Primary lung cancer and extrapulmonary malignancy

Hofmann, Hans‐Stefan; Neef, H; Schmidt, Peter

doi:10.1016/j.ejcts.2007.06.024

Cited by 22 publications

(14 citation statements)

References 24 publications

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“…For example in the studies referenced above, 1 excluded patients with any history of cancer [10], 1 included patients with a history of smoking related cancers [8], 1 excluded patients with a history of cancer within 5 years, 1 excluded patients with a history of renal cancer, melanoma or breast cancer [14], while 2 excluded most cancer patients with exception of non-melanomatous skin cancer, and in-situ carcinoma of the bladder [2], prostate or cervix, [12]. Despite these inconsistencies, the clinical reality is that lung cancer occurring as a second primary malignancy currently accounts for between 8-14% of all lung cancer diagnoses [15], [16], [17], [18], [19]. As lung cancer screening becomes more widely used, the potential inclusion of certain cancer survivors in lung cancer screening programs needs to be more systematically addressed.…”

Section: Discussionmentioning

confidence: 99%

Patients with a Previous History of Malignancy Undergoing Lung Cancer Screening: Clinical Characteristics and Radiologic Findings

Halpenny

Cunningham

Long

et al. 2016

Journal of Thoracic Oncology

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Introduction The aim of this study was to describe the clinical characteristics and radiological findings in patients with a previous history of malignancy who underwent CT screening for lung cancer. Methods Patients with a previous history of malignancy with a life expectancy of at least 5 years referred for lung cancer screening between 5/2/2011 and 9/24/2014 were included. CT features assessed included nodule size, morphology and number. The lung-RADs scoring system was retrospectively applied to all studies. Results 139 patients were studied (mean age 66 years, median pack year smoking history of 50). All had a previous history of cancer, most commonly breast 60 (43%), head/neck 26 (19%) and lung 16 (12%). 42 (30%) patients had a positive screening study. 7 (5%) patients were diagnosed with lung cancer. 1 (1%) patient was diagnosed with a radiation induced chest wall sarcoma. 42 (30%) patients had a positive chest CT as per NCCN Lung Cancer Screening nodule follow-up algorithm. Conclusion The rate of lung cancer diagnosis in our patient population is higher than in several previously published studies. Smokers with a prior history of malignancy may be in a particularly high risk group for the development of subsequent lung cancer.

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Section: Discussionmentioning

confidence: 99%

Patients with a Previous History of Malignancy Undergoing Lung Cancer Screening: Clinical Characteristics and Radiologic Findings

Halpenny

Cunningham

Long

et al. 2016

Journal of Thoracic Oncology

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“…Several authors had reported similar finding like ours, where lung cancer with a secondary malignancy had improved survival compared to those without secondary malignancy. [ 7–10 ] In our cohort, patients with secondary malignancy presents with earlier lung cancer stage and greater proportion of patient receiving surgical treatment. In the study by Hofmann et al, [7] the improved survival by patient with additional secondary malignancy is determined by a shift towards lower tumor stages and fewer SCLCs.…”

Section: Discussionmentioning

confidence: 99%

“…[ 7–10 ] In our cohort, patients with secondary malignancy presents with earlier lung cancer stage and greater proportion of patient receiving surgical treatment. In the study by Hofmann et al, [7] the improved survival by patient with additional secondary malignancy is determined by a shift towards lower tumor stages and fewer SCLCs. However, others had reported better survival for patients without a second malignancy or no difference.…”

Section: Discussionmentioning

confidence: 99%

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Clinical outcome in lung cancer with a second malignancy

Chen²,

Huang³

et al. 2016

Medicine

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The aim of the study was to determine the clinical outcome of lung cancer patients with a secondary malignancy according to the time sequence between the lung cancer and the secondary malignancy.Retrospective review of all lung cancer patients with any secondary cancer treated from June 2004 to July 2012. The survival of patients with a secondary malignancy was compared to those patients without a secondary malignancy. According to the time sequence between the lung cancer and the secondary malignancy, patients were divided into 4 groups. Group I: lung cancer without any other malignancy, Group II: lung cancer with a secondary malignancy at follow-up, Group III: lung cancer with a pre-existing malignancy, Group IV: synchronous malignancies (diagnosis interval between lung cancer and a secondary malignancy of less than 3 months).Patients with any secondary cancer in their history or at follow up included 157 patients (9.5%). Collectively; the median survival was significantly better for patients with a secondary malignancy, 19.09 months, compared to those without a secondary malignancy, 9.53 months, P < 0.001, HR 0.66 (95% CI 0.55 – 0.79). However, the survival differed significantly according to the time sequence between the lung cancer and the secondary malignancy. The median survival was 47.9 months for group II patients, 12.19 months for group III, 17.51 months for group IV, and 9.53 months for group I; P = 0.001. In Cox proportional hazard analysis, the risk of dying decreased by 68% in group II patients compared to group I patients, HR 0.32 (95% CI 0.21–0.5), P < 0.001. Although the risk of dying for group III and IV decreased by 19% and 16% respectively compared to group I patients, it did not reach statistical significance.Nowadays, secondary malignancy in lung cancer patients is a frequent finding. Better survival was observed for patient with secondary malignancy following lung cancer.

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“…Most second primary lung cancers occur synchronously within 24 months to index head and neck cancer [7]. Oro-hypopharynx or larynx are the most common sites of index head and neck tumor and ‘squamous cell’ is the most common histological type of index head and neck tumor associated with second primary lung cancer development [8].…”

Section: Discussionmentioning

confidence: 99%

Second Primary Lung Cancer with Glottic Laryngeal Cancer as Index Tumor – A Case Report

et al. 2010

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Patients with laryngeal cancer have a high risk of developing lung cancer in the future. A patient presented with a complaint of left-sided chest pain for the last 3 months. Chest X-ray posterior-anterior view showed a homogeneous opacity in the left upper lung field with elevation of the diaphragm on the left side. CECT thorax revealed a heterogeneously enhancing soft tissue density mass lesion in the superior segment of the lingular lobe. On histopathological examination of the mass lesion, it was diagnosed as adenocarcinoma of the lung. About 10 months previously, the patient was treated for a laryngeal squamous cell carcinoma. Patients with laryngeal cancer should be routinely screened during follow-up with chest X-ray or CT scan for the early detection of lung cancer.

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Primary lung cancer and extrapulmonary malignancy

Abstract: In cases of operability, standard resection must be the method of choice, because of its best survival rates. The results support the demand of an exact and short-term oncological care system to detect early stages of SPLC for patients operated upon for tumors at different sites.

Cited by 22 publications

References 24 publications

Patients with a Previous History of Malignancy Undergoing Lung Cancer Screening: Clinical Characteristics and Radiologic Findings

Patients with a Previous History of Malignancy Undergoing Lung Cancer Screening: Clinical Characteristics and Radiologic Findings

Clinical outcome in lung cancer with a second malignancy

Second Primary Lung Cancer with Glottic Laryngeal Cancer as Index Tumor – A Case Report

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