Subcutaneous testosterone implant therapy improves endothelium-dependent and independent vasodilation in postmenopausal women already receiving oestrogen

Worboys, Samantha; Kotsopoulos, Dimitra; Teede, Helena; McGrath, Brendan; Davis, Shelly

doi:10.1046/j.1443-9506.2000.06760.x

Cited by 5 publications

(7 citation statements)

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“…Chronic testosterone therapy improves vasomotor function in estrogenized, postmenopausal women. 12 Acutely supraphysiological testosterone administration enhances vaginal pulse amplitude and self-reported sexual responsiveness to erotic videos in young eugonadal women. 32 Hence, testosterone may also improve sexual responsiveness by enhancing vaginal blood flow and lubrication.…”

Section: Discussionmentioning

confidence: 99%

Transdermal testosterone therapy improves well-being, mood, and sexual function in premenopausal women

et al. 2003

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Objective: Circulating testosterone in women declines during the late reproductive years such that otherwise healthy women in their 40s have approximately half the testosterone level as women in their 20s. Despite this, research showing the benefits of androgen replacement has been limited to the postmenopausal years. In view of the known premenopausal physiological decline in testosterone, we have evaluated the efficacy of transdermal testosterone therapy on mood, well-being, and sexual function in eugonadal, premenopausal women presenting with low libido.Design: Premenopausal women with low libido participated in a randomized, placebocontrolled, crossover, efficacy study of testosterone cream (10 mg/day) with two double-blind, 12-week, treatment periods separated by a single-blind, 4-week, washout period.Results: Thirty-four women completed the study per protocol, with 31 women (mean age 39.7 ± 4.2 years; serum testosterone 1.07 + 0.50 nmol/L) providing complete data. Testosterone therapy resulted in statistically significant improvements in the composite scores of the Psychological General Well-Being Index [+12.9 (95% CI, +4.6 to +21.2), P = 0.003] and the Sabbatsberg Sexual Self-Rating Scale [+15.7 (95% CI, +6.5 to +25.0), P = 0.001] compared with placebo. A mean decrease in the Beck Depression Inventory score approached significance [−2.8 (95% CI, −5.7 to +0.1), P = 0.06]. Mean total testosterone levels during treatment were at the high end of the normal range, and estradiol was unchanged. No adverse effects were reported.Conclusions: Testosterone therapy improves well-being, mood, and sexual function in premenopausal women with low libido and low testosterone. As a substantial number of women experience diminished sexual interest and well-being during their late reproductive years, further research is warranted to evaluate the benefits and safety of longer-term intervention.

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Section: Discussionmentioning

confidence: 99%

Transdermal testosterone therapy improves well-being, mood, and sexual function in premenopausal women

et al. 2003

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“…Following treatment with combined subcutaneous implants with estradiol 40 mg and T 100 mg, no significant changes were seen in total serum cholesterol, triglyceride or cholesterol subfractions (Burger et al, 1984). There is no evidence that parenteral testosterone therapy has adverse cardiovascular effects (Goodman-Gruen and Bernini et al, 1999;Davis et al, 2000;Worboys et al, 2001). Conversely, it has been suggested that parenteral T therapy may be associated with improved cardiovascular risk (Yue et al, 1995;Worboys et al, 2001).…”

Section: Cardiovascular Effectsmentioning

confidence: 99%

“…Androgens also play a role in the arousal phase of the female sexual response by inducing vaginal vaso-congestion during sexual arousal (Tuiten et al, 1996;Sarrel et al, 1998;Tuiten et al, 2000). Testosterone appears to be important for its vasomotor effects (Worboys et al, 2001), enhancing vaginal blood flow and lubrication (Leiblum et al, 1983;Tuiten et al, 2000). These effects may be due to direct androgen actions or be due in part to estradiol biosynthesis from testosterone in the vascular bed (Harada et al, 1999).…”

Section: Vaginal Blood Flowmentioning

confidence: 99%

“…There is no evidence that parenteral testosterone therapy has adverse cardiovascular effects (Goodman-Gruen and Bernini et al, 1999;Davis et al, 2000;Worboys et al, 2001). Conversely, it has been suggested that parenteral T therapy may be associated with improved cardiovascular risk (Yue et al, 1995;Worboys et al, 2001). There is evidence also that endogenous androgen levels are inversely related to carotid artery wall thickness, a marker of atherosclerosis (Bernini et al, 1999).…”

Section: Cardiovascular Effectsmentioning

confidence: 99%

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Androgen insufficiency in women: diagnostic and therapeutic implications

Rivera-Woll¹,

Papalia²,

Davis³

et al. 2004

Human Reproduction Update

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The proposed key symptoms of the female androgen insufficiency syndrome (FAIS) include reduced libido, diminished well being and lowered mood. The diagnosis of FAIS is made on the basis of these symptoms in the setting of a low serum free testosterone level. However, there is currently no readily available inexpensive assay which reliably measures free testosterone levels in the female range. The diagnosis of FAIS is further complicated by the lack of data demonstrating a minimum serum free testosterone level which, if below this, correlates with the symptoms of FAIS. Despite the complexities involved with defining FAIS, the symptoms have been reported to respond well to testosterone replacement. There is a need for formulations of testosterone therapy specifically designed for use in women, along with clear guidelines regarding optimal therapeutic doses and long-term safety data.

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“…Estrogens have a direct effect on peripheral blood flow, neurogenic mechanisms, and improvement in vaginal lubrication [34]. Testosterone also plays a role and has been shown to affect vasomotor mechanisms [35], which may enhance vaginal blood flow and lubrication [36]. Some effects may result from aromatization of testosterone to estradiol, but vaginal tissue has been postulated to contain a specific nuclear receptor for the powerful androgen ∆5 androstenediol [37].…”

Section: Sex Hormones and Sexual Arousalmentioning

confidence: 99%

Androgens are vital to female sexual health

Guay

2004

Curr sex health rep

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Subcutaneous testosterone implant therapy improves endothelium-dependent and independent vasodilation in postmenopausal women already receiving oestrogen

Cited by 5 publications

References 0 publications

Transdermal testosterone therapy improves well-being, mood, and sexual function in premenopausal women

Transdermal testosterone therapy improves well-being, mood, and sexual function in premenopausal women

Androgen insufficiency in women: diagnostic and therapeutic implications

Androgens are vital to female sexual health

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