Subclinical Organ Damage in White‐Coat Hypertension: The Possible Role of Cystatin C

Androulakis, Emmanuel; Papageorgiou, Nikolaos S.; Lioudaki, Eirini; Chatzistamatiou, E.; Zacharia, Effimia; Kallikazaros, Ioannis; Tousoulis, Dimitris

doi:10.1111/jch.12882

Cited by 13 publications

(8 citation statements)

References 49 publications

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“…In the study where non‐dipping was first defined, patients with a non‐dipping BP profile had a significantly higher stroke risk . The results of some subsequent studies support a link between non‐dipping status (elevated nocturnal BP) and a higher rate of cardiovascular events, but others failed to find such an association …”

Section: Resultsmentioning

confidence: 99%

Expert panel consensus recommendations for ambulatory blood pressure monitoring in Asia: The HOPE Asia Network

Kario

Shin

Chen³

et al. 2019

J of Clinical Hypertension

122

167

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Hypertension is an important public health issue because of its association with a number of significant diseases and adverse outcomes. However, there are important ethnic differences in the pathogenesis and cardio-/cerebrovascular consequences of hypertension. Given the large populations and rapidly aging demographic in Asian regions, optimal strategies to diagnose and manage hypertension are of high importance. Ambulatory | 1251 KARIO et Al.

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Section: Resultsmentioning

confidence: 99%

Expert panel consensus recommendations for ambulatory blood pressure monitoring in Asia: The HOPE Asia Network

Kario

Shin

Chen³

et al. 2019

J of Clinical Hypertension

122

167

View full text Add to dashboard Cite

show abstract

“… 7,8,16‐20 Most of the studies were conducted in Greece, whereas the other studies were conducted in Brazil, France, and Italy, being published between 2004 and 2019. Only three studies provided arterial stiffness details for all the hypertension phenotypes, 7,8 1 study compared only WCH with normotensives, 16 while one study compared WCH with both normotensives and sustained hypertensives 18 . The other two studies compared c‐f PWV in the MH and normotensive group and/or hypertensive group 17 .…”

Section: Resultsmentioning

confidence: 99%

Masked and white coat hypertension, the double trouble of large arteries: A systematic review and meta‐analysis

Antza

Vazakidis

Doundoulakis

et al. 2020

J of Clinical Hypertension

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Registration number (DOI): Available in https://osf.io/974gb/, https://doi.Abstract Arterial damage of large arteries, addressed as c-f PWV, is recognized as independent predictor for future cardiovascular disease. The aim of this study was to systematically investigate the association of the four hypertension phenotypes with carotidfemoral pulse wave velocity (c-f PWV), in untreated patients. PubMed and Cochrane Library were searched to identify studies comparing c-f PWV levels between normotensives, sustained hypertensives, white-coat hypertensives (WCH), and masked hypertensives (MH). Meta-analysis was performed to compare the difference c-f PWV levels between these groups. Newcastle-Ottawa quality assessment scale for crosssectional studies was used to assess study quality. MH and WCH patients had significantly increased c-f PWV values compared to the normotensive groups (d = 0.96 m/s, 95% CI: 0.49-1.42; I2 = 85%, P < .01 for MH and d = 0.85 m/s, 95% CI: 0.48-1.22; I2 = 89%, for WCH). Moreover, the sustained hypertensive population was found to have significantly increased values of c-f PWV compared to MH (d = −0.70 m/s, 95% CI: −0.87 to −0.54; I2 = 12%, P = .33) but not compared to WCH population (d = −0.75 m/s, 95% CI: −1.52-0.02; I 2 = 96%,). Finally, there was no significant difference between MH and WCH population (d = 0.06 m/s, 95% CI: −1.04 to 1.15; I 2 = 96%,). MH and WCH population may have increased values of c-f PWV compared to the normotensive group. These results demonstrate that these phenotypes are not clinically innocent, in the untreated population.

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“…Therefore, CysC has been long-regarded as a stable serum biomarker that reflects glomerular filtration function (7). Furthermore, it has been reported that elevated serum CysC is also related to the risk of hypertension (8,9), hypertension-induced myocardial hypertrophy (10)(11)(12), chronic and acute heart failure (13,14), hypertensive nephropathy (15,16), and cardiovascular disease morbidity and mortality (17)(18)(19)(20)(21)(22). Some researchers have found that excluding the influence of renal function, increased serum CysC levels still have diagnostic and prognostic value (17,18).…”

Section: Introductionmentioning

confidence: 99%

Pressure overload promotes cystatin C secretion of cardiomyocytes to regulate the MAPK signaling pathway and mediate cardiac hypertrophy

Shen

Zhang

et al. 2020

Ann Transl Med

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Background: This study aimed to compare serum cystatin C (CysC) levels between hypertensive and nonhypertensive patients, and to explore the correlation between serum CysC and left ventricular hypertrophy (LVH). We also investigated the effects of pressure overload on cardiac expression and secretion of CysC, and explored the direct effect of CysC on the hypertrophy of primary cardiomyocytes.Methods: Serum CysC was compared in patients with hypertension (634 patients) and those without hypertension (411 patients), and the correlation between serum CysC levels and LVH was explored. A transverse aortic constriction (TAC) mouse model and a mechanical stretch model of primary cardiomyocytes and fibroblasts were developed to compare cardiac expression and secretion of CysC under pressure overload.After intervention with exogenous CysC, we compared the cross-sectional area of primary cardiomyocytes, cardiac hypertrophy-associated gene expression, and phosphorylation of the MAPK signaling pathway.Results: In chronic kidney disease (CKD) stage 1 patients, serum CysC was higher in hypertensive patients independent of renal function. Serum CysC elevation was an independent predictor of LVH after correction for endogenous creatinine clearance rate (eCCr), left ventricular ejection fraction (LVEF), and NT-proBNP. Cardiac levels of CysC in TAC mice were elevated. CST3 gene expression was upregulated, and both intracellular and culture supernatant CysC levels increased after mechanical stretch of primary cardiomyocytes. After intervention with exogenous CysC, the cross-sectional area of primary cardiomyocytes increased, as well as the gene expression of Nppa, Nppb, and Myh7, and the phosphorylation of ERK, p38, and TAK1.Conclusions: Serum CysC levels were higher in hypertensive patients, and serum CysC elevation was an independent predictor of LVH after correction for eCCr. Pressure overload induced greater cardiomyocyte secretion of CysC. Exogenous CysC can enter cardiomyocytes, having a pro-hypertrophic effect on primary cardiomyocytes through regulation of the MAPK signaling pathways.

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Subclinical Organ Damage in White‐Coat Hypertension: The Possible Role of Cystatin C

Cited by 13 publications

References 49 publications

Expert panel consensus recommendations for ambulatory blood pressure monitoring in Asia: The HOPE Asia Network

Expert panel consensus recommendations for ambulatory blood pressure monitoring in Asia: The HOPE Asia Network

Masked and white coat hypertension, the double trouble of large arteries: A systematic review and meta‐analysis

Pressure overload promotes cystatin C secretion of cardiomyocytes to regulate the MAPK signaling pathway and mediate cardiac hypertrophy

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