Subcutaneous T-cell lymphoma with associated hemophagocytic syndrome and terminal leukemic transformation

Aggressive subcutaneous panniculitis-like T-cell lymphoma with hemophagocytosis in two children (subcutaneous panniculitis-like T-cell lymphoma)

“…[38][39][40] Stem-cell transplantation after high-dose chemotherapy has been described, with impressive response rates. 1,6,26,[41][42][43][44][45] In the handful of cases of SPTCL described in pediatric patients (Table I), most were treated with multidrug chemotherapy with variable response and duration of remission. 2,5,12,15,17,46 The use of single-agent fludarabine has not been described before in a pediatric patient with SPTCL.…”

Successful treatment of refractory subcutaneous panniculitis-like T-cell lymphoma with allogeneic peripheral blood stem cell transplantation from HLA-mismatched sibling donor

“…It is considered as a cytotoxic T-cell neoplasm with cyotoxic granules and can be cytochemically identified using granzyme B, perforin or TIA-1 [2]. Some cases of SPTCL might be indolent for months or years, but SPTL frequently has an aggressive course, and is often complicated by fatal hemophagocytic syndrome (HPS) [3].…”

High-dose chemotherapy with autologous blood stem cell transplantation for aggressive subcutaneous panniculitis-like T-cell lymphoma

“…4 Although about half of patients with SPTCL treated with chemotherapy and/or radiotherapy achieve complete remissions, mortality has been reported to be as high as 81%. 5 Autologous stem cell transplantation has been described only in a few patients with SPTCL. [6][7][8][9][10] In this letter, we report a patient diagnosed with aggressive SPTCL successfully treated with autologous peripheral blood stem cell (PBSC) transplantation and review all the published cases of SPTCL treated with this therapeutic approach.…”