Subcutaneous fat necrosis of the newborn

Rubin, Giulia; Spagnut, Giulia; Morandi, Francesco; Valerio, Enrico; Cutrone, Mario

doi:10.1002/ccr3.423

Cited by 26 publications

(35 citation statements)

References 8 publications

(19 reference statements)

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“…Recommendations in the literature commonly advise practitioners to screen for hypercalcemia until 6 months after the resolution of skin lesions, with a less common recommendation being to monitor for the first 6 weeks of life following a diagnosis of subcutaneous fat necrosis . However, little evidence supports these guidelines.…”

Section: Discussionmentioning

confidence: 99%

Subcutaneous fat necrosis of the newborn and associated hypercalcemia: A systematic review of the literature

Stefanko

Drolet

2018

Pediatric Dermatology

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Subcutaneous fat necrosis of the newborn is an uncommon disorder, and although usually benign, associated hypercalcemia can lead to complications such as failure to thrive and renal failure. Many sources suggest screening for hypercalcemia for 6 months following resolution of skin lesions, but little data are available to support this recommendation. This study examines existing published literature to better guide practitioners regarding screening evaluations of asymptomatic patients with subcutaneous fat necrosis. A systematic review of the literature was conducted using a PubMed English literature search. Data from case reports and case series were collected regarding the presence of hypercalcemia and associated complications, birth history, and age of onset/resolution of skin lesions and laboratory abnormalities. Approximately half (51%) of infants reported had hypercalcemia. Most (77%) developed detectable hypercalcemia within 30 days of skin lesion onset, and 95% developed detectable hypercalcemia within 60 days of skin lesion onset. Hypercalcemia was detected in only 4% of patients > 70 days following onset of skin lesions. Seventy-six percent had resolution of hypercalcemia within 4 weeks of detection. Hypercalcemia was more prevalent in full-term vs pre-term infants (P-value = 0.054), and higher birthweight was significantly associated with an increased risk of developing hypercalcemia (P-value = 0.022). Although gestational age trended toward significance, the only statistically significant clinical feature predicting the development of hypercalcemia was higher birthweight. Current recommendations for laboratory monitoring are not evidence-based, and this study provides interim data to guide practitioners until prospective, randomized controlled trials are conducted.

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Section: Discussionmentioning

confidence: 99%

Subcutaneous fat necrosis of the newborn and associated hypercalcemia: A systematic review of the literature

Stefanko

Drolet

2018

Pediatric Dermatology

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“…Con mayor frecuencia se desarrolla en RN a término (más de 37 semanas de edad gestacional) que han experimentado hipoxia u otro estrés perinatal. Entre otros factores de riesgo se encuentran: a) Neonatales: la hipotermia terapéutica para la asfixia 5 , aspiración de meconio, prolapso de cordón umbilical, sepsis, perforación intestinal y cardiopatías congénitas 6 ; b) Maternos: preeclampsia, diabetes gestacional, uso de sustancias (bloqueadores de los canales de calcio, cocaína), consumo y/o exposición pasiva de tabaco, incompatibilidad Rh materno-fetal 6,7 . En nuestro caso el paciente presentó una cardiopatía congénita tipo anomalía de Epstein, sin embargo con este tipo especifico de patología no se encontró asociación en la literatura.…”

Section: Discussionunclassified

Necrosis grasa del recién nacido

et al. 2020

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Introducción: Las paniculitis constituyen un grupo de enfermedades que afectan al tejido graso subcutáneo y se manifiestan clínicamente como nódulos. Su patogenia no es del todo clara, por lo general es asintomático. El diagnóstico confirmatorio es histológico.Objetivo: describir las características clínicas e histopatológicas de un caso de necrosis grasa, una forma especifica de paniculitis en el recién nacido (RN).Caso Clínico: RN femenino de 40 semanas, parto cesárea de urgencia por taquicardia fetal más meconio, APGAR 7-8-9. Requirió oxigeno y presión positiva por 5 min. Al quinto día de vida presentó aumento de volumen en tronco posterior, de coloración eritematosa - violácea, remitente a la palpación, no doloroso. Ecotomografría de piel y partes blandas informó aumento de la ecogenecidad del tejido celular subcutáneo y pérdida de definición de las celdillas adiposas de aproximadamente 42.3 x 9.7 x 20.1 mm, sin presencia de vascularización. Biopsia de piel: epidermis con acantosis irregular y ortoqueratosis en cestas; dermis papilar con infiltrado inflamatorio y dermis reticular y tejido adiposo con presencia de infiltrado linfohistocitiario con tendencia a la formación de nódulos, sin compromiso vascular, leves depósitos de colesterol; compatible con necrosis grasa del recién nacido (NGRN). Paciente tuvo regresión completa de la lesión a los tres meses de vida.Conclusiones: se describe un caso compatible clínica e histológicamente con NGRN; sin complicaciones durante su observación. Por lo general esta patología tiene buen pronóstico, con resolución espontánea, como en nuestro caso.

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“… 2 - 4 Acquired form of SCFN has been thought to be due to tissue necrosis and formation of granuloma secondary to poor tissue perfusion. 5 However, there are very few case reports of congenital SCFN in the literature.…”

Section: Discussionmentioning

confidence: 99%

“…However, a few serious sequelae have been reported, which include hypercalcemia, hypoglycemia, hypertriglyceridemia, and thrombocytopenia. 1 , 3 - 5 , 7 Hypercalcemia, in particular, has been shown to be commonly associated with SCFN. It is proposed that granulomatous tissue in SCFN has the capacity to activate vitamin D 3 as well as produce extrarenal calcitriol, both of which lead to hypercalcemia.…”

Section: Discussionmentioning

confidence: 99%

Newborn With Enlarged Erythematous Mass on Back: Case Report and Review of Medical Literature

Aye

Mahaseth

Rozzelle

et al. 2018

Global Pediatric Health

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Newborn skin nodules are usually benign and self-resolving skin condition. Differential diagnosis of such lesions include cysts, hemangioma, abscess, cellulitis, sclerema neonatorum, subcutaneous fat necrosis, neurofibromatosis, benign tumors, or malignant tumors such as rhabdomyosarcoma, infantile fibrosarcoma, or neuroblastoma. We report a case of congenital subcutaneous fat necrosis in a 7-day-old baby presenting with multiple erythematous mass on back.

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Subcutaneous fat necrosis of the newborn

Cited by 26 publications

References 8 publications

Subcutaneous fat necrosis of the newborn and associated hypercalcemia: A systematic review of the literature

Subcutaneous fat necrosis of the newborn and associated hypercalcemia: A systematic review of the literature

Necrosis grasa del recién nacido

Newborn With Enlarged Erythematous Mass on Back: Case Report and Review of Medical Literature

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