Subgingival instrumentation for treatment of periodontitis. A systematic review

Suvan, JE; Leira, Yago; Moreno, Federico; Graziani, Filippo; Derks, Jan; Tomasi, Cristiano

doi:10.1111/jcpe.13245

Cited by 189 publications

(206 citation statements)

References 53 publications

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“…Interestingly, a recent systematic review and meta-analysis observed similar clinical improvements following NSPT with different methodologies. 41 The clinical outcomes following NSPT with sonic/ ultrasonic versus hand instruments were similar, as were the clinical outcomes following quadrant-wise versus full-mouth NSPT. 41 In the present review, variations were observed between studies for the methodology employed for NSPT; however, as these variations do not affect the clinical outcomes, we would expect they would not affect the levels of expression of GCF markers.…”

Section: Discussionmentioning

confidence: 76%

Expression of inflammatory biomarkers and growth factors in gingival crevicular fluid at different healing intervals following non‐surgical periodontal treatment: A systematic review

Koidou

Cavalli

Hagi‐Pavli

et al. 2020

J of Periodontal Research

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Background: Non-surgical periodontal treatment (NSPT) is widely employed for the treatment of periodontal disease and yields significant clinical improvements. Gingival crevicular fluid (GCF) can be used to profile health and disease, and recent technological advances, such as multiplex bead immunoassays, are promising in identifying a wider array of GCF factors with the ultimate aim to predict the treatment response. Objective: The aim of this systematic review was to compare the expression of GCF markers using multiplex bead immunoassays before treatment and during early, average, or late healing period, following non-surgical periodontal treatment (NSPT). Methods: An electronic literature search was conducted by two independent examiners (VK and NC) in MEDLINE, EMBASE, OpenGrey, LILACS, and Cochrane Library up to January 2020. The PICO question formulated was as follows: "In patients with periodontal disease, does the expression of gingival crevicular fluid (GCF) markers detected using multiplex bead immunoassay differ at baseline compared with early (≤30 days), average (6-8 weeks), or late (≥3 months) healing after intervention?" Results: A total of 366 publications were obtained and reviewed for eligibility for inclusion. Of these, 12 publications fulfilled the inclusion criteria and were included in the present review. Data for a total of 31 different GCF markers were extracted and summarized for early, average, or late healing after NSPT. Early healing following NSPT (≤ 30 days) indicated an increase in IL-1β, TNFα, and IL-10. At the average healing period (6-8 weeks), IL-1β, IL-1α, IL-6, TNF-α, IFN-γ, GM-CSF, MCP-1, and MIP-1α were all reduced, compared to their respective baseline values. Three months after NSPT, IL-1β, IL-4, IL-6, IL-10, TNF-α, and IFN-γ were detected at reduced levels, compared to pre-treatment levels. Overall, the changes following treatment indicated a reduction of inflammation present at baseline. Conclusion: Following non-surgical periodontal treatment, an upregulation of inflammation markers is noted early post-operatively and a subsequent reduction of their levels three months following treatment. The investigation of levels of GCF markers associated with inflammation and regeneration, especially using multiplex bead

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Section: Discussionmentioning

confidence: 76%

Expression of inflammatory biomarkers and growth factors in gingival crevicular fluid at different healing intervals following non‐surgical periodontal treatment: A systematic review

Koidou

Cavalli

Hagi‐Pavli

et al. 2020

J of Periodontal Research

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“…A recent systematic review and meta-analysis has indeed confirmed that high probing pocket depth, smoking, and molar teeth are all associated with a higher risk of tooth loss [13]. Nonetheless, non-surgical periodontal management through scaling and root planning supplemented by the use of adjuncts, such as nutraceutical agents, has been demonstrated to result in a significant reduction in probing depth, bleeding on probing, level of inflammatory mediators, as well as short-term pain in periodontitis patients [14,15]. The presence of extensive subgingival caries involving the furcation area of tooth 46, however, made the tooth unrestorable and complicated the prognosis of any non-surgical periodontal management.…”

Section: Discussionmentioning

confidence: 97%

Monitoring Alveolar Ridge Remodelling Post-Extraction Using Sequential Intraoral Scanning over a Period of Four Months

Ahmed

2020

IJERPH

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The potential applications of computer-aided design/computer-aided manufacturing (CAD/CAM) and intraoral scanning exceed the delivery of standard prosthodontic interventions. The aim of this study was to clinically present a developed assessment technique, that relies on the use of sequential intraoral scanning, three-dimensional superimposition, and 2D and 3D deviation analyses based on a standardised protocol, as an auxiliary tool in monitoring dimensional changes of residual ridge post-extraction with a follow-up period of four months.

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“…Non-surgical periodontal therapy is the first step for any patient affected with periodontitis. The desegregation of the bacterial biofilm at PD sites provides a reduction of PDs and inflammation, especially in PDs ≤ 6 mm [12,13] . If the number of residual pockets is limited and inflammation is under control, patients are expected to experience limited tooth loss (0.1 tooth/patient/year [14] ) throughout a lifelong supportive care program, which is generally enough to prevent masticatory dysfunction.…”

Section: Introductionmentioning

confidence: 99%

Stem cells and periodontal regeneration: present and future

Citterio¹,

Gualini²,

Fierravanti³

et al. 2020

Plast Aesthet Res

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The ultimate goal of periodontal regeneration is to restore the damaged alveolar bone proper, root cementum, and periodontal ligament with collagen fibers inserted into the root surface. The search for new regenerative strategies is a challenging field of periodontal research, and tissue engineering, using stem cells, has recently been shown as a promising approach. This paper aims at reviewing the current available literature on the use of stem cells for the treatment of periodontitis. Up to now, different mesenchymal stem cells (MSCs) have shown potential for periodontal regeneration in animal studies. The most investigated MSCs for periodontal regeneration are bone marrow MSCs (BMMSCs), periodontal ligament stem cells (PDLSCs), and dental pulp stem cells (DPSCs), which have shown very promising results in animal models. Few studies on humans are available but BMMSCs, PDLSCs, and DPSCs have been proven safe and effective. Clinical trials are sparse, but tend to support the efficacy of MSCs for periodontal regeneration. In the future, more human studies will be required to support the use of MSCs in daily clinical practice, especially in order to identify the best protocol to harvest, process, and graft MSCs. Future perspectives include trans-differentiation of somatic cells to generate induced pluripotent stem cells, homing procedures, the use of exogenous stem cells, and 3D-printed scaffolds.

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Subgingival instrumentation for treatment of periodontitis. A systematic review

Cited by 189 publications

References 53 publications

Expression of inflammatory biomarkers and growth factors in gingival crevicular fluid at different healing intervals following non‐surgical periodontal treatment: A systematic review

Expression of inflammatory biomarkers and growth factors in gingival crevicular fluid at different healing intervals following non‐surgical periodontal treatment: A systematic review

Monitoring Alveolar Ridge Remodelling Post-Extraction Using Sequential Intraoral Scanning over a Period of Four Months

Stem cells and periodontal regeneration: present and future

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