Subgingival Chlorhexidine Varnish Administration as an Adjunct to Same‐Day Full‐Mouth Root Planing. I. Clinical Observations

Cosyn, Jan; Wyn, Iris; Rouck, Tim De; Sabzevar, Mehran Moradi

doi:10.1902/jop.2007.060221

Cited by 33 publications

(42 citation statements)

References 49 publications

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“…All patients gave informed consent. Demographic details and study design are described in an accompanying paper reporting clinical observations 20 . Briefly, subjects in the control group received full‐mouth SRP completed in 12 hours using an ultrasonic scaler and standard periodontal curets, including polishing and oral hygiene instructions.…”

Section: Methodsmentioning

confidence: 99%

“…Recent studies indicated beneficial clinical effects when 35% (weight/volume [w/v]) chlorhexidine (CHX) varnish † was applied subgingivally as an adjunct to SRP performed in two stages 17,18 . Similar, yet less marked, effects were shown using this antimicrobial agent adjunctive to same‐day full‐mouth root planing 19,20 . The hypothesis behind these treatment strategies lies in the ability of the varnish to increase/prolong microbiological improvements of SRP.…”

mentioning

confidence: 99%

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Subgingival Chlorhexidine Varnish Administration as an Adjunct to Same‐Day Full‐Mouth Root Planing. II. Microbiological Observations

Cosyn¹,

Sabzevar²

2007

Journal of Periodontology

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Section: Methodsmentioning

confidence: 99%

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confidence: 99%

Subgingival Chlorhexidine Varnish Administration as an Adjunct to Same‐Day Full‐Mouth Root Planing. II. Microbiological Observations

Cosyn¹,

Sabzevar²

2007

Journal of Periodontology

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“…However, at present, chlorhexidine (CHX) represents the gold standard among the disinfectants used for the treatment of periodontal and peri-implant infections. Chlorhexidine is active against many microbial species [13][14][15], but it may exert some cytotoxic effect as shown in some in vitro studies [16,17]. Furthermore, the antimicrobial activity of chlorhexidine is strongly reduced in the presence of serum [18], which in turn, limits its effectiveness in the subgingival environment.…”

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confidence: 99%

Efficacy of taurolidine against periodontopathic species—an in vitro study

et al. 2011

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The antimicrobial effect of taurolidine was tested against periodontopathic species in comparison to chlorhexidine digluconate in the presence or absence of serum. Minimal inhibitory concentrations (MIC), microbiocidal concentrations (MBC), as well as killing were determined against 32 different microbial strains including 3 Porphyromonas gingivalis, 3 Aggregatibacter actinomycetemcomitans, and 15 potentially superinfecting species with and without 25% v/v human serum. The MIC 50 of taurolidine against the tested microbial strains was 0.025% and the MIC 90 0.05%. The respective values for the MBCs were 0.05% and 0.1%. Addition of 25% serum (heat-inactivated) did not change the MIC and MBC values of taurolidine. In contrast, MICs and MBCs of chlorhexidine (CHX) increased by two steps after addition of serum. Taurolidine killed microorganisms in a concentration and timedependent manner, the killing rate of 1.6% taurolidine was 99.08%±2.27% in mean after 2 h. Again, killing activity of taurolidine was not affected if serum was added, whereas addition of inactivated serum clearly reduced the killing rate of all selected bacterial strains by CHX. Therefore, taurolidine possesses antimicrobial properties which are not reduced in the presence of serum as a main component in gingival crevicular fluid and wound fluid. Taurolidine may have potential as an antimicrobial agent in non-surgical and surgical periodontal treatment.

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“…To enhance the efficacy of non-surgical therapy a chemo-mechanical treatment concept was introduced based on sequential SRP and the adjunctive subgingival administration of 35% CHX varnish[5] and subgingival placement of a biodegradable CHX chip,[6] which biodegrades and releases CHX within the pocket over 7-10 days maintaining an average concentration in the GCF greater than 12 mg/ml for 8 days.…”

Section: Introductionmentioning

confidence: 99%

Comparison of the efficacy of chlorhexidine varnish and chip in the treatment of chronic periodontitis

et al. 2013

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Background:The purpose of this study was to clinically evaluate the benefits of sub gingival chlorhexidine (CHX) varnish and biodegradable CHX chip application used as an adjunct to scaling and root planning (SRP) as combined therapy and also to compare the effect of combined therapy with SRP alone.Materials and Methods:Fifteen patients with at least three sites with a probing pocket depth (PPD) of 5-8 mm were considered. Following baseline evaluation, all three sites were subjected for SRP. After completing SRP, each site was randomly subjected for CHX varnish, CHX chip application and the 3rd site was left without any medication as a control. Clinical parameters such as sulcus bleeding index, plaque index, bleeding on probing (BOP), PPD, and clinical attachment level (CAL) were recorded at baseline, 1 month and 3 months post-operatively.Results:All three groups presented with an improvement in clinical parameters compared to baseline. The mean reduction in PPD was 2.4 mm in SRP sites, 2.5 mm in SRP + CHX varnish sites and 2.8 mm in SRP + CHX chip sites. The mean gain in CAL was 2.4 mm in SRP sites, 2.3 mm in SRP + CHX varnish sites and 2.8 mm SRP + CHX chip sites.Interpretation and Conclusion:The present study indicated that application of CHX varnish and placement of CHX chip as an adjunct to SRP produced a clinically significant reduction in the PPD, BOP and a gain in CAL at 30th day and 90th day from baseline when compared to SRP alone. The results though were not statistically significant.

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Subgingival Chlorhexidine Varnish Administration as an Adjunct to Same‐Day Full‐Mouth Root Planing. I. Clinical Observations

Abstract: The outcome of same-day full-mouth root planing may benefit from the subgingival administration of a highly concentrated chlorhexidine varnish, at least in terms of pocket reduction in initially deep sites (>or=7 mm).

Cited by 33 publications

References 49 publications

Subgingival Chlorhexidine Varnish Administration as an Adjunct to Same‐Day Full‐Mouth Root Planing. II. Microbiological Observations

Subgingival Chlorhexidine Varnish Administration as an Adjunct to Same‐Day Full‐Mouth Root Planing. II. Microbiological Observations

Efficacy of taurolidine against periodontopathic species—an in vitro study

Comparison of the efficacy of chlorhexidine varnish and chip in the treatment of chronic periodontitis

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