Subsequent Malignancies Associated With Carcinoma of the Uterine Cervix: Including an Analysis of the Effect of Patient and Treatment Parameters on Incidence and Sites of Metachronous Malignancies

Kapp, Daniel S.; Fisher, D.; Grady, Karen J; Schwartz, Peter E.

doi:10.1016/s0022-5347(17)51780-2

Cited by 5 publications

(7 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There is no unanimity in the literature concerning the coexistence of uterine cervix and breast cancers. Some of the authors pointed out the diminished risk of suffering from breast cancer after treatment for cervical cancer, which is explained by different etiological factors, different socio-economic status and loss of ovarian function after cervical cancer treatment [20,21]. However, other series of patients often indicate the coexistence of these cancers.…”

Section: Discussionmentioning

confidence: 99%

“…However, other series of patients often indicate the coexistence of these cancers. The common aetiology in patients of cervical cancer is the reason for the increased risk of suffering from lung, esophagus, bladder and kidney cancers -tobacco related cancers and vulvar and rectal cancer -HPV related [14,[20][21][22]. Stopping smoking by the cancer patient can decrease the risk of suffering from a subsequent cancer of this aetiology.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Multiple Neoplasms Among Cervical Cancer Patients in the Material of the Lower Silesian Cancer Registry

Izmajłowicz¹,

Kornafel²,

Błaszczyk³

2014

Adv Clin Exp Med

View full text Add to dashboard Cite

Background. according to the definition by the International agency for Research on cancer (IaRc), primary multiple neoplasms are two or more neoplasms of different histopathological build in one organ, or two or more tumors occurring in one patient, regardless of the time of their occurrence (synchronic -up to 6 months, metachronous -after 6 months), coming from an organ or a tissue and not being an infiltration from another neoplasm, a relapse or a metastasis. Objectives. It was the aim of the study to analyze the frequency of the occurrence of multiple neoplasms among patients suffering from uterine cervix cancer, with a special interest in coexistent neoplasms, the time of their occurrence and total 5-year survivals. Material and Methods. The data from the Lower Silesian cancer Registry concerning the years 1984-2009 formed the material of the present study. Results. 5.3% of all cervix neoplasms occurred as multiple cancers. cervix neoplasms were 13.4% of multiple neoplasms. On average, cervical cancer occurred as a subsequent cancer in 6 patients yearly (60.7% of the occurrences of cervical cancer were in the period of 5 years following treatment for the first neoplasm). 5-year survival in patients suffering from primarily multiple cervix neoplasms constituted 57% and was convergent with the results for all patients suffering from cervical cancer. cervical cancer as the first neoplasm occurred in 287 patients, on average in 11 patients annually. In the period of the first 5 years after the treatment of cervical cancer, there were 42.8% occurrences of other cancers. cervical neoplasms most frequently coexisted with cancers of the breast, lung and large intestine. Conclusions. The frequency of the occurrence of multiple neoplasm among cervical cancer patients is increasing. Most frequently they coexist with other tobacco-related neoplasms, those related to HPV infections and with secondary post-radiation neoplasms. These facts should be taken into consideration during post-treatment observation and when directing diagnostic and prophylactic tests. Synchronic neoplasms require detailed diagnostics and planning of treatment by a team of specialists. The occurrence of primary multiple cervical neoplasms does not worsen the prognosis as compared to patients suffering exclusively from cervical cancer (Adv Clin Exp Med 2014, 23, 3, 433-440).

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Multiple Neoplasms Among Cervical Cancer Patients in the Material of the Lower Silesian Cancer Registry

Izmajłowicz¹,

Kornafel²,

Błaszczyk³

2014

Adv Clin Exp Med

View full text Add to dashboard Cite

show abstract

“…Therapeutic irradiation can induce secondary malignancies within or at the margin of radiation field after a long latent period (7) . Patients after treatment for gynecological malignancies have a 3-6% lifetime risk of developing a second unrelated malignancy (8,9) . SCC of the genital tissue after radiotherapy is rarely seen and has been widely discussed.…”

Section: Discussionmentioning

confidence: 99%

A case with multiple gynecological malignancies

Göker

Beşe

Ilvan

et al. 2005

Int J Gynecol Cancer

View full text Add to dashboard Cite

A patient with cervical non-Hodgkin lymphoma was treated with chemotherapy. Fourteen months after the diagnosis of the lymphoma, an endometrial adenocarcinoma was detected as a secondary malignant tumor. The patient was treated with surgery followed by radiotherapy. Approximately 7 years after the diagnosis of endometrial cancer, vaginal invasive squamous cell carcinoma was diagnosed as the third primary malignancy, and a second-line palliative radiotherapy was applied. Seven months after the last radiotherapy, postradiational sarcoma in the vagina was diagnosed. Congenital and acquired immune system disorders, viral oncogenes, and various human leukocyte antigen (HLA) types were investigated. Total blood count and lymphocyte subset analysis were performed, and CD4+ lymphopenia was detected. Serologic tests were carried out for human immunodeficiency virus, hepatitis B virus, human papillomavirus, Epstein–Barr virus, and herpes simplex virus infection. Epstein–Barr virus viral capsid antigen IgG was found positive. Low-risk human papillomavirus panel was detected by Hybrid Capture method in the cervical smear. The HLA investigation revealed HLA-A2, HLA-A3, HLA-B57, HLA-B35, HLA-B4, HLA-B6, HLA-DR3, HLA-DR1, HLA-DR51, HLA-DR52, HLA-DQ6(1), and HLA-DQ7(3). The patient died because of the disease.

show abstract

“…The evidence for women undergoing a premature menopause is that they do not have an increase breast cancer risk but should instead continue HRT until the age of the natural menopause [102]. The concern that HRT usage will increase the risk of breast cancer in the treated cervical cancer population is therefore not grounded and some studies have actually indentified a reduced risk in this population [103,104], which is likely to be due to the effect of an early menopause.…”

Section: Second Malignanciesmentioning

confidence: 99%

“…Radiation-associated uterine malignancies are more likely to be of higher grade and stage as compared to spontaneous cancers and as a result carry a poorer prognosis [108]. Several studies have identified an increased association with a second primary lung malignancy [104,109], however this is likely to be a reflection of the smoking behaviour in this population and reinforces the importance of smoking cessation advice and support following a cervical cancer diagnosis.…”

Section: Second Malignanciesmentioning

confidence: 99%