Subfoveal Choroidal Thickness: The Beijing Eye Study

Wei, Wen Bin; Xu, Liang; Jonas, Jost B.; Shao, Lei; Du, Kui Fang; Wang, Shuang; Chen, Chang Xi; Xu, Jie; Wang, Ya Xing; Zhou, Jin; You, Qi Sheng

doi:10.1016/j.ophtha.2012.07.048

Cited by 514 publications

(425 citation statements)

References 23 publications

Supporting

Mentioning

358

Contrasting

Unclassified

Order By: Relevance

“…Thus, the present finding possibly can be explained by increased choroidal thickness in males than females. 22,23 Among the other results, the MD of VF showed a significant negative association with overall PLCD in the The average RNFL thickness showed significant association with overall PLCD in univariate analysis but not in multivariate analysis. The PLCD measurement was performed at the central three of the five cross-line scans with 0.25-mm spacing at each meridian.…”

Section: Discussionmentioning

confidence: 78%

Peripheral lamina cribrosa depth in primary open-angle glaucoma: a swept-source optical coherence tomography study of lamina cribrosa

Kim

Jeoung

et al. 2015

Eye

View full text Add to dashboard Cite

Purpose To investigate peripheral lamina cribrosa depth (PLCD) and its verticalhorizontal difference in eyes with primary open-angle glaucoma (POAG). Methods Patients with POAG (n = 90 eyes) and age-matched healthy individuals (n = 90 eyes) underwent swept-source optical coherence tomography (SS-OCT) scans centered at the optic discs. The PLCD was defined as the vertical distance between the most peripheral visible end of anterior lamina cribrosa (LC) surface and the reference plane connecting the Bruch's membrane openings. The PLCD in each quadrant region and the vertical-horizontal PLCD difference were compared between the POAG and healthy eyes. The clinical factors associated with increased PLCD were evaluated. Results The PLCD was significantly larger in the POAG eyes than the control eyes at the horizontal (P = 0.034) and vertical (P = 0.001) meridians. The vertical PLCD was significantly larger than the horizontal PLCD, both in the POAG eyes (Po0.001) and in the control eyes (P = 0.003). However, the vertical-horizontal PLCD difference was significantly larger in the POAG eyes (47 ± 60 μm) than in the control eyes (18 ± 54 μm, P = 0.001). Multivariate regression showed a significant association of male gender (P = 0.005), increased baseline IOP (P = 0.043), and decreased MD of VF (P = 0.025) with increased PLCD. Conclusions The peripheral LC was displaced more posteriorly in the POAG eyes compared with the age-matched healthy eyes. In the POAG eyes, the peripheral LC was displaced more posteriorly at the vertical meridian than at the horizontal meridian. The peripheral LC in the vertical meridian might have increased IOP-related strain (deformation) compared with horizontal meridian in glaucomatous eyes.

show abstract

Section: Discussionmentioning

confidence: 78%

Peripheral lamina cribrosa depth in primary open-angle glaucoma: a swept-source optical coherence tomography study of lamina cribrosa

Kim

Jeoung

et al. 2015

Eye

View full text Add to dashboard Cite

show abstract

“…29,30 Large populationbased studies found significant correlation between increased age and increased axial length with decreased choroidal thickness. [30][31][32][33][34] Furthermore, the diminution in choroidal thickness with age was approximately the same in absolute quantities in highly myopic eyes as in eyes without high myopia. 35 When highly myopic eyes grow with age, the choroid may become very thin and even completely absent.…”

Section: Choroidmentioning

confidence: 78%

Advances of optical coherence tomography in myopia and pathologic myopia

Cheung

Luk

et al. 2016

Eye

View full text Add to dashboard Cite

show abstract

“…Correspondingly, scleral thickness measurements at or posterior to the equator were not significantly correlated with corneal thickness measurements, fitting with clinical studies in which central corneal thickness was not related with axial length. 18 In the highly axially myopic group of globes, scleral thinning at the posterior pole and thinning of the peripapillary scleral flange were significantly correlated with thinning of the lamina cribrosa. Interestingly, globes with secondary high axial myopia due to congenital glaucoma showed a tendency to a thinning of the sclera in all regions including the region anterior to the cornea.…”

Section: Histological Changes In High Axial Myopia: Scleramentioning

confidence: 86%

Histological changes of high axial myopia

Jonas

2013

Eye

129

View full text Add to dashboard Cite

To describe pathological changes in the anatomy of highly myopic (axially elongated) eyes, enucleated globes were examined by light microscopy and ocular structures were measured histomorphometrically. These studies revealed that highly axially myopic eyes show continuous thinning of the sclera starting at or behind the equator with a maximal thinning at the posterior pole; a profound thinning of the choroid decreasing from B250 to o10 mm in extreme axial myopia, secondary macular defects in the Bruch's membrane associated with a complete loss of retinal pigment epithelium and choriocapillaris, and retinal photoreceptors; a Bruch's membrane of normal thickness in contrast to the profound thinning of the choroid and the sclera; an up to 10-fold elongation and thinning of the peripapillary scleral flange as anterior roof of the orbital cerebrospinal fluid space, and subsequently a retrobulbar extension of the cerebrospinal fluid space; an increased distance of the peripapillary arterial circle of Zinn-Haller to the optic disc border; an elongation and thinning of the lamina cribrosa with a subsequently decreased distance between the intraocular pressure compartment and the retrobulbar orbital cerebrospinal fluid pressure compartment; an increasing exposure of the peripheral posterior lamina cribrosa surface to the cerebrospinal fluid space, no longer buffered by the solid optic nerve tissue; and the development and enlargement of parapapillary gamma zone, in contrast to a myopia-independent parapapillary beta zone. These anatomical changes may be associated with high axial myopia-related complications such as an increased susceptibility of glaucomatous optic neuropathy and myopic retinopathy.

show abstract

Subfoveal Choroidal Thickness: The Beijing Eye Study

Cited by 514 publications

References 23 publications

Peripheral lamina cribrosa depth in primary open-angle glaucoma: a swept-source optical coherence tomography study of lamina cribrosa

Peripheral lamina cribrosa depth in primary open-angle glaucoma: a swept-source optical coherence tomography study of lamina cribrosa

Advances of optical coherence tomography in myopia and pathologic myopia

Histological changes of high axial myopia

Contact Info

Product

Resources

About