Subconjunctivally injected liposome encapsulated sirolimus and topical tacrolimus for the treatment of non-responsive keratoconjunctivitis sicca in the spontaneous dog model
Abstract:Objective: The aim of this study was to evaluate the therapeutic utility of sirolimus liposomes (prepared by two different techniques at two different doses) by subconjunctival injection, and tacrolimus ophthalmic solution at 0.03% in canine patients diagnosed with keratoconjunctivitis sicca (KCS) non-responsive to conventional treatment. Procedures: 20 privately owned pet dogs with clinically confirmed non-responsive KCS were randomized into 5 groups. Patients were administered with 0.15 ml of placebo or prod… Show more
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