Subfoveal Choroidal Thickness in Central Serous Chorioretinopathy: A Meta-Analysis

Chen, Guohai; Tzekov, Radouil; Li, Wensheng; Jiang, Fangzheng; Mao, Sihong; Tong, Yuhua

doi:10.1371/journal.pone.0169152

Cited by 37 publications

(32 citation statements)

References 43 publications

(57 reference statements)

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“…29,30 Similarly, findings from a metaanalysis of studies among CSCR patients revealed SCT values to range from 414 AE 109.0 to 61.4 AE 101.4 μm in the affected eyes and from 350.9 AE 116 to 387 AE 94 μm in the control eyes. 31 In our study, there was no significant correlation between SCT and visual acuity either at baseline or following spontaneous resolution. Similarly, in a study by Yalcinbayir et al, 4 the authors reported no significant association between SCT and visual acuity in patients with CSCR and emphasised the likelihood of choroidal thickness not to be among the primary determinants of visual acuity, despite its important role in the pathophysiology of CSCR.…”

Section: Discussioncontrasting

confidence: 63%

Pattern electroretinography in patients with unilateral acute central serous chorioretinopathy

Doğuizi

Şekeroğlu

Ozkoyuncu

et al. 2020

Clinical and Experimental Optometry

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Background To evaluate the pattern electroretinography (PERG) in patients with acute central serous chorioretinopathy (CSCR) at baseline and after spontaneous resolution. Methods A total of 32 patients (mean ± SD age: 38.8 ± 8.2 years, 71.9 per cent female) with unilateral acute CSCR and spontaneous resolution during follow‐up period were included. The unaffected eyes of the study patients comprised the control group. The best‐corrected visual acuity, PERG and optical coherence tomography findings were recorded both at baseline and following spontaneous resolution at two to four months. Results The P50 and N95 amplitudes of the affected eyes were significantly lower than the control group both at baseline and after CSCR resolution (p < 0.001 for each). A significant increase was noted in both P50 and N95 amplitudes of the affected eyes from baseline to post‐resolution (p < 0.001 for each). Subfoveal choroidal thickness was significantly higher in the affected eyes as compared with control eyes both at the baseline and after CSCR resolution along with a significant decrease in the affected eyes from baseline to post‐resolution (p < 0.001 for each). The central retinal thickness was higher in the affected eyes as compared with the control eyes at baseline (p = 0.009), along with a significant decrease in the affected eyes from baseline to post‐resolution (p < 0.001). Between the baseline P50 amplitude and the visual acuities of the affected eyes, a strong correlation was noted at baseline (r = −0.691, p < 0.001) and a moderate correlation was noted after CSCR resolution (r = −0.422, p = 0.031). Conclusions In conclusion, our findings revealed an association of CSCR with impaired P50 and N95 amplitudes and a significant improvement but not a complete recovery in both parameters after CSCR resolution. Our findings emphasise potential utility of PERG in the electrophysiological evaluation of functional impairment in CSCR patients and the likelihood of P50 amplitude to have a prognostic value in CSCR.

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Section: Discussioncontrasting

confidence: 63%

Pattern electroretinography in patients with unilateral acute central serous chorioretinopathy

Doğuizi

Şekeroğlu

Ozkoyuncu

et al. 2020

Clinical and Experimental Optometry

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“…Choroidal imaging of almost all eyes with active CSCR as well as some asymptomatic fellow eyes shows subfovealchoroidal thickening and dilated choroidal vessels. [ 72 ] Chronic CSCR is believed to be part of the pachychoroid spectrum. Other features described include thinning of the inner choroidal vessels, focal choroidal excavation[ 73 74 75 ] (defined as a macular lesion with choroidal excavation detected on SD-OCT without evidence of scleral ectasia or posterior staphyloma), and loculation of fluid in the posterior choroid.…”

Section: Optical Coherence Tomography In Conditions Causing Serous Dementioning

confidence: 99%

Optical coherence tomography: A guide to interpretation of common macular diseases

Bhende¹,

Shetty²,

Parthasarathy

et al. 2018

Indian J Ophthalmol

105

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Optical coherence tomography is a quick, non invasive and reproducible imaging tool for macular lesions and has become an essential part of retina practice. This review address the common protocols for imaging the macula, basics of image interpretation, features of common macular disorders with clues to differentiate mimickers and an introduction to choroidal imaging. It includes case examples and also a practical algorithm for interpretation.

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“…Also, choroidal thickness is abnormal in conditions, such as glaucoma, 5 diabetic retinopathy, 6 amblyopia, 7 and central serous chorioretinopathy. 8 Thus, it is involved in several visual disorders, but sparse information exists on the normal changes in choroidal thickness through life. Only within the most recent decade has means of in vivo quantification of choroidal thickness been available 9 and most of the current data are limited to cross-sectional studies.…”

mentioning

confidence: 99%

Five-Year Change in Choroidal Thickness in Relation to Body Development and Axial Eye Elongation: The CCC2000 Eye Study

Hansen

Larsen

et al. 2019

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. We describe changes in choroidal thickness from age 11 to 16 years and its association with ocular biometrics and body development. METHOD. In this longitudinal, population-based observational study, choroidal thickness was measured subfoveally and 1-and 3-mm temporal thereof using enhanced depth imaging spectral domain optical coherence tomography. Analyses were stratified by sex and adjusted for age and the time of day that the scan was performed. RESULTS. The study included 687 participants (304 boys). Median (interquartile range [IQR]) age was 11.5 (0.6) years at baseline and 16.6 (0.3) years at follow-up. Mean increase in choroidal thickness was 33, 27, and 11 lm at the three respective locations. The subfoveal choroid thickened less in eyes whose axial length increased more (boys, b ¼ À85 lm/mm; 95% confidence interval [CI], À104 to À66, P < 0.0001; girls, b ¼ À105 lm/mm; 95% CI, À121 to À89, P < 0.0001) and in eyes with a more negative refractive development (boys, 11 lm/diopters [D]; 95% CI, 4.0 to 18, P ¼ 0.0022; girls, 22 lm/D; 95% CI, 16 to 27, P < 0.0001). Subfoveal choroidal thickness increased less in girls who underwent early puberty (Tanner stage 4 vs. 1; À39 lm' 95% CI, À72 to À5.9, P ¼ 0.021) and who had a longer baseline axial length (b ¼ À8.6 lm/mm; 95% CI, À15 to À2.7, P ¼ 0.0043), and more in girls who grew taller (b ¼ 0.9 lm/cm; 95% CI, 0.1 to 1.7, P ¼ 0.026). CONCLUSIONS. The choroid increased in thickness from age 11 to 16 years. The increase was greater in girls with later sexual maturation and smaller in eyes that added more axial length and had a relatively negative refractive development.

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Subfoveal Choroidal Thickness in Central Serous Chorioretinopathy: A Meta-Analysis

Cited by 37 publications

References 43 publications

Pattern electroretinography in patients with unilateral acute central serous chorioretinopathy

Pattern electroretinography in patients with unilateral acute central serous chorioretinopathy

Optical coherence tomography: A guide to interpretation of common macular diseases

Five-Year Change in Choroidal Thickness in Relation to Body Development and Axial Eye Elongation: The CCC2000 Eye Study

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