Subclinical atherosclerosis in patients with chronic psoriasis: a potential association

El-Mongy, Shaymaa; Fathy, Heba; Abdelaziz, Ayman Ahmed; Omran, Elham; George, S.; Neseem, Nanis O.; Elnour, Noha Khogaly Mohammed

doi:10.1111/j.1468-3083.2009.03481.x

Cited by 94 publications

(117 citation statements)

References 30 publications

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“…Recent study by Kimhi et al (27) showed that psoriatic arthritis patients had significantly higher CIMT compared with controls (0.76 ± 0.11 versus 0.64 ± 0.27, P < 0.00001) which was similar to results given by Gonzalez et al and Mongi et al (28,29). In our current study, we have observed a similar trend with significantly higher CIMT (P < 0.001).…”

Section: Discussionsupporting

confidence: 82%

Association of Carotid Intima-Media Thickness With Leptin and Apolipoprotein B/Apolipoprotein a-I Ratio Reveals Imminent Predictors of Subclinical Atherosclerosis in Psoriasis Patients

Asha

Sharma

Singal

et al. 2014

Acta Med. (Hradec Kralove, Czech Repub.)

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Summary: Psoriasis patients are often susceptible to cardiovascular diseases (CVD), including atherosclerosis. Traditional markers (biochemical and inflammatory) and diagnostic tools could detect occlusive but not subclinical atherosclerosis. Carotid intima-media thickness (CIMT), has recently been recognised as a non invasive diagnostic tool for identification of premature atherosclerosis. Therefore we evaluated 80 psoriasis patients and 80 age sex matched healthy controls for serum leptin levels and apolipoprotein B/apolipoprotein A-I ratio (apoB/apoA-I ratio) in relation with CIMT of carotid artery. Carotid intima-media thickness and carotid plaques were simultaneously measured by carotid sonography. Serum concentration of leptin and apolipoprotein were measured using enzyme-linked immuno sorbent assay (ELISA) and nephelometry respectively. Raised CIMT correlated to age of onset of the disease, serum leptin and apoB/apoA-I ratio in psoriasis patients. Taking into account, values that were above the 75 percentile of the three markers (leptin, apoB/apoA-I ratio and CIMT) the odds ratio was 4.26 (2.06-8.80 CI). Leptin and apoB/apoA-I ratio showed significant cumulative association with CIMT. Results of predictive analysis supports measurement of CIMT along with estimation of serum leptin and apoB/apoA-I ratio for prediction of premature atherosclerosis in psoriasis patients.

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Section: Discussionsupporting

confidence: 82%

Association of Carotid Intima-Media Thickness With Leptin and Apolipoprotein B/Apolipoprotein a-I Ratio Reveals Imminent Predictors of Subclinical Atherosclerosis in Psoriasis Patients

Asha

Sharma

Singal

et al. 2014

Acta Med. (Hradec Kralove, Czech Repub.)

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“…4,8,30,31 The shared inflammatory pathways with common proinflammatory mediators (TNF-alfa, interleukin-1, interleukin-6) might be responsible for simultaneously provoking skin symptoms and inducing chronic endothelial dysfunction and later atherosclerotic plaque development. 27,32,33 Endothelial dysfunction and artery wall inflammation involve infiltration of Th1 helper cells, neutrophils, and monocytes. TNF-alfa enhances adhesion molecule (eg, intercellular adhesion molecule 1 [ICAM-1]) expression on the endothelium, thereby supporting extravasation of inflammatory cells into the vessel wall.…”

Section: Discussionmentioning

confidence: 99%

Impact of effective tumor necrosis factor-alfa inhibitor treatment on arterial intima-media thickness in psoriasis: Results of a pilot study

Jókai

Szakonyi

Kontár

et al. 2013

Journal of the American Academy of Dermatology

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“…Although common results from previous studies point out an increase in CIMT in psoriatic patients, there are also conflicting results in terms of the factors leading to increased CIMT values. In a study by El-Mongy et al, 29 CIMT was found to be increased in patients with psoriasis without any accompanying risk factors for atherosclerosis. CIMT is biologically and genetically distinct phenotypes of early atherosclerosis.…”

Section: Discussionmentioning

confidence: 96%

Carotid intima–media thickness, nonalcoholic fatty liver disease, and hemoglobin A1c are independently associated with the severity of psoriasis

İnci

Öztürk

İnci

et al. 2016

Dermatologica Sinica

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Keywords: atherosclerosis cardiovascular risk carotid artery intimaemedia thickness nonalcoholic fatty liver disease psoriasis a b s t r a c t Background: Systemic inflammation plays an important role in the pathogenesis of atherosclerosis in psoriasis patients. Carotid artery intimaemedia thickness (CIMT) and nonalcoholic fatty liver disease (NAFLD) are accepted important markers for subclinical atherosclerosis and cardiovascular risk prediction.Objectives: The aim of this study was to evaluate the potential association between subclinical atherosclerosis and chronic plaque psoriasis without traditional cardiovascular risk factors. Methods: Sixty consecutive patients with chronic plaque psoriasis (patient group) attending our dermatology outpatient clinic and 60 age-and sex-matched healthy controls (control group) were included in this study. Demographic and biochemical data, and Psoriasis Area and Severity Index (PASI) score of the psoriasis group were recorded. CIMT and NAFLD values were compared. Results: Patients with psoriasis had significantly higher systolic and diastolic blood pressure, fasting levels of glucose, and hemoglobin A1c (HbA1c) compared with controls. Patients with psoriasis had greater CIMT and NAFLD values than matched controls. PASI score was significantly positively correlated with systolic and diastolic blood pressure, body mass index, waist circumference, psoriasis duration, HbA1c, the presence of NAFLD, moderateesevere NAFLD, and CIMT in psoriatic patients. In multivariate linear regression analysis, HbA1c, moderateesevere NAFLD, and CIMT were significantly and independently associated with PASI score, and CIMT showed the most significant association with PASI score. Conclusion: Our data suggest a need for aggressive treatment of the inflammatory process in psoriatic patients as well as better monitoring of nontraditional atherosclerotic risk factors to reduce cardiovascular mortality/morbidity and liver diseases. Abdominal and carotid ultrasonography appear to be useful, simple, and noninvasive examinations to investigate the presence of subclinical atherosclerosis even in psoriatic patients who seem to be otherwise healthy.

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Subclinical atherosclerosis in patients with chronic psoriasis: a potential association

Cited by 94 publications

References 30 publications

Association of Carotid Intima-Media Thickness With Leptin and Apolipoprotein B/Apolipoprotein a-I Ratio Reveals Imminent Predictors of Subclinical Atherosclerosis in Psoriasis Patients

Association of Carotid Intima-Media Thickness With Leptin and Apolipoprotein B/Apolipoprotein a-I Ratio Reveals Imminent Predictors of Subclinical Atherosclerosis in Psoriasis Patients

Impact of effective tumor necrosis factor-alfa inhibitor treatment on arterial intima-media thickness in psoriasis: Results of a pilot study

Carotid intima–media thickness, nonalcoholic fatty liver disease, and hemoglobin A1c are independently associated with the severity of psoriasis

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