Subclinical Hypothyroidism Represents Visceral Adipose Indices, Especially in Women With Cardiovascular Risk

Abstract

Background To evaluate regional-specific cardiovascular fat tissue [pericardial fat (PCF) and thoracic peri-aortic fat (TAT)] and non-invasive visceral adipose indices [body shape index (ABSI), and body roundness index (BRI), Chinese visceral adiposity index (CVAI)] in patients with subclinical hypothyroidism (SCH) as compared to a control population and relative to variations in cardiovascular risk. Methods 125 Taiwanese patients recently diagnosed with SCH (age: 52.9±10.16 years, 41.6% female) and 1519 healthy volunteers (age: 49.54±9.77 years, 29.0% female) were evaluated for this study. All participants underwent PCF and TAT assessment using an multidetector computed tomography scanner (MDCT), ABSI, BRI, and CVAI evaluation using mathematical formula. Cardiovascular risk was classified by Framingham risk score (FRS). Results Multivariable logistic regression models showed that the independent association of TAT and BRI with SCH were stronger in women than men. The adjusted model associations [odds ratio (OR), 95% confidence interval (CI)] with SCH for TAT and BRI in women were 2.61(1.03-6.97) and 2.04(1.07-3.92). The incidences of TAT and BRI 3 rd tertile were also higher in women with SCH (SCH vs EU, TAT 3 rd tertile, 9 (17.3%) vs 35 (7.9%), P=0.04; BRI 3 rd tertile, 22 (42.3%) vs 111(25.2%), P=0.01). In addition to BRI and TAT, there were higher risk of CVAI in SCH with intermediate/high FRS, especially in women [OR (95% CI): TAT: 4.01(1.01-6.640; BRI: 6.91 (1.03-10.23); CVAI: 7.81 (1.01-12.03)]. Conclusion Our findings show that patients with SCH have significantly greater TAT, BRI and CVAI values than control groups, especially in females (with different FRS).

Chinese Visceral Adiposity Index Is More Closely Associated With Hypertension and Prehypertension Than Traditional Adiposity Indices in Chinese Population: Results From the REACTION Study

“…In comparison to Caucasians, Asians exhibit higher levels of body adiposity at lower BMI levels (14,16), and are more likely to accumulate visceral fat (14,17).Xia et al established the Chinese visceral adiposity index (CVAI) using multivariate linear regression analysis in 485 people recruited from Xiamen, China in 2016, and validated it in 6495 subjects recruited from Shanghai, China (14). CVAI has been confirmed more associated with diabetes (15,18), diabetes complications (19), atherosclerotic disease (20,21), polycystic ovary syndrome (22), and subclinical hypothyroidism (23) than other adiposity indices in the Chinese population, while other studies have found a significant association between CVAI and diabetes in the Japanese population (24). Studies on the relationship between CVAI and hypertension are limited (25), and the relationship between CVAI and prehypertension has not been investigated.…”

Factors affecting blood pressure in patients with arterial hypertension and subclinical hypothyroidism

“…Moreover, patients with a combined course of HTN and SH tend to have anemia and liver abnormalities, which makes the effect of hemoglobin and AP levels more noticeable in this category of patients. In addition, gender in patients with SH is associated with a number of factors that may affect blood pressure, that are a high risk of developing NAFLD in men [38], worse noninvasive visceral fat indices in women [39], higher incidence of metabolic syndrome and its components [40].…”

A novel index, Chinese visceral adiposity index is closely associated with urinary albumin‐creatinine ratio in Chinese community adults, especially in hypertensive or hyperglycemic population: Results from the REACTION study

“… 19 A total of 485 participants from Xiamen, China received abdominal CT for visceral adiposity area, then CVAI was established utilizing multivariate linear regression analyses and was further verified in 6495 participants from Shanghai, China that it was highly correlated with visceral adipose and it was more valuable compared to BMI and WC in the assessment of metabolic risks. 19 Besides, CVAI has been reported to be more significantly related to diabetes, 20 diabetes complications, 21 atherosclerosis, 22 , 23 polycystic ovary syndrome, 24 hypothyroidism, 25 and hypertension 26 than other obesity indices among the Chinese population, and one study has discovered a close relation between CVAI and diabetes among the Japanese population. 27 However, the research on the relationship between CVAI and UACR is limited.…”