Copper and its inorganic compounds [MAK Value Documentation, 2006]

Abstract

Published in the series MAK Value Documentations , Vol. 22 (2006) The article contains sections titled: Toxic Effects and Mode of Action Mechanism of Action Toxicokinetics and Metabolism Effects in Humans Single exposures Repeated exposures Local effects on skin and mucous membranes Allergenic effects Reproductive toxicity Carcinogenicity Animal experiments and in vitro studies Acute toxicity Subacute, subchronic and chronic toxicity Local effects on skin and mucous membranes Allergenic effects Reproductive toxicity Genotoxicity Carcinogenicity Other effects Manifesto (MAK value/classification)

Copper ions are novel therapeutic agents for uterine leiomyosarcoma

“…The toxicity of CuSO 4 in vivo has been comprehensively investigated in previous studies, and its median lethal dose in mice, 3 days after injection, is 29.5 mg/ kg. 44 Another study reported that intraperitoneal injection of CuSO 4 in single doses of 6.6, 13.2, or 19.9 mg/kg body weight produced no micronucleus induction in male CBA mice. 45 Similar results were reported in another study that investigated the bone marrow of the animals treated with intraperitoneal injection of 6.6 mg/kg CuSO 4 after 24 and 48 hours.…”