Subchronic toxicity and genotoxicity studies of Hericium erinaceus β-glucan extract preparation

Chen, S.N.; Chang, Chen; Yang, M.F.; Chen, S.; Soni, Madhu G.; Mahadevan, B.

doi:10.1016/j.crtox.2022.100068

Cited by 5 publications

(4 citation statements)

References 38 publications

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“…Mushrooms are not only significant for their traditional edible value, but also for their medicinal value [ 51 ]. Mushrooms are known also as functional foods, mainly for their bioactive compounds that can have various beneficial impacts on human health [ 52 ].…”

Section: Resultsmentioning

confidence: 99%

Analysis of Biochemical and Genetic Variability of Pleurotus ostreatus Based on the β-Glucans and CDDP Markers

Golian

Chlebová

Žiarovská

et al. 2022

JoF

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Oyster mushroom (Pleurotus ostreatus) is still one of the most cultivated edible and medicinal mushrooms. Despite its frequent cultivation around the world, there is currently just a little information available on the variability of strains in terms of the content of β-glucans in them. This work presents an extensive study of 60 strains in terms of the content of α-glucans and β-glucans in their caps and stipes. The authenticity of the production strains based on an analysis of the variability of their genome by CDDP (Conserved DNA-derived polymorphism) markers was confirmed, whereas identical CDDP profiles were identified between samples 45, 89, 95, and 96. Genetic variability of the analyzed production strains showed a high polymorphism and effective discriminative power of the used marking technique. Medium positive correlations were found among the CDDP profiles and β-glucan content in the group of strains that generated the same CDDP profiles, and low negative correlation was found among these profiles in the group of low β-glucan content strains. For the determination of glucans content, Mushroom and Yeast analytical enzymatic kit (Megazyme, Bray, Co. Wicklow, Ireland) were used. The results clearly showed that the stipe contains on average 33% more β-glucans than the cap. The minimum detected β-glucan content in the stipe was in strain no. 72, specifically 22%, and the maximum in strain no. 43, specifically 56%, which after the conversion represents a difference of 155%. From the point of view of β-glucan content, the stated strain no. 43 appears to be very suitable for the commercial production of β-glucans under certain conditions.

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Section: Resultsmentioning

confidence: 99%

Analysis of Biochemical and Genetic Variability of Pleurotus ostreatus Based on the β-Glucans and CDDP Markers

Golian

Chlebová

Žiarovská

et al. 2022

JoF

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“…The results observed no treatment-related significant toxicological effects in various parameters, including clinical observations, ophthalmic examinations, body weight gains, feed consumption, organ weights, hematology, serum chemistry, urinalysis, and terminal necropsy findings. Based on the sub-chronic study, the No Observed Adverse Effect Level (NOAEL) for H. erinaceus β-glucan extract preparation was determined as 2000 mg/kg body weight per day, which was the highest dose tested [ 21 ]. Similarly, Li et al demonstrated that the consumption of standardized erinacine A-enriched H. erinaceus mycelium poses no genotoxic hazards to individuals, as evidenced by in vitro mutagenicity tests and in vivo assays (mouse erythrocyte micronucleus assay) [ 22 ].…”

Section: Toxicology Studiesmentioning

confidence: 99%

Unveiling the Chemical Composition and Biofunctionality of Hericium spp. Fungi: A Comprehensive Overview

Kostanda,

Musa,

Pereman

2024

IJMS

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In recent years, research on mushrooms belonging to the Hericium genus has attracted considerable attention due to their unique appearance and well-known medicinal properties. These mushrooms are abundant in bioactive chemicals like polysaccharides, hericenones, erinacines, hericerins, resorcinols, steroids, mono- and diterpenes, and corallocins, alongside essential nutrients. These compounds demonstrate beneficial bioactivities which are related to various physiological systems of the body, including the digestive, immune, and nervous systems. Extensive research has been conducted on the isolation and identification of numerous bioactive chemicals, and both in vitro and in vivo studies have confirmed their antimicrobial, antioxidant, immunomodulatory, antidiabetic, anticholesterolemic, anticancer, and neuroprotective properties. Therefore, this review aims to provide a comprehensive summary of the latest scientific literature on the chemical composition and secondary metabolites profile of Hericium spp. through an introduction to their chemical characteristics, speculated biosynthesis pathways for key chemical families, potential toxicological aspects, and a detailed description of the recent updates regarding the bioactivity of these metabolites.

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“…No toxicity, morbidity, or mortality signs were observed [146]. Chen et al (2022) also conducted subchronic toxicity and genotoxicity studies of H. erinaceus β-glucan extract preparation [147]. The study was conducted in Sprague-Dawley rats, and based on the results, the No Observed Adverse Effect Level (NOAEL) for the β-glucan extract preparation from H. erinaceus was determined to be 2000 mg/kg body weight/day, which was the highest tested dose.…”

Section: Toxicology Studiesmentioning

confidence: 99%

Neurotrophic and Neuroprotective Effects of Hericium erinaceus

Szućko-Kociuba,

Trzeciak-Ryczek,

Kupnicka

et al. 2023

IJMS

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Hericium erinaceus is a valuable mushroom known for its strong bioactive properties. It shows promising potential as an excellent neuroprotective agent, capable of stimulating nerve growth factor release, regulating inflammatory processes, reducing oxidative stress, and safeguarding nerve cells from apoptosis. The active compounds in the mushroom, such as erinacines and hericenones, have been the subject of research, providing evidence of their neuroprotective effects. Further research and standardization processes for dietary supplements focused on H. erinaceus are essential to ensuring effectiveness and safety in protecting the nervous system. Advancements in isolation and characterization techniques, along with improved access to pure analytical standards, will play a critical role in achieving standardized, high-quality dietary supplements based on H. erinaceus. The aim of this study is to analyze the protective and nourishing effects of H. erinaceus on the nervous system and present the most up-to-date research findings related to this topic.

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Subchronic toxicity and genotoxicity studies of Hericium erinaceus β-glucan extract preparation

Cited by 5 publications

References 38 publications

Analysis of Biochemical and Genetic Variability of Pleurotus ostreatus Based on the β-Glucans and CDDP Markers

Analysis of Biochemical and Genetic Variability of Pleurotus ostreatus Based on the β-Glucans and CDDP Markers

Unveiling the Chemical Composition and Biofunctionality of Hericium spp. Fungi: A Comprehensive Overview

Neurotrophic and Neuroprotective Effects of Hericium erinaceus

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