Subchronic Toxicity of Cupric Sulfate Administered in Drinking Water and Feed to Rats and Mice

Hébert, Charles; Elwell, Michael R.; Travlos, Gregory S.; Fitz, Chad; Bucher, John R.

doi:10.1006/faat.1993.1122

Cited by 74 publications

(26 citation statements)

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“…Copper sulfate at high exposure levels is a hepatic and renal toxicant and an inducer of anemia in rodents, with rats more sensitive than mice following subchronic exposure [10]. Acute copper poisoning has been well described in goats and sheep [7,14].…”

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confidence: 99%

Acute and Subacute Toxicity of Copper Sulfate Pentahydrate (CuSO45 H2O) in the Guppy (Poecilia reticulata)

Park

Heo

2009

J. Vet. Med. Sci.

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ABSTRACT. Chemicals are used for treatment of aquatic diseases, but there is little data available about copper sulfate in small ornamental fish. The aim of the present study was to determine the TLm 24h and evaluate the toxicity of copper sulfate in the guppy (Poecilia reticulata). The fish were subjected to an acute toxicity test for 24 hr, and the results showed a TLm 24h value of 1.17 ppm. Severe hyperplasia and exfoliation of the epithelial cells of gill lamellae and obstruction of the internal cavities of renal tubules with necrotized renal epithelial cells sloughed from the basement membrane were observed. However, no significant changes, except for mild curling of gill lamellae, were found in a subacute toxicity test in which fish were exposed to 1/10 of the TLm 24h value for 1 week. Therefore, use of less than 0.12 ppm of copper sulfate may be recommended as a therapeutic level.

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confidence: 99%

Acute and Subacute Toxicity of Copper Sulfate Pentahydrate (CuSO45 H2O) in the Guppy (Poecilia reticulata)

Park

Heo

2009

J. Vet. Med. Sci.

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“…Nutritional studies of chronic copper overload in both mice and rats have shown copper-induced liver damage in these animals (1,19,38). In addition, WD, a human genetic disorder of copper overload, is characterized by a gradual hepatic accumulation of copper that eventually results in liver cirrhosis (7).…”

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Gene expression profiling in chronic copper overload reveals upregulation ofPrnpandApp

Armendariz

González

Loguinov

et al. 2004

Physiological Genomics

102

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The level at which copper becomes toxic is not clear. Several studies have indicated that copper causes oxidative stress; however, most have tested very high levels of copper exposure. We currently have only a limited understanding of the protective systems that operate in cells chronically exposed to copper. Additionally, the limits of homeostatic regulation are not known, making it difficult to define the milder effects of copper excess. Furthermore, a robust assay to facilitate the diagnosis of copper excess and to distinguish mild, moderate, and severe copper overload is needed. To address these issues, we have investigated the effects on steady-state gene expression of chronic copper overload in a cell culture model system using cDNA microarrays. For this study we utilized cells from genetic models of copper overload: fibroblast cells from two mouse mutants, C57BL/6- Atp7aMobr and C57BL/6- Atp7aModap. These cell lines accumulate copper to abnormally high levels in normal culture media due to a defect in copper export from the cell. We identified 12 differentially expressed genes in common using our outlier identification methods. Surprisingly, our results show no evidence of oxidative stress in the copper-loaded cells. In addition, candidate components perhaps responsible for a copper-specific homeostatic response are identified. The genes that encode for the prion protein and the amyloid-β precursor protein, two known copper-binding proteins, are upregulated in both cell lines.

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“…This study revealed a higher sensitivity of rats to copper(II) sulfate pentahydrate compared with mice. In male and female rats, the NOAEL for copper was 16 mg/kg body weight for the effects on the forestomach, 16 and 34 mg/kg body weight, respectively, for liver damage, and 16 and 9 mg/kg body weight per day, respectively, for renal toxicity (Hébert 1993. A NOAEL for copper of 9 and 16 mg/kg body weight per day can be derived from this study for systemic effects in male and female rats, respectively.…”

Section: Ingestionmentioning

confidence: 99%

Copper and its inorganic compounds [MAK Value Documentation, 2006]

2012

The MAK‐Collection for Occupational Health and Safety

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Published in the series MAK Value Documentations , Vol. 22 (2006) The article contains sections titled: Toxic Effects and Mode of Action Mechanism of Action Toxicokinetics and Metabolism Effects in Humans Single exposures Repeated exposures Local effects on skin and mucous membranes Allergenic effects Reproductive toxicity Carcinogenicity Animal experiments and in vitro studies Acute toxicity Subacute, subchronic and chronic toxicity Local effects on skin and mucous membranes Allergenic effects Reproductive toxicity Genotoxicity Carcinogenicity Other effects Manifesto (MAK value/classification)

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Subchronic Toxicity of Cupric Sulfate Administered in Drinking Water and Feed to Rats and Mice

Cited by 74 publications

References 0 publications

Acute and Subacute Toxicity of Copper Sulfate Pentahydrate (CuSO45 H2O) in the Guppy (Poecilia reticulata)

Acute and Subacute Toxicity of Copper Sulfate Pentahydrate (CuSO45 H2O) in the Guppy (Poecilia reticulata)

Gene expression profiling in chronic copper overload reveals upregulation ofPrnpandApp

Copper and its inorganic compounds [MAK Value Documentation, 2006]

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