2021
DOI: 10.7759/cureus.12577
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Acute Rheumatic Fever: A Review of Essential Cutaneous and Histological Findings

Abstract: Acute rheumatic fever (ARF) is an autoimmune response that may occur after infection with group A Streptococcus . Clinical manifestations are protean, making the syndrome difficult to recognize in the 21st century. Secondary prophylaxis with benzathine penicillin is given for 10 years after an episode of ARF to prevent recurrence and reduce the risk of rheumatic heart disease. This case highlights the importance of providing a detailed clinical history to the dermatopathologist when cons… Show more

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Cited by 3 publications
(2 citation statements)
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“…However, although typical, it is recognized only in <6% of patients. Another cutaneous manifestation of RF are subcutaneous nodules 120,121 . Cutaneous symptoms are frequent in systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) , both manifesting sometimes with movement disorders (with chorea being the most common in both, and ataxia and parkinsonism less often in SLE) 122 .…”
Section: Skin Conditions In Hyperkinetic Movement Disordersmentioning
confidence: 99%
“…However, although typical, it is recognized only in <6% of patients. Another cutaneous manifestation of RF are subcutaneous nodules 120,121 . Cutaneous symptoms are frequent in systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) , both manifesting sometimes with movement disorders (with chorea being the most common in both, and ataxia and parkinsonism less often in SLE) 122 .…”
Section: Skin Conditions In Hyperkinetic Movement Disordersmentioning
confidence: 99%
“…Children between the ages of five and 15 are most frequently affected [ 2 ]. Studies have shown an association of ARF with low socioeconomic status, overpopulation, and rural areas with limited access to healthcare [ 3 ]. Carditis, arthritis, Sydenham's chorea, erythema marginatum, and subcutaneous nodules are the five major clinical symptoms of rheumatic fever that were first proposed by Dr. T Ducket Jones in 1944 [ 4 ].…”
Section: Introductionmentioning
confidence: 99%