Subclinical Hypothyroidism and Left Ventricular Mechanics: A Three-Dimensional Speckle Tracking Study

Tadić, Marijana; Ilić, Sanja; Kostić, Nada; Čaparević, Zorica; Ćelić, Vera

doi:10.1210/jc.2013-3107

Cited by 32 publications

(35 citation statements)

References 27 publications

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“…In this study, the difference in EF of 3.4% was statistically significant. However, TDI analyses in other studies [13,22,23] showed disruption in LV systolic function in patients with ScH.…”

Section: Discussionmentioning

confidence: 77%

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Influence of the Subclinical Hypothyroidism on the Left Ventricular Systolic and Diastolic Function (pilot study)

Nakova¹

2014

Thyroid Disorders Ther

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Section: Discussionmentioning

confidence: 77%

“…Identical as our results, Sunbul et al [15] found longitudinal myocardial dysfunction in 23 patients with ScH and their improvement after thyroid replacement therapy. Ilic et al [20] and Tadic et al [23] also showed a decrease of GLS in patients with ScH.…”

Section: Discussionmentioning

confidence: 94%

Influence of the Subclinical Hypothyroidism on the Left Ventricular Systolic and Diastolic Function (pilot study)

Nakova¹

2014

Thyroid Disorders Ther

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“…These results are also supported by a study that used 3D echocardiography. Indeed, Tadic et al showed that subclinical hypothyroidism affects LV deformation and that 1 year of levothyroxine treatment improved LV mechanics …”

Section: Discussionmentioning

confidence: 99%

Effects of short‐term levothyroxine therapy on myocardial injuries in patients with severe overt hypothyroidism: Evidence from a cardiac MRI Study

Gao

Chen

Liu

et al. 2017

Magnetic Resonance Imaging

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“…This point is where TH appear to have a role in the physiopathology of DD, since low TH levels increase collagen synthesis and deposit in myocardium and decrease collagen metabolism in several ways [27][28][29][30] . Data from studies in non-renal patients with thyroid disorders have shown the relationship of low TH with decreased myocardial motility and increased collagen content [31,32] . In a cross-sectional study in patients with heart failure with preserved ejection fraction (>50%), T3 was found significantly reduced [33] .…”

Section: Discussionmentioning

confidence: 99%

High Prevalence of Diastolic Dysfunction in Incident Patients on Peritoneal Dialysis: Association with Low Thyroid Hormones

Sánchez

Paniagua²,

Prado³

et al. 2016

Nephron

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Background/Aims: Diastolic dysfunction (DD) and low levels of thyroid hormones (TH) are frequent found in chronic kidney disease; both are associated with all-cause and cardiovascular mortality. However, a link between them has not yet been established. The aim of this study was to analyze DD as a surrogate marker of fibrosis and its association with TH in incident patients on peritoneal dialysis (PD). Methods: A cross-sectional study with 183 incident patients on PD with preserved ejection fraction was performed. Clinical and demographic data were registered. Serum total and free (t/f) triiodothyronine (T3), thyroxin (T4), and thyroid stimulating hormone levels were determined by RIA kits, albumin and high-sensitivity C-reactive protein by conventional assays. Transthoracic 2D echocardiogram was performed for evaluation of left ventricular (LV) mass and ejection fraction. DD was evaluated using pulsed-wave tissue Doppler imaging. Results: Patients were 43 ± 12, 42% with diabetes mellitus (DM). Some degree of DD was found in 62% of patients; 18% had grade I DD, 8% grade II DD and 36% grade III DD. Patients with grade III DD were more likely to have diabetes, older, high LV mass and low serum albumin, t/fT3 and tT4 levels. In logistic multivariate regression analysis, it was found that diabetes (B = -0.86, 95% CI 0.182-0.992, p < 0.05), hypertension (B = -0.95, 95% CI 0.184-0.817, p = 0.01) and tT3 (B = -1.94, 95% CI 0.023-0.876, p < 0.05) were associated with grade III DD. Conclusions: High prevalence of grade III DD was found in incident patients on PD. In addition to DM and hypertension, tT3 was found to be an independent risk factor for grade III DD and more studies are needed to understand the reasons as to why this association is present.

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Subclinical Hypothyroidism and Left Ventricular Mechanics: A Three-Dimensional Speckle Tracking Study

Abstract: SHT significantly affects LV deformation assessed by 2DE and 3DE speckle tracking. The improvement of LV mechanics after 1 year of levothyroxine treatment is significant but incomplete.

Cited by 32 publications

References 27 publications

Influence of the Subclinical Hypothyroidism on the Left Ventricular Systolic and Diastolic Function (pilot study)

Influence of the Subclinical Hypothyroidism on the Left Ventricular Systolic and Diastolic Function (pilot study)

Effects of short‐term levothyroxine therapy on myocardial injuries in patients with severe overt hypothyroidism: Evidence from a cardiac MRI Study

High Prevalence of Diastolic Dysfunction in Incident Patients on Peritoneal Dialysis: Association with Low Thyroid Hormones

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