Subcutaneous Mycetoma-like Granuloma in a Horse Caused by <i>Aspergillus Versicolor</i>

Keegan, Kevin G.; Dillavou, Clayton L.; Turnquist, Susan E.; Fales, William H.

doi:10.1177/104063879500700429

Cited by 14 publications

(10 citation statements)

References 6 publications

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“…Mycotoxins produced by A. versicolor such as sterigmatocystin have been shown to cause DNA damage in vitro and are potentially carcinogenic (36). A. versicolor has been implicated in a case of equine subcutaneous mycetoma and two cases of equine guttural pouch mycosis (23,26). The findings from the present case indicate that A. versicolor should be considered one of the causative agents of canine disseminated aspergillosis.…”

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confidence: 65%

Aspergillus versicolor, a New Causative Agent of Canine Disseminated Aspergillosis

et al. 2012

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Disseminated aspergillosis in dogs has been associated with Aspergillus terreus or A. deflectus infection. We report a case of disseminated A. versicolor infection presenting as diskospondylitis, osteomyelitis, and pyelonephritis. The diagnosis was made based on clinical, radiographic, and pathological findings. The etiologic agent was identified by fungal culture and internal transcribed spacer (ITS) ribosomal DNA (rDNA) sequencing. This is the first description of canine aspergillosis caused by A. versicolor. CASE REPORTA 31-kg, 2.5-year-old male castrated German shepherd dog was examined at the Texas A&M University Veterinary Medicine Teaching Hospital because of nonambulatory paraparesis, weight loss, and hyporexia for 3 months. At admission, the dog had a body temperature of 104.6°F, heart rate of 160 beats/min, respiratory rate of 80 breaths/min, and blood pressure of 173/99 mm Hg. Neurological examination revealed a hyperreflexive patellar reflex bilaterally. Motor function was absent in the right pelvic limb and questionable in the left. The patient had marked generalized muscle atrophy. A lateral radiograph of the cranial thorax revealed lysis and shortening of the first four sternebrae (Fig. 1A). The second and third sternebrae were most severely affected and had irregular margins with loss of their end plates. Lateral radiographs of the thoracic vertebral column showed lysis and shortening of the 9th (T9) and 10th (T10) thoracic vertebrae with loss of the end plates and spondylosis deformans ventrally (Fig. 1B). Narrowing of the intervertebral space, end plate sclerosis, and ventral spondylosis derformans were also found between the seventh and eighth thoracic vertebrae. The clinical diagnoses were diskospondylitis involving T9-T10, osteomyelitis of the sternum and left humerus, and T3-L3 myelopathy resulting in nonambulatory paraparesis. Suspected causes included disseminated aspergillosis, blastomycosis, coccidioidomycosis, bacterial infection, and neoplasia. Due to the poor prognosis, the dog was subsequently euthanized and a complete necropsy was performed.The major skeletal changes found at postmortem examination included marked bony proliferation of the cranial end of the sternum, extending from the first to the fourth sternebrae, with loss of the joint space between the second and third sternebrae ( Fig. 2A). A soft gray area of necrotizing osteomyelitis was in the center of the collapsed and fused sternebrae. In the thoracic vertebral column, there was loss of the intervertebral disk at T9-T10 with lysis of the associated vertebral end plates (Fig. 2B). The latter changes resulted in joint instability, overriding of the vertebral bodies, and spinal cord compression that was exacerbated with ventroflexion of the vertebral column. In the kidneys, there was dark red to purple mottling of the cortical region with dozens of white to tan areas throughout the cortex and medulla (Fig. 2C). The renal crests were ulcerated, and the pelvises were dilated and contained a small amount of cloudy fluid with ...

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Aspergillus versicolor, a New Causative Agent of Canine Disseminated Aspergillosis

et al. 2012

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“…Infections caused by Aspergillus species are more commonly seen in the respiratory tract of immunocompromised individuals or in those on prolonged antibiotic therapy . Although Aspergillus species are mentioned as possible causal organisms of mycetoma lesions, only one well‐documented case of Aspergillus ( A. versicolor) infection of the skin of horses has been reported . To the best of our knowledge, this is the first case report of a cutaneous mycetoma caused by Aspergillus terreus in a horse.…”

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confidence: 92%

Successful medical treatment of an Aspergillus terreus mycetoma of the nostril/lip in a 16‐year‐old Fjord pony gelding with pituitary pars intermedia dysfunction

Randleff-Rasmussen

Mosca

Knoerr³

et al. 2017

Veterinary Dermatology

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“…Although infection with S. apiospermum/P. boydii cannot be definitively diagnosed by cytologic or histopathologic examination, recognition of morphologic features of these fungi will guide specific diagnostic testing, such as fungal culture, PCR, and use of special stains 13,22,24 . Sabouraud agar with dextrose is frequently used when a dematiaceous, or pigmented, organism is suspected 10,11,25 .…”

Section: Discussionmentioning

confidence: 99%

Subconjunctival mycetoma caused by Scedosporium apiospermum infection in a horse

Berzina

Trumble

Novicki

et al. 2011

Veterinary Clinical Pathol

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An 11-year-old American Saddlebred gelding was presented for evaluation of a nonpainful subconjunctival mass involving the lateral canthus of the left eye. Other findings included a central corneal scar and a small central cataract of the lens in the left eye. Fine-needle aspiration of the mass was performed and cytologic examination revealed marked pyogranulomatous inflammation with intralesional fungal hyphae, consistent with mycetoma. The fungal structures were elongated and characterized by nonstaining walls; several bulbous yeast-like structures were also observed. The mycetoma was surgically removed and submitted for histopathologic examination and fungal culture. The histopathologic diagnosis was subconjunctival phaeohyphomycosis. Scedosporium apiospermum was identified based on macroscopic and microscopic features of the organism in culture. Scedosporium spp. have been reported as causes of mycetomatous and nonmycetomatous infections in both immunocompromised and immunocompetent people and animals. S. apiospermum and Pseudallescheria boydii, which is its teleomorphic counterpart, have been implicated as potentially emerging human and veterinary pathogens. Timely diagnosis is essential as the organism is often resistant to commonly used antifungal drugs. This report provides a detailed cytologic description of the organism and recent information on the taxonomy of this fungus and the diagnostic peculiarities of this particular infection.

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Subcutaneous Mycetoma-like Granuloma in a Horse Caused by Aspergillus Versicolor

Cited by 14 publications

References 6 publications

Aspergillus versicolor, a New Causative Agent of Canine Disseminated Aspergillosis

Aspergillus versicolor, a New Causative Agent of Canine Disseminated Aspergillosis

Successful medical treatment of an Aspergillus terreus mycetoma of the nostril/lip in a 16‐year‐old Fjord pony gelding with pituitary pars intermedia dysfunction

Subconjunctival mycetoma caused by Scedosporium apiospermum infection in a horse

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