Subcutaneous nodules and the differentiation of rheumatoid arthritis from rheumatic fever

Benedek, Thomas G.

doi:10.1016/0049-0172(84)90011-8

Cited by 20 publications

(3 citation statements)

References 49 publications

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“…The first histologic descriptions of subcutaneous nodules of ARF were published in the early 1880s, and the term "rheumatismus nodosus" was first used in 1885 [9]. The histologic appearance varies whether an early or an established nodule is biopsied.…”

Section: Histologic Featuresmentioning

confidence: 99%

“…The histologic appearance varies whether an early or an established nodule is biopsied. Features in early descriptions include increased numbers of dilated blood vessels with peripherally thickened walls, fibrinoid necrosis, and fibrosis with attachment to tendons [9]. They are histologically similar to nodules seen in rheumatoid arthritis with central fibrinoid necrosis, surrounded by histiocytes and perivascular lymphocytes and neutrophils [8].…”

Section: Histologic Featuresmentioning

confidence: 99%

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Acute Rheumatic Fever: A Review of Essential Cutaneous and Histological Findings

Heard

Green

Royer

2021

Cureus

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Acute rheumatic fever (ARF) is an autoimmune response that may occur after infection with group A Streptococcus . Clinical manifestations are protean, making the syndrome difficult to recognize in the 21st century. Secondary prophylaxis with benzathine penicillin is given for 10 years after an episode of ARF to prevent recurrence and reduce the risk of rheumatic heart disease. This case highlights the importance of providing a detailed clinical history to the dermatopathologist when considering ARF in the differential diagnosis.

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Section: Histologic Featuresmentioning

confidence: 99%

Section: Histologic Featuresmentioning

confidence: 99%

Acute Rheumatic Fever: A Review of Essential Cutaneous and Histological Findings

Heard

Green

Royer

2021

Cureus

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“…Subcutaneous nodules are characterized by their association with systemic disease, location, and histopathology and may suggest a specific underlying diagnosis [1][2][3]. On occasion, specific staining may reveal deposits of mucin, glycogen, cholesterol, and amyloid, suggesting the proper diagnosis.…”

Section: Introductionmentioning

confidence: 99%

Rheumatoid Nodulosis in a Patient with Lupus Erythematosus: Case Report and Review

Bautista

Restrepo

Matteson³

et al. 2007

CRR

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Nodules are commonly found in patients with rheumatic diseases, most often in rheumatoid arthritis, but also in other conditions such as systemic lupus erythematosus (SLE). Rheumatoid nodulosis, however, is less frequent and not an established feature of SLE. We describe a patient with SLE and rheumatoid nodulosis, reviewing the literature and suggest that this manifestation falls into the spectrum of rhupus.

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The Return of Acute Rheumatic Fever in Young Adults

Wallace

Garst²,

Papadimos³

et al. 1989

JAMA

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Subcutaneous nodules and the differentiation of rheumatoid arthritis from rheumatic fever

Cited by 20 publications

References 49 publications

Acute Rheumatic Fever: A Review of Essential Cutaneous and Histological Findings

Acute Rheumatic Fever: A Review of Essential Cutaneous and Histological Findings

Rheumatoid Nodulosis in a Patient with Lupus Erythematosus: Case Report and Review

The Return of Acute Rheumatic Fever in Young Adults

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