Subchronic hydrocortisone treatment alters auditory evoked potentials in normal subjects

Abstract

The results indicate that subchronic hydrocortisone treatment in normal subjects increases the amplitude of auditory evoked potentials, possibly reflecting a central alerting effect.

Steroids That Induce Lung Maturation Acutely Affect Higher Cortical Function: A Fetal Magnetoencephalography Study

“…36,39 Amplitudes of CAER were shown to be influenced by steroid application in adults. 39,40 They are generally small in fMEG and cannot be considered a dependent parameter because of the varying distance between sensors and source but may have an impact on overall detection. 28…”

“…In 2 other studies neither the short latency auditory brain stem response nor the visually evoked cortical response were affected in premature newborns by antenatal steroid exposure. 36,39 Amplitudes of CAER were shown to be influenced by steroid application in adults. 39,40 They are generally small in fMEG and cannot be considered a dependent parameter because of the varying distance between sensors and source but may have an impact on overall detection.…”

“…36,39 Amplitudes of CAER were shown to be influenced by steroid application in adults. 39,40 They are generally small in fMEG and cannot be considered a dependent parameter because of the varying distance between sensors and source but may have an impact on overall detection. 28 That the cortical function of premature fetuses is primarily affected is in agreement with the data from Colberg et al, showing a more pronounced decrease in synaptic density to betamethasone exposure in fetal sheep at 0.7 gestation compared to fetal sheep at 0.83 gestation.…”

Early-Life Stress Impairs Perception and Neural Encoding of Rapid Signals in the Auditory Pathway

“…Children raised in these situations have been shown to have altered gray matter volume in ACx and diminished auditory fiber tract integrity (Teicher et al, 2016), lower amplitude auditory brainstem responses (ABRs) (Skoe et al, 2013), and poorer performance on speech perception tasks (Nittrouer and Burton, 2005). Although the underlying mechanisms may differ, stress induced during adulthood alters auditory perceptual sensitivity (Ashton et al, 2000; Hasson et al, 2013; Perez et al, 2013) and alters neural morphology and response properties in ACx and inferior colliculus, the auditory hub of the midbrain (Bose et al, 2010; Dagnino-Subiabre et al, 2012; Ma et al, 2015). Thus, ELS may have widespread effects on the auditory pathway and even the auditory periphery; for example, a corticotropin-releasing factor signaling system is active in the cochlea (Vetter and Yee, 2018).…”

Corticosterone Modulates Auditory Gating in Mouse

“…Acute and subchronic administration of hydrocortisone transiently enhanced amplitude of AEPs in normal subjects (Ashton et al, 2000;Born et al, 1989). However, repeated corticosteroid administration impaired performance on memory tasks, suggesting that behavioral outcomes may be dependent on the dose or length of corticosteroid exposure and perhaps homeostatic modulation of endogenous systems that result from exogenous administration (McAllister-Williams and Rugg, 2002).…”