Sublingual immunotherapy for hazelnut food allergy: A randomized, double-blind, placebo-controlled study with a standardized hazelnut extract

Enrique, Ernesto; Pineda, Fernando; Malek, Tamim; Bartra, Joan; Basagaña, María; Tella, R.; Castelló, José Vicente; Alonso, Ricardo; Mateo, José Antonio de; Cerdá-Trias, T.; Miguel-Moncín, María del Mar San; Monzón, Susana; García, María del Carmen García; Palácios, Ricardo; Cisteró-Bahíma, A

doi:10.1016/j.jaci.2005.08.027

Cited by 374 publications

(275 citation statements)

References 39 publications

(48 reference statements)

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“…[27][28][29][30][31][32] Atopic respiratory conditions have also been linked to similar changes in IL-6, IL-10, and 5-lipoxygenase. [33][34][35][36] Given these relationships, inflammation may be a critical link between atopic respiratory conditions and stroke.…”

Section: Discussionmentioning

confidence: 99%

The Association Between Allergy Skin Testing, Atopic Respiratory Conditions, and Stroke Mortality in Middle-Aged and Elderly Adults

Matheson¹,

Mainous²,

Carnemolla³

2009

The Journal of the American Board of Family Medicine

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Background: A history of atopic respiratory conditions has been linked to an increased risk of stroke. What remains unclear is whether positive allergy skin testing is associated with an increased risk of stroke. The primary goal of this study was to determine whether positive allergy skin testing is associated with an increased risk of fatal stroke. A secondary goal is to determine whether having both positive allergy skin testing and an atopic respiratory condition is associated with a particularly high risk of stroke death.Methods: An analysis was performed of the National Health and Nutrition Examination Survey II Mortality Cohort.Results: Controlling for age, gender, race, alcohol use, smoking status, diabetes, hypertension, and body mass index, patients with positive allergy skin testing had a hazard ratio for stroke mortality of 1.56 (95% CI, 1.01-2.40) versus those without positive allergy testing. Patients with both positive allergy testing and an atopic respiratory condition had a hazard ratio for stroke mortality of 2.31 (95% CI, 1.13-4.73).Conclusions: Individuals with both positive allergy skin testing and an atopic respiratory condition have more than a 2-fold increased risk of fatal stroke. This novel risk factor has substantial implications for a large segment of the population not previously considered at risk.

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Section: Discussionmentioning

confidence: 99%

The Association Between Allergy Skin Testing, Atopic Respiratory Conditions, and Stroke Mortality in Middle-Aged and Elderly Adults

Matheson¹,

Mainous²,

Carnemolla³

2009

The Journal of the American Board of Family Medicine

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“…SLIT has been used effectively in subjects allergic to kiwi, hazelnut, peach, milk, and peanut [51•, 66-69, 70•]. & In a study by Enrique et al [68], hazelnut-allergic subjects received SLIT for 8-12 weeks. Following treatment, SLIT-treated subjects had increases in hazelnut-specific IgG-4 as well as IL-10 compared with controls.…”

Section: Sublingual Immunotherapymentioning

confidence: 99%

Immunomodulatory Effect of Active Treatment Options in Food Allergy

Pesek

Jones

2014

Curr Treat Options Allergy

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“…La vía que ha demostrado eficacia y seguridad ha sido la vía sublingual para el tratamiento de rinitis y conjuntivitis 17,18 . Asimismo, la inmunoterapia sublingual frente a alimentos está en fase importante de desarrollo obteniéndo-se resultados prometedores 19,20 . Otra vía interesante por su gran aceptación por parte de los pacientes es la vía oral.…”

Section: Nuevas Formas Farmacéuticasunclassified

Nuevas formas farmacéuticas para el tratamiento de enfermedades alérgicas

Ferrer

Sánz

Gastaminza

et al. 2012

Anales Sis San Navarra

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resuMenLa inmunoterapia para el tratamiento de enfermedades alérgicas implica ciertas desventajas, que pueden ser reducidas si se emplean adyuvantes adecuados, que sean capaces de amplificar la respuesta inmune con un efecto alergénico mínimo. En ese contexto, las formas farmacéuticas más prometedoras para aumentar la eficacia y seguridad de la inmunoterapia, parecen ser las micro y nanopartículas, de polímeros biodegradables y liposomas. En esta revisión describimos estudios previos de nuestro grupo en los que empleamos como adyuvante nanopartículas Gantrez® AN y demostramos su capacidad de estimular el sistema inmune. Empleamos dos tipos de nanopartículas, con y sin lipopolisacárido de Brucella ovis como inmunomodulador en un modelo de ratón alérgico a L. perenne. Encontramos que los ratones sensiblizados a Phleum cuando recibían inmunoterapia con nanopartículas Lolium-Gantrez® estaban protegidos de la anafilaxia inducida por el alérgeno tanto en las tasas de mortalidad como en los niveles de MCP-1. Probamos asimismo estas formulaciones por vía oral en un modelo animal sensibilizado a ovoalbúmina y comprobamos que les protegía también del shock anafiláctico.Palabras clave. Inmunoterapia. Alergia. Nanopartícu-las. Micropartículas. AbstrActSpecific immunotherapy involves certain drawbacks which could be minimized by the use of appropriate adjuvants, capable of amplifying the right immune response with minimal side effects. In this context, we review different types of immunotherapy vehicles and coadyuvants. We describe previous studies by our group in which we demonstrated the adjuvant capacity of Gantrez® AN nanoparticles, which can effectively enhance the immune response. We employed two types of nanoparticles (with and without LPS of Brucella ovis as immunomodulator) within capsulated ovoalbumin and Lollium perenne extract, tested on a model of mice sensitized to this allergenic mixture. In the challenge experiment involving the sensitized mice, differences in the mortality rate and in the MCP-1 levels were found between the treated groups and the control. Under the experimental conditions of this model of mice pre-sensitized to L. perenne, Gantrez®AN nanoparticles appeared to be a good strategy for immunotherapy. We finally tested these carriers administered by the oral route and found that they were able to protect a model of mice sensitized to ovalbumin from anaphylactic shock.

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Sublingual immunotherapy for hazelnut food allergy: A randomized, double-blind, placebo-controlled study with a standardized hazelnut extract

Cited by 374 publications

References 39 publications

The Association Between Allergy Skin Testing, Atopic Respiratory Conditions, and Stroke Mortality in Middle-Aged and Elderly Adults

The Association Between Allergy Skin Testing, Atopic Respiratory Conditions, and Stroke Mortality in Middle-Aged and Elderly Adults

Immunomodulatory Effect of Active Treatment Options in Food Allergy

Nuevas formas farmacéuticas para el tratamiento de enfermedades alérgicas

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