Subregional volumes of the hippocampus in relation to cognitive function and risk of dementia

Evans, Tavia E.; Adams, Hieab H.H.; Licher, Silvan; Wolters, Frank J.; Lugt, Aad van der; Ikram, Mohammad Kamran; O’Sullivan, Michael; Vernooij, Meike W.

doi:10.1016/j.neuroimage.2018.05.041

Cited by 79 publications

(48 citation statements)

References 49 publications

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“…Our results in T2DM-CI patients revealed that the volume changes of the left presubiculum were correlated with the MMSE scores and the atrophy of the left subiculum, the left presubiculum and the left fimbria were related to executive function, while the atrophy of the right CA1 was related to memory. This coincided with the study of Evans et al, who found that the decreased volume of the hippocampal subiculum, presubiculum and fimbria was strongly associated with poor performance on executive function, not memory [45]. However, no similar result has been found in T2DM patients according to our knowledge, further study is needed.…”

Section: Discussionsupporting

confidence: 90%

“…A structural imaging study in patients with subjective cognitive decline found volume reductions in the presubiculum, molecular layer and fimbria [19]. Another study in a large population-based cohort reported smaller volumes of the hippocampal fimbria, presubiculum and subiculum that was related to a risk of dementia [45]. Both basic research and clinical research has confirmed the roles of these hippocampal subfields in learning and memory.…”

Section: Discussionmentioning

confidence: 99%

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Atrophy patterns of hippocampal subfields in T2DM patients with cognitive impairment

Huang

Yang

et al. 2020

Endocrine

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Purpose To identify the volume changes of hippocampus subfields in T2DM patients with cognitive impairment and to determine how these atrophy patterns associate with impairments in different cognitive domain. Methods A total of 117 individuals were recruited, including T2DM patients with cognitive impairment (T2DM-CI) (n = 34), T2DM patients without cognitive impairment (T2DM-non-CI) (n = 36) and normal controls (NC) (n = 47). All subjects went through a 3.0 T magnetic resonance (MR) scan and a neuropsychological assessment. Hippocampal subfield volumes were processed using the FreeSurfer 6.0.0 and compared among the three groups. Partial correlation analyses were used to estimate the relationship between cognitive function and hippocampal subfield volume, with age, sex, education, and eTIV (estimated total intracranial volume) as covariants. Results The total hippocampal volume had a reduction trend among the three groups, and the significantly statistical difference only was found between T2DM-CI group and NC group. Regarding the hippocampal subfields, the volumes of left subiculum, left presubiculum, left fimbria, right CA1 and right molecular layer HP decreased significantly in the T2DM-CI group (P < 0.05/12). Partial correlation analyses showed that the volumes of the left subiculum, left fimbria, and left presubiculum were significantly related to executive function. The right hippocampal CA1 volume was significantly correlated with memory in the T2DM-CI group (P < 0.05). But in T2DM-non-CI group, the correlation between the left fimbria volume and the memory, the left subiculum volume and MoCA were different with the T2DM-CI group and NC group (P < 0.05). Conclusions The smaller the volume of left presubiculum, the worse the executive function, and the atrophy of the right CA1 was related to memory impairment in T2DM-CI group. However the result was the opposite in T2DM-non-CI group. There might be a compensation mechanism of hippocampus of T2DM patients before cognitive impairment.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Atrophy patterns of hippocampal subfields in T2DM patients with cognitive impairment

Huang

Yang

et al. 2020

Endocrine

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“…), bringing together a number of the disparate previous ndings by showing (crosssectional) age effects across the hippocampus and its sub elds that is above age-dependent global grey matter atrophy. Some of the highest annualised volume losses were observed in the presubiculum and subiculum, in line with ndings which report presubiculum atrophy being associated with cognitive decline and low subiculum volume associated with long-term dementia risk (Evans et al 2018). Presubiculum and subiculum volume across ageing and APOE e status may therefore be useful markers of future cognitive decline and may explain the relationships observed with both ageing and AD risk across studies.…”

Section: Interactions Between Age and Apoe E Status On Selective Hippsupporting

confidence: 85%

The human hippocampus and its subfield volume across age, sex and APOE e4 status

Veldsman

Nobis

Almagro

et al. 2020

Preprint

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Female sex, age and carriage of the APOE e4 allele are the greatest risk factors for sporadic Alzheimer's disease (AD). The hippocampus has a selective vulnerability to atrophy in ageing that may be accelerated in AD, including in those with increased genetic risk of AD. Within the hippocampal complex, subfields represent cytoarchitectonic and connectivity based divisions. The change in global hippocampal and subfield volume associated with sex, age and APOE e4 status in healthy ageing have not yet been established despite their potential to provide a sensitive biomarker of future vulnerability to AD. Here, we examined non-linear age, sex and APOE effects, and their interactions, on hippocampal and subfield volumes across several decades spanning mid-life to old age in 36 653 healthy ageing individuals. Hippocampal volume showed a marked reduction in APOE e4/e4 female carriers after age 65. Volume was lower in homozygous e4 individuals in specific subfields including the presubiculum, subiculum head, CA1 body, CA3 head and CA4. The findings demonstrate that in healthy ageing, two factors - female sex and APOE e4 status - confer selective vulnerability of specific hippocampal subfields to volume loss.

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“…Furthermore, consistency has been found in connectivity profiles across field strength 55 . Additionally, 1.5T scanning is still widely used in both clinical and large prospective cohort studies 40,[56][57][58] .…”

Section: Discussionmentioning

confidence: 99%

Hierarchical Complexity of the Adult Human Structural Connectome

Smith

Bastin

Cox

et al. 2018

Preprint

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Subregional volumes of the hippocampus in relation to cognitive function and risk of dementia

Abstract: In a community-dwelling non-demented population, we describe patterns of association between hippocampal subregions with cognition and risk of dementia. Specifically, the subiculum was associated with both poorer cognition and higher risk of dementia.

Cited by 79 publications

References 49 publications

Atrophy patterns of hippocampal subfields in T2DM patients with cognitive impairment

Atrophy patterns of hippocampal subfields in T2DM patients with cognitive impairment

The human hippocampus and its subfield volume across age, sex and APOE e4 status

Hierarchical Complexity of the Adult Human Structural Connectome

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