High-dose chemotherapy with autologous blood stem cell transplantation for aggressive subcutaneous panniculitis-like T-cell lymphoma

Subcutaneous panniculitis-like T-cell lymphoma: definition, classification, and prognostic factors: an EORTC Cutaneous Lymphoma Group Study of 83 cases

“…Since the WHO classification from 2001 did not yet distinguish between SPTL-AB and SPTL-GD and describes SPTL as an aggressive type of lymphoma, in most centers doxorubicinbased chemotherapy is the preferred type of treatment, sometimes in combination with alemtuzumab or followed by an auto-SCT. 21,23,24 The results of the present and other recent studies indicate that SPTL-ABs have an excellent prognosis, in particular when not complicated by a HPS. 8 Of the 52 SPTL-AB patients without HPS only 2 patients died, 1 from therapy-related side effects and 1 of unrelated disease.…”

“…Taken together, these results indicate that CHOP(-like) therapy is not very successful in patients with SPTL with associated HPS. High-dose chemotherapy followed by auto-SCT or allo-SCT has been suggested 21,24,25 In our study, 5 SPTL-AB patients underwent an auto-SCT (4 patients) or an allo-SCT (1 patient), and 3 of 5 patients achieved a complete remission. However, all 5 patients did not have associated HPS.…”

Subcutaneous Panniculitis-Like T-Cell Lymphoma (SPTCL) with Hemophagocytosis (HPS) : Successful Treatment Using High-Dose Chemotherapy (BFM-NHL ^|^amp; ALL-90) and Autologous Peripheral Blood Stem Cell Transplantation

“…Auto-SCT or allo-SCT following HDT has been suggested as an important option for patients with refractory or recurrent SPTCL. 4,14 In the present case, high-dose PSL was initially used, but no response was obtained. Therefore, we treated the patient according to the BFM-NHL & ALL-90 protocol.…”

Subcutaneous panniculitis‐like T‐cell lymphoma in the pediatric age group: A lymphoma of low malignant potential

“…This inconsistency in therapeutic regimens extends to both pediatric and adult cases reported in the literature. Additional strategies that were not known to have been used in our patients but have been reported include radiation 6 and autologous peripheral blood stem cell transplant 7. The rarity of this disease has prevented a unified treatment strategy from being developed.…”