Subsequent malignancies associated with carcinoma of the uterine cervix: Including an analysis of the effect of patient and treatment parameters on incidence and sites of metachronous malignancies

Kapp, Daniel S.; Fischer, Dennis; Grady, Karen J; Schwartz, Peter E.

doi:10.1016/0360-3016(82)90514-4

Cited by 36 publications

(19 citation statements)

References 74 publications

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“…Genetic analyses of normal tissues [16] proved that the lung is very similar to the normal tissues of the female reproduction system, with regard to its gene expression, which could lead to the conclusion that the same genetic modifications might occur in their tumorigenesis. Kapp et al [17] described a significant increase of lung cancer in women with invasive carcinoma of the cervix, treated by radiation therapy. Werner et al [18] also suggest an abnormal genetic background and/or common etiology for the initial and second tumors, because most second neoplasms were distant from the radiation field.…”

Section: Discussionmentioning

confidence: 98%

Primary lung cancer and extrapulmonary malignancy

Hofmann¹,

Neef²,

Schmidt³

2007

European Journal of Cardio-Thoracic Surgery

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Section: Discussionmentioning

confidence: 98%

Primary lung cancer and extrapulmonary malignancy

Hofmann¹,

Neef²,

Schmidt³

2007

European Journal of Cardio-Thoracic Surgery

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“…For this reason, they also suggested that these patients were low responders to EBV (17) . Our patient was HLA-DR 3 positive, whereas negative for HLA-B 8 . There is also one more study reporting an association between HLA-DR 1 and decreased production of antibodies to EBV viral capsid antigen (18) .…”

Section: Discussionmentioning

confidence: 43%

“…Therapeutic irradiation can induce secondary malignancies within or at the margin of radiation field after a long latent period (7) . Patients after treatment for gynecological malignancies have a 3-6% lifetime risk of developing a second unrelated malignancy (8,9) . SCC of the genital tissue after radiotherapy is rarely seen and has been widely discussed.…”

Section: Discussionmentioning

confidence: 99%

A case with multiple gynecological malignancies

Göker

Beşe

Ilvan

et al. 2005

Int J Gynecol Cancer

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A patient with cervical non-Hodgkin lymphoma was treated with chemotherapy. Fourteen months after the diagnosis of the lymphoma, an endometrial adenocarcinoma was detected as a secondary malignant tumor. The patient was treated with surgery followed by radiotherapy. Approximately 7 years after the diagnosis of endometrial cancer, vaginal invasive squamous cell carcinoma was diagnosed as the third primary malignancy, and a second-line palliative radiotherapy was applied. Seven months after the last radiotherapy, postradiational sarcoma in the vagina was diagnosed. Congenital and acquired immune system disorders, viral oncogenes, and various human leukocyte antigen (HLA) types were investigated. Total blood count and lymphocyte subset analysis were performed, and CD4+ lymphopenia was detected. Serologic tests were carried out for human immunodeficiency virus, hepatitis B virus, human papillomavirus, Epstein–Barr virus, and herpes simplex virus infection. Epstein–Barr virus viral capsid antigen IgG was found positive. Low-risk human papillomavirus panel was detected by Hybrid Capture method in the cervical smear. The HLA investigation revealed HLA-A2, HLA-A3, HLA-B57, HLA-B35, HLA-B4, HLA-B6, HLA-DR3, HLA-DR1, HLA-DR51, HLA-DR52, HLA-DQ6(1), and HLA-DQ7(3). The patient died because of the disease.

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“…The place of ionizing radiation in the etiology of second epidermoid genital tumors has been widely discussed (2,19,21,22). Radiotherapy alone or C Acta Obstet Gynecol Scand 79 (2000) combined with surgery is a widely accepted standard treatment in the majority of invasive cervical cancers.…”

Section: Discussionmentioning

confidence: 99%

“…Patients after treatment for gynecologic malignancy have a 3-6% lifetime risk of developing a second unrelated malignancy (2)(3)(4). Although the number of all second cancers in patients after treatment for lower genital tract squamous cell carcinoma is not obviously increased (5)(6)(7), most studies demonstrated an increased risk of developing a new primary within the lower genital tract (2,3,6,(8)(9)(10)(11)(12). The prevalence of these tumors in these patients varies between 2.5 and 37% (8,(12)(13)(14)(15).…”

mentioning

confidence: 99%