients Undergoing Orthopedic Surgery

Cited by 20 publications

References 15 publications

A Mast-Cell-Specific Receptor Mediates Neurogenic Inflammation and Pain

A Mast-Cell-Specific Receptor Mediates Neurogenic Inflammation and Pain

Systemic effects after local injection of platelet-rich plasma: a prospective randomized study

Neuromuscular taping application opportunities in nursing: a literature review

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