Subspace module extraction from MI-based co-expression network

Clerodendrum Glandulosum Lindl.: A Review of Ethnopharmacology, Pharmacological Potentials, and their Mechanism of Action

“…No evidence of toxicity up to 5000 mg/kg bw of extract for acute toxicity and 3000 mg/kg bw for subchronic tests were reported in another study [14] . In subchronic toxicity studies on mice treated with aqueous C. glandulosum extracts at 150 mg/kg, it was reported that the locomotor activity of mice in Actophotometer showed increased motor activity (4.97 %) and muscle grip strength (24.57 %) as compared to the controls [60] . Thus, C. glandulosum leaf extract can be considered safe for therapeutic applications as it is non‐toxic, as evidenced by the reports cited above.…”

“…This confirmed the hypotensive potentials of C. glandulosum , which acts potentially via the inhibition of the Rho/ROCK pathway, which helps in vasoprotection and vasorelaxation [61] . In vivo studies conducted on fructose‐induced hypertensive animal models were reported to indicate parasympathomimetic activity, reduction in blood pressure, and tail pulse in a dose‐dependent manner when administered with C. glandulosum extract and its fractions; a synergistic effect on acetylcholine‐induced contraction of rat ileum smooth muscle was also reported [60] …”

“…It was reported that the ethyl acetate fraction (50 μg/ml) of aqueous C. glandulosum extract showed maximum inhibition of 68.62 % for rho‐associated coiled‐coil protein kinase‐II (ROCK‐II) and 52.28 % for phosphodiesterase‐5 (PDE‐5), in vitro [60] . This confirmed the hypotensive potentials of C. glandulosum , which acts potentially via the inhibition of the Rho/ROCK pathway, which helps in vasoprotection and vasorelaxation [61] .…”