Abstract:Thioredoxin reductase (TrxR) reduces thioredoxin (Trx), thereby contributing to cellular redox balance, facilitating the synthesis of deoxy-ribose sugars for DNA synthesis, and regulating redox-sensitive gene expression. Auranofin is a gold compound that potently inhibits TrxR. This inhibition is one suspected mechanism of auranofin's therapeutic benefit in the treatment of rheumatoid arthritis. The use of other gold compounds to treat cancer or inflammatory disease may rely on their ability to inhibit TrxR. I… Show more
“…The low cytotoxicity of aurothiosulfate is consistent with the results of a prior study in which the MTT assay was used to measure its effects on human THP1 monocytes; no cytotoxicity was observed with 5 µM aurothiosulfate [46].…”
“…The low cytotoxicity of aurothiosulfate is consistent with the results of a prior study in which the MTT assay was used to measure its effects on human THP1 monocytes; no cytotoxicity was observed with 5 µM aurothiosulfate [46].…”
“…39 The upregulation of the transcript for a gene similar to that encoding AIRAP is not surprising since both arsenite and auranofin are inhibitors of thioredoxin reductase. [40][41][42][43] Auranofin had half-maximal inhibitory concentration (IC 50 ) of 0.4 μM against active, recombinant E. histolytica thioredoxin reductase (EhTrxR). Since E. histolytica does not have a glutathione reductase system, EhTrxR is critical for protecting amebic trophozoites from oxidant attack.…”
Section: Future Of Auranofin For Amebiasis Giardiasis and Cryptospormentioning
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