Subjective evaluation of smell and taste dysfunction in patients with mild COVID-19 in Spain

Ninchritz-Becerra, Elisabeth; Soriano-Reixach, María Montserrat; Mayo‐Yáñez, Miguel; Calvo‐Henríquez, Christian; Apodaca, Paula Martínez Ruiz de; Saga-Gutierrez, Carlos; Parente‐Arias, Pablo; Villareal, Ithzel María; Viera‐Artiles, Jaime; Poletti-Serafini, Daniel; Alobid, Isam; Ayad, Tareck; Saussez, Sven; Lechien, Jérôme R.; Chiesa‐Estomba, Carlos Miguel

doi:10.1016/j.medcle.2020.08.004

Cited by 15 publications

(17 citation statements)

References 7 publications

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“…This finding suggests that disease severity may not have significant effects on olfactory loss; however, this is contrary to other larger studies which have highlighted mild as opposed to more severe Covid-19 disease as a significant predictor of olfactory dysfunction. 2 , 10 …”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Of note, individuals with mild Covid-19 tend to have higher rates of olfactory dysfunction than those with severe disease. 2 , 10 …”

Section: Introductionmentioning

confidence: 99%

“…The loss of sense of smell (anosmia or hyposmia) has emerged as an unexpected though significant and revealing early sign of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, occurring as the first sign of infection in up to 17 per cent of patients. 1,2 The SARS-CoV-2 infection can occur asymptomatically or with various degrees of coronavirus disease 2019 (Covid-19) severity. [3][4][5] Olfactory dysfunction has been shown to occur in patients acutely infected with SARS-CoV-2 at rates of 25-98 per cent.…”

Section: Introductionmentioning

confidence: 99%

“…[3][4][5] Olfactory dysfunction has been shown to occur in patients acutely infected with SARS-CoV-2 at rates of 25-98 per cent. 1,2,[6][7][8][9] This large variability in reported rates of olfactory dysfunction is likely multifactorial, with sizeable differences in sample size between studies, and with some using subjective reports of smell loss and others using objective testing methods. Of note, individuals with mild Covid-19 tend to have higher rates of olfactory dysfunction than those with severe disease.…”

Section: Introductionmentioning

confidence: 99%

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Olfactory dysfunction at six months after coronavirus disease 2019 infection

et al. 2021

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Objective This study aimed to assess olfactory dysfunction in patients at six months after confirmed coronavirus disease 2019 infection. Methods Coronavirus disease 2019 positive patients were assessed six months following diagnosis. Patient data were recoded as part of the adapted International Severe Acute Respiratory and Emerging Infection Consortium Protocol. Olfactory dysfunction was assessed using the University of Pennsylvania Smell Identification Test. Results Fifty-six patients were included. At six months after coronavirus disease 2019 diagnosis, 64.3 per cent of patients (n = 36) were normosmic, 28.6 per cent (n = 16) had mild to moderate microsmia and 7 per cent (n = 4) had severe microsmia or anosmia. There was a statistically significant association between older age and olfactory dysfunction. Hospital or intensive care unit admission did not lead to worse olfactory outcomes compared to those managed in the out-patient setting. Conclusion At six months after coronavirus disease 2019 diagnosis, approximately two-thirds of patients will be normosmic. This study is the first to describe six-month outcomes for post-coronavirus disease 2019 patients in terms of olfactory dysfunction.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Of note, individuals with mild Covid-19 tend to have higher rates of olfactory dysfunction than those with severe disease. 2 , 10 …”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Olfactory dysfunction at six months after coronavirus disease 2019 infection

et al. 2021

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Olfactory dysfunction in COVID‐19, new insights from a cohort of 353 patients: The ANOSVID study

Mercier¹,

Osman

Bouiller

et al. 2022

Journal of Medical Virology

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Olfactory disorders (OD) pathogenesis, underlying conditions, and prognostic in coronavirus disease 2019 (COVID‐19) remain partially described. ANOSVID is a retrospective study in Nord Franche‐Comté Hospital (France) that included COVID‐19 patients from March 1 2020 to May 31 2020. The aim was to compare COVID‐19 patients with OD (OD group) and patients without OD (no‐OD group). A second analysis compared patients with anosmia (high OD group) and patients with hyposmia or no OD (low or no‐OD group). The OD group presented less cardiovascular and other respiratory diseases compared to the no‐OD group (odds ratio [OR] = 0.536 [0.293–0.981], p = 0.041 and OR = 0.222 [0.056–0.874], p = 0.037 respectively). Moreover, history of malignancy was less present in the high OD group compared with the low or no‐OD group (OR = 0.170 [0.064–0.455], p < 0.001). The main associated symptoms (OR > 5) with OD were loss of taste (OR = 24.059 [13.474–42.959], p = 0.000) and cacosmia (OR = 5.821 [2.246–15.085], p < 0.001). Most of all ORs decreased in the second analysis, especially for general, digestive, and ENT symptoms. Only two ORs increased: headache (OR = 2.697 [1.746–4.167], p < 0.001) and facial pain (OR = 2.901 [1.441–5.842], p = 0.002). The high OD group had a higher creatinine clearance CKD than the low or no‐OD group (89.0 ± 21.1 vs. 81.0 ± 20.5, p = 0.040). No significant difference was found concerning the virological, radiological, and severity criteria. OD patients seem to have less comorbidity, especially better cardiovascular and renal function. Associated symptoms with OD were mostly neurological symptoms. We did not find a significant relationship between OD and less severity in COVID‐19 possibly due to methodological bias.

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Food‐related experiences and behavioral responses among people affected by chemosensory dysfunctions following COVID‐19: A scoping review

Neuman,

Sandvik,

Lindholm

et al. 2023

Research in Nursing & Health

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A category of symptoms that became characteristic early in the first wave of the coronavirus disease 2019 (COVID‐19) pandemic was chemosensory dysfunctions (alterations of smell and taste). Such symptoms substantially affect food and eating—cornerstones for both nutrition‐related health outcomes and for quality of life. Based on this, this scoping review aimed to map out existing scientific literature on food‐related experiences and related behavioral responses among people affected by chemosensory dysfunctions following COVID‐19. A librarian‐supported search of PsycInfo, PubMed, and Scopus for publications written in English (2020 to April 26, 2022) was conducted. Two authors searched for and screened publications and three others extracted and collated data. These are reported following the Preferred Reporting Items of Systematic reviews and Meta‐Analyses extension for Scoping Reviews. Of 1169 hits, 9 publications were included in the review. The results are thematized as “Psychological and social aspects” and “Nutritional aspects,” each with the subsections “Experiences” and “Behavioral responses.” A great variety of food‐related problems, nutritional and mental health effects, and implications for social life are identified. People affected by chemosensory dysfunctions following COVID‐19 suffer, as evident both in stories from qualitative studies and in measurements of quality of life. The results impact all professions who are and may come to be involved in treating these patients, such as nurses, physicians, dietitians, and psychologists. With more knowledge about the dysfunctions' manifestation, duration, and impact on everyday life, multiprofessional teams need to collaborate in supporting patients medically, psychosocially, and nutritionally.

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Subjective evaluation of smell and taste dysfunction in patients with mild COVID-19 in Spain

Cited by 15 publications

References 7 publications

Olfactory dysfunction at six months after coronavirus disease 2019 infection

Olfactory dysfunction at six months after coronavirus disease 2019 infection

Olfactory dysfunction in COVID‐19, new insights from a cohort of 353 patients: The ANOSVID study

Food‐related experiences and behavioral responses among people affected by chemosensory dysfunctions following COVID‐19: A scoping review

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