Immunomodulatory Effect of Active Treatment Options in Food Allergy

Pesek, Robbie D.; Jones, Stacie M.

doi:10.1007/s40521-014-0016-y

Cited by 1 publication

(2 citation statements)

References 85 publications

(60 reference statements)

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Section: Introductionmentioning

confidence: 99%

“…Food allergy is an adverse reaction mediated by the immune system (Pesek & Jones, 2014). Food allergies are often accompanied by a series of symptoms that can affect the gastrointestinal tract, skin and respiratory systems, as well as systemic reaction which could be fatal (Pesek & Jones, 2014). In animal husbandry, the feed protein antigen commonly causes allergic reactions in young animals, seriously hindering their growth and development, greatly reducing their survival, and even causing a narrow escape from death in small animals.…”

Section: Introductionmentioning

confidence: 99%

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Immunomodulatory effects of Glycyrrhiza uralensis polysaccharide in glycinin-induced allergic mouse model

Chen

et al. 2016

Food and Agricultural Immunology

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This study aimed to investigate the therapeutic effects of Glycyrrhiza uralensis polysaccharide (GUP) on glycinin-induced allergic reactions in mouse model. Female BALB/c mice were pretreated for seven consecutive days with various concentrations of GUP aqueous solution or blank control. The mice were then orally administered with glycinin (10 mg/ml) three times and observed a week later. The survival rate and other indicators of the mice were measured, while IL-4, IL-13, plasma histamine and the lgE and IgG content in the serum were detected by enzyme-linked immunosorbent assay. The percentage of CD4+CD25+FoxP3+T cells was detected by flow cytometry. The results showed that IL-4, IL-13 and plasma histamine levels significantly decreased in the blood of mice treated with low GUP concentrations (20 mg/ml), while the specific glycinin-IgE, glycinin-IgG inhibition ratio and CD4+CD25 +FoxP3+ T cells/CD4+ T cells ratio increased. However, the lowest, middle, high and the highest concentrations of GUP did not have significant effects on the immune reactions of glycinin-induced allergic mice. In conclusion, our study suggests that GUP is a promising agent to inhibit glycinin-induced allergy.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%