Subclinical carotid atherosclerosis and cardiovascular risk factors in HIV-infected patients

Kwiatkowska, Wiesława; Knysz, Brygida; Drelichowska-Durawa, Justyna; Czarnecki, M; Gąsiorowski, Jacek; Biłyk, Ewa; Karczewski, Maciej; Witkiewicz, Wojciech

doi:10.5604/17322693.967075

Cited by 15 publications

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“…Their study involved 2018 subjects, whereas ours was 393. However, a report by Kwiatkowska et al [20] showed a prevalence of 6.8% in a study involving 72 subjects in Poland [20], a prevalence similar to our finding. In a related study in HAART-treated subjects [21], the prevalence of underweight 2.0% was lower than that obtained in our study.…”

Section: Discussionsupporting

confidence: 92%

BMI and Risk Factors of Underweight and Obesity in HIV Subjects in Eastern Nigeria

Anyabolu¹

2016

WJA

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Background and Objectives: Human immunodeficiency virus infection (HIV) is a global healthcare problem. Progression of HIV infection is commonly associated with decreasing weight. In the early phases of HIV infection, factors associated with weight changes are not completely known. This study evaluated the body mass index (BMI) and its potential risk factors in drug-naïve HIV subjects in Owerri, Eastern Nigeria. Methodology: This was a cross-sectional study of HIV subjects. BMI was determined. Relevant investigations were performed. Potential risk factors of BMI were analyzed at different BMI categories. Association of variables with BMI and the strength of variables to predict BMI, underweight and obesity were determined. Results: The mean BMI of the HIV subjects was 26.2 ± 5.4 kg/m 2. Underweight was present in 24 (6.1%), overweight in 150 (38.4%) and obesity in 84 (21.5%) of the HIV subjects. High spot urine creatinine (SUCr), high 24-hour urine osmolality (24HUOsm), high serum cholesterol and high hemoglobin predicted BMI in HIV subjects. Low 24HUOsm predicted under weight, whereas low 24-hour urine protein (24 HUP) and high 24HUOsm predicted obesity in HIV subjects. Conclusion: The prevalence of underweight was low (6.1%), overweight high (38.4%) and obesity high (21.5%) in HIV subjects. High SUCr, high 24HUOsm, high serum cholesterol and high hemoglobin were predictors of BMI in HIV subjects. Low 24HUOsm was a predictor of underweight, while low 24HUP and high 24HUOsm were predictors of obesity in HIV subjects. Abnormalities of serum lipids, renal function, and anemia were common in HIV subjects who were underweight and in those obese. Underweight HIV subjects should be evaluated at the early stages for dyslipidemia, renal damage and anemia.

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Section: Discussionsupporting

confidence: 92%

BMI and Risk Factors of Underweight and Obesity in HIV Subjects in Eastern Nigeria

Anyabolu¹

2016

WJA

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“…Our findings, along with results from previous studies [3, 6, 10–13], raise questions about what may be an evolving relationship between lipid abnormalities and atherosclerosis across the course of HIV infection. An important study limitation is lack of information about duration of HIV infection.…”

Section: Discussionsupporting

confidence: 53%

Association of subclinical atherosclerosis with lipid levels amongst antiretroviral-treated and untreated HIV-infected women in the Women's Interagency HIV study

Parrinello¹,

Landay²,

Hodis³

et al. 2012

Atherosclerosis

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Objective We examined serum lipids in association with carotid artery intima-media thickness (CIMT) in HIV-infected and HIV-uninfected women. Methods In 2003–4, among 1827 Women’s Interagency HIV Study participants, we measured CIMT and lipids (high-density lipoprotein cholesterol [HDL-c], low-density lipoprotein cholesterol [LDL-c], total cholesterol [TC], non-HDL-c). A subset of 520 treated HIV-infected women had pre-1997 lipid measures. We used multivariable linear regression to examine associations between lipids and CIMT. Results In HIV-uninfected women, higher TC, LDL-c and non-HDL-c were associated with increased CIMT. Among HIV-infected women, associations of lipids with CIMT were observed in treated but not untreated women. Among the HIV-infected women treated in 2003–4, CIMT was associated both with lipids measured a decade earlier in infection, and with late lipid measurements. Conclusion Among HIV-infected women, hyperlipidemia is most strongly associated with subclinical atherosclerosis in treated women. Among treated women, the association appeared strongest early in the disease course.

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“…Metabolic syndrome was recognized according to the International Diabetes Federation (IDF) criteria with typical European waist circumference values [10] . Carotid intima-media thickness (cIMT) was measured – the cIMT measurement methods were presented in the previous paper [11] . Lipid disorders were assessed based on the NCEP ATP III guidelines; borderline levels of total cholesterol and triglycerides were considered abnormal [9] .…”

Section: Methodsmentioning

confidence: 99%

Peripheral Arterial Disease and Ankle-Brachial Index Abnormalites in Young and Middle-Aged HIV-Positive Patients in Lower Silesia, Poland

et al. 2014

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BackgroundPeripheral arterial disease (PAD) is a clinical manifestation of atherosclerosis and mainly refers to elderly patients, having a negative impact on their functionality and quality of life. The findings of previous studies in HIV-infected patients have shown that cardiovascular risk is higher and PAD occurs more frequently than in the general population. There are also contradictory observations. Much less is known about the ankle-brachial index (ABI) value in asymptomatic HIV-infected patients. The aim of this study was to evaluate the prevalence of PAD and ankle-brachial index abnormalities as well as to determine risk factors related to the disease in a group of Polish HIV–positive patients.Methods and FindingsOne hundred and eleven young to middle aged HIV–positive subjects and 40 noninfected subjects were enrolled into the study. Resting ABI measurements were performed and cardiovascular risk was analysed as well. Subgroups were created according to the ABI values: low (PAD), borderline, normal, high and altered ABI. Symptomatic PAD was observed in 2 HIV–positive patients, asymptomatic PAD was not diagnosed. The ABI value is lower and more varied, in 22.5% of the study group altered ABI values were found. Six subjects demonstrated borderline ABI, and 15 high ABI, including >1.4. In the control group no low or very high values were reported. A relation between low ABI and cardiovascular family history and between altered ABI and high–density–lipoprotein cholesterol (HDL–C) level was demonstrated.ConclusionsIn young and middle–aged HIV–positive patients, symptomatic PAD prevalence is comparable to that observed in the overall population. Among asymptomatic patients PAD is not reported. The ABI value in HIV–positive patients is more varied compared to the HIV–negative subjects; the altered ABI shows a strong relation with low HDL–C levels and metabolic syndrome.

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Subclinical carotid atherosclerosis and cardiovascular risk factors in HIV-infected patients

Cited by 15 publications

References 0 publications

BMI and Risk Factors of Underweight and Obesity in HIV Subjects in Eastern Nigeria

BMI and Risk Factors of Underweight and Obesity in HIV Subjects in Eastern Nigeria

Association of subclinical atherosclerosis with lipid levels amongst antiretroviral-treated and untreated HIV-infected women in the Women's Interagency HIV study

Peripheral Arterial Disease and Ankle-Brachial Index Abnormalites in Young and Middle-Aged HIV-Positive Patients in Lower Silesia, Poland

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