Subjective evaluation of experimental dyspnoea – Effects of isocapnia and repeated exposure

Hayen, Anja; Herigstad, Mari; Wiech, Katja; Pattinson, Kyle T.S.

doi:10.1016/j.resp.2014.12.019

Cited by 15 publications

(13 citation statements)

References 30 publications

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“…A breathing system was used to remotely administer periods of inspiratory resistive loading to induce breathlessness as predicted by the conditioned cues ( Hayen et al, 2013a , 2015 ), identical to that previously described ( Faull et al, 2016b ). End-tidal oxygen and carbon dioxide were maintained constant ( Faull et al, 2016b ).…”

Section: Methodsmentioning

confidence: 99%

The cortical connectivity of the periaqueductal gray and the conditioned response to the threat of breathlessness

Faull

Pattinson

2017

eLife

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Previously we observed differential activation in individual columns of the periaqueductal grey (PAG) during breathlessness and its conditioned anticipation (Faull et al., 2016b). Here, we have extended this work by determining how the individual columns of the PAG interact with higher cortical centres, both at rest and in the context of breathlessness threat. Activation was observed in ventrolateral PAG (vlPAG) and lateral PAG (lPAG), where activity scaled with breathlessness intensity ratings, revealing a potential interface between sensation and cognition during breathlessness. At rest the lPAG was functionally correlated with cortical sensorimotor areas, conducive to facilitating fight/flight responses, and demonstrated increased synchronicity with the amygdala during breathlessness. The vlPAG showed fronto-limbic correlations at rest, whereas during breathlessness anticipation, reduced functional synchronicity was seen to both lPAG and motor structures, conducive to freezing behaviours. These results move us towards understanding how the PAG might be intricately involved in human responses to threat.DOI: http://dx.doi.org/10.7554/eLife.21749.001

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Section: Methodsmentioning

confidence: 99%

The cortical connectivity of the periaqueductal gray and the conditioned response to the threat of breathlessness

Faull

Pattinson

2017

eLife

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“…Furthermore repeated exposure to dyspnea can result in either increasing (sensitization) or decreasing (habituation) dyspnea perception ( Bloch-Salisbury et al, 1996 ; Carrieri-Kohlman et al, 2001 ; Wan et al, 2008 , 2009 ; von Leupoldt et al, 2011a ; Hayen et al, 2015 ). Habituation toward dyspnea seems favorable in conditions such as COPD and panic disorder.…”

Section: Introductionmentioning

confidence: 99%

Brain mechanisms of short-term habituation and sensitization toward dyspnea

et al. 2015

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Dyspnea is a prevalent and threatening cardinal symptom in many diseases including asthma. Whether patients suffering from dyspnea show habituation or sensitization toward repeated experiences of dyspnea is relevant for both quality of life and treatment success. Understanding the mechanisms, including the underlying brain activation patterns, that determine the dynamics of dyspnea perception seems crucial for the improvement of treatment and rehabilitation. Toward this aim, we investigated the interplay between short-term changes of dyspnea perception and changes of related brain activation. Healthy individuals underwent repeated blocks of resistive load induced dyspnea with parallel acquisition of functional magnetic resonance imaging data. Late vs. early ratings on dyspnea intensity and unpleasantness were correlated with late vs. early brain activation for both, dyspnea anticipation and dyspnea perception. Individual trait and state anxiety were determined using questionnaire data. Our results indicate an involvement of the orbitofrontal cortex (OFC), midbrain/periaqueductal gray (PAG) and anterior insular cortex in habituation/sensitization toward dyspnea. Changes in the anterior insular cortex were particularly linked to changes in dyspnea unpleasantness. Changes of both dyspnea intensity and unpleasantness were positively correlated with state and trait anxiety. Our findings are in line with the suggested relationship between the anterior insular cortex and dyspnea unpleasantness. They further support the notion that habituation/sensitization toward dyspnea is influenced by anxiety. Our study extends the known role of the midbrain/PAG in anti-nociception to an additional involvement in habituation/sensitization toward dyspnea and suggests an interplay with the OFC.

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“…First, experimentally induced dyspnoea may alter the FMRI signal (e.g. with hypercapnia and/or resistive respiratory loading ( Hayen et al, 2012 , Hayen et al, 2015 )), particularly at higher field strengths ( Faull et al, 2015 ). Second, induced dyspnoea may be difficult to tolerate, especially for a supine COPD patient in a claustrophobic MRI environment.…”

Section: Discussionmentioning

confidence: 99%

Development of a dyspnoea word cue set for studies of emotional processing in COPD

Herigstad

Hayen

Reinecke

et al. 2016

Respiratory Physiology & Neurobiology

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Subjective evaluation of experimental dyspnoea – Effects of isocapnia and repeated exposure

Cited by 15 publications

References 30 publications

The cortical connectivity of the periaqueductal gray and the conditioned response to the threat of breathlessness

The cortical connectivity of the periaqueductal gray and the conditioned response to the threat of breathlessness

Brain mechanisms of short-term habituation and sensitization toward dyspnea

Development of a dyspnoea word cue set for studies of emotional processing in COPD

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