Subjective and objective assessment of oxaliplatin-induced peripheral neuropathy

Abstract

Numbness and pain are currently evaluated using subjective methods such as the visual analog scale (VAS). However, because assessment of pain can vary greatly depending on the mood and physical state of the patient at the time of assessment, it is best to evaluate pain objectively. pain vision PS-2100 (PV) is an analytical instrument that was designed to quantitatively and objectively assess sense perception and nociception in patients. The present study examined the correlation of subjective and objective assessment of oxaliplatin-induced peripheral neuropathy (PN) using VAS and PV, respectively. The mean VAS and PV scores of PN were 20.5 (range 0–100) and 27.9 (range 0–416), respectively. The partial correlation coefficient was 0.274 (p = 0.0003). No strong correlation was observed between the results and a weak correlation was observed between VAS and PV.

Objective evaluation of oxaliplatin-induced vascular pain secondary to peripheral vein administration

“…Subjects were instructed to indicate the strength of pain at the time of assessment by marking on a 100 mm horizontal line anchored with “0 (no pain)” on the left edge and “100 (worst pain imaginable)” on the right edge (Yoshida et al 2015c). …”

“…The PV was developed in clinical practice for quantitative analysis of pain perception (Matsumura et al 2012; Lee et al 2014; Ohtori et al 2014; Hiraki et al 2014; Kim et al 2014; Fukada et al 2011; Yoshida et al 2015c). PV is an analytical device that was designed to objectively and quantitatively assess patient sense nociception and perception.…”

“…Its advantages include the ability to evaluate pain relatively rapidly and without causing additional pain to the patient. Although we reported that VAS and PV are useful to evaluate oxaliplatin-induced peripheral neuropathy with the aim of aiding treatment (Yoshida et al 2015c), there have been no reports concerning the use of these measures for the assessment of VP due to oxaliplatin. Therefore, the purpose of this study was to identify potential correlations between the results of subjective and objective assessment methods to evaluate oxaliplatin-induced VP as measured using PV and VAS, respectively.…”

A simple method of quantifying chemotherapy‐induced peripheral neuropathy using PainVision PS‐2100®

“…As it appears likely that the symptomatic arm is mostly on the dominant side, we recommend that PV measurements should be taken on that side. Yoshida et al used PV to evaluate oxaliplatin‐induced CIPN. Fifty‐eight patients were subjected to an evaluation using visual analog scale and PV measurements, but only a slight correlation was observed, indicating no strong link, although the result indicated that objective evaluation using PV could help in the diagnosis of CIPN, and provide further evidence for clinical tests in the future.…”

Analgesia by sacral surface electrical stimulation for primary dysmenorrhoea

“…This research was conducted with approval from the ethics committee of Tohoku Bunka Gakuen University (approval number [16][17][18][19][20][21][22][23]. Participants received written information explaining the purpose of the study, and informed consent was obtained from all participants included in the study.…”