Development of a dyspnoea word cue set for studies of emotional processing in COPD

Herigstad, Mari; Hayen, Anja; Reinecke, Andrea; Pattinson, Kyle T. S.

doi:10.1016/j.resp.2015.12.006

Cited by 26 publications

(34 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Detailed methods are provided at the end of this manuscript. Comparison of pre-rehabilitation FMRI findings with healthy controls and a detailed description of the breathlessnesscue task have been published elsewhere (13,14).…”

Section: Methodsmentioning

confidence: 99%

“…A structural T1-weighted scan (voxel size 1x1x1 mm), functional (FMRI) T2*-weighted scan (voxel size 3x3x3 mm) and fieldmaps were collected. During the FMRI scans, participants were shown a randomised set of breathlessness-related word cues (13) and asked to rate each cue according to breathlessness and breathlessnessanxiety on a visual analogue scale (VAS), with the question "How breathless would this make you feel?" (wB) and the "How anxious would this make you feel?"…”

Section: Brain Imaging and Analysismentioning

confidence: 99%

“…Some of the findings have already been published (14) in a study that compared baseline (pre-rehabilitation) FMRI findings with a healthy control group. A more detailed description of the development and validation of the word-cue task has also been published (41).…”

Section: Participantsmentioning

confidence: 99%

“…We therefore assessed conditioned breathlessness and associated brain activity in a group of patients with COPD before and after a course of pulmonary rehabilitation. With functional magnetic resonance imaging (FMRI) we measured the brain's response to a validated set of breathlessness-related word cues (13) in combination with detailed clinical and psychological characterisation.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Treating the lungs via the brain: Mechanisms underpinning improvements in breathlessness with pulmonary rehabilitation

Herigstad

Faull

Hayen

et al. 2017

Preprint

Self Cite

View full text Add to dashboard Cite

BackgroundBreathlessness in chronic obstructive pulmonary disease (COPD) is often discordant with airway pathophysiology (“over-perception”). Pulmonary rehabilitation has profound effects upon breathlessness, without influencing lung function. Learned associations can influence brain mechanisms of sensory perception. We therefore hypothesised that improvements in breathlessness with pulmonary rehabilitation may be explained by changing neural representations of learned associations, reducing “over-perception”.MethodsIn 31 patients with COPD, we tested how pulmonary rehabilitation altered the relationship between brain activity during learned associations with a word-cue task (using functional magnetic resonance imaging), clinical, and psychological measures of breathlessness.ResultsImprovements in breathlessness and breathlessness-anxiety correlated with reductions in word-cue related activity in the insula and anterior cingulate cortex (ACC) (breathlessness), and increased activations in attention regulation and motor networks (breathlessness-anxiety). Greater baseline (pre-rehabilitation) activity in the insula, ACC and prefrontal cortex correlated with the magnitude of improvement in breathlessness and breathlessness anxiety.ConclusionsPulmonary rehabilitation reduces the influence of learned associations upon neural processes that generate breathlessness. Patients with stronger word-cue related activity at baseline benefitted more from pulmonary rehabilitation. These findings highlight the importance of targeting learned associations within treatments for COPD, demonstrating how neuroimaging may contribute to patient stratification and more successful personalised therapy.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Brain Imaging and Analysismentioning

confidence: 99%

Section: Participantsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Treating the lungs via the brain: Mechanisms underpinning improvements in breathlessness with pulmonary rehabilitation

Herigstad

Faull

Hayen

et al. 2017

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…Abnormal respiratory signalling is shaped by a variety of emotional and psychological processes in different parts of the brain, the interactions of which lead to the sensations of breathlessness. Drawing a parallel from COPD, there is mounting evidence that many of the beneficial effects of pulmonary rehabilitation derive from relieving anxiety about breathlessness rather than the physical sensations of breathlessness [19,20]. Thus in the context of ALS a potential beneficial strategy may be to consider anxiety about breathlessness independently, especially once medical therapy is optimised [21].…”

mentioning

confidence: 99%

A wider pathological network underlying breathlessness and respiratory failure in amyotrophic lateral sclerosis

Pattinson

Turner

2016

Eur Respir J

Self Cite

View full text Add to dashboard Cite

Breathlessness and the body: Neuroimaging clues for the inferential leap

Faull

Hayen

Pattinson

2017

Cortex

Self Cite

View full text Add to dashboard Cite

Breathlessness debilitates millions of people with chronic illness. Mismatch between breathlessness severity and objective disease markers is common and poorly understood. Traditionally, sensory perception was conceptualised as a stimulus-response relationship, although this cannot explain how conditioned symptoms may occur in the absence of physiological signals from the lungs or airways. A Bayesian model is now proposed, in which the brain generates sensations based on expectations learnt from past experiences (priors), which are then checked against incoming afferent signals. In this model, psychological factors may act as moderators. They may alter priors, change the relative attention towards incoming sensory information, or alter comparisons between priors and sensations, leading to more variable interpretation of an equivalent afferent input.In the present study we conducted a supplementary analysis of previously published data (Hayen et al., 2017). We hypothesised that individual differences in psychological traits (anxiety, depression, anxiety sensitivity) would correlate with the variability of subjective perceptions of equivalent breathlessness challenges. To better understand the resulting inferential leap in the brain, we explored where these behavioural measures correlated with functional brain activity across subjects.Behaviourally, anxiety sensitivity was found to positively correlate with each subject's variability of intensity and unpleasantness during mild breathlessness, and with variability of unpleasantness during strong breathlessness. In the brain, anxiety sensitivity was found to negatively correlate with precuneus activity during anticipation, positively correlate with anterior insula activity during mild breathlessness, and negatively correlate with parietal sensorimotor areas during strong breathlessness.Our findings suggest that anxiety sensitivity may reduce the robustness of this Bayesian sensory perception system, increasing the variability of breathlessness perception and possibly susceptibility to symptom misinterpretation. These preliminary findings in healthy individuals demonstrate how differences in psychological function influence the way we experience bodily sensations, which might direct us towards better understanding of symptom mismatch in clinical populations.

show abstract

Development of a dyspnoea word cue set for studies of emotional processing in COPD

Cited by 26 publications

References 27 publications

Treating the lungs via the brain: Mechanisms underpinning improvements in breathlessness with pulmonary rehabilitation

Treating the lungs via the brain: Mechanisms underpinning improvements in breathlessness with pulmonary rehabilitation

A wider pathological network underlying breathlessness and respiratory failure in amyotrophic lateral sclerosis

Breathlessness and the body: Neuroimaging clues for the inferential leap

Contact Info

Product

Resources

About