Subcentimeter lung nodules stable for 2 years at LDCT: Long‐term follow‐up using volumetry

Abstract

All solid subcentimeter nodules having initial 2-year stability at screening LDCT can be considered benign because none shows growth at further follow-up CT. On the other hand, subcentimeter GGNs have more chance of growth than solid nodules and need further follow-up CT for more than 2 years.

Long-Term Follow-up of Small Pulmonary Ground-Glass Nodules Stable for 3 Years: Implications of the Proper Follow-up Period and Risk Factors for Subsequent Growth

“…This result corresponds well with that of the earlier study, which reported the long-term follow-up results of 2-year stable subcentimeter nodules including both solid nodules and GGNs. 22 GGNs on thick sections when they are actually solid. 11 Interestingly, all GGNs measuring less than 5 mm (154 pure GGNs and 1 part-solid GGNs), which had been stable during the initial 3-year follow-up period, did not grow after the period in our study.…”

Probability of cancer in high‐risk patients predicted by the protein‐based lung cancer biomarker panel in China: LCBP study

“…23,24 Currently in China, the procedures for the early diagnosis of lung cancer are primarily localized in general hospitals. 23,24 Currently in China, the procedures for the early diagnosis of lung cancer are primarily localized in general hospitals.…”

“…Many factors contribute to the delay of diagnosis of lung cancer, such as failure to recognize abnormal imaging results, failure to perform key diagnostic procedures within a short period, and misinterpretation of pathology reports. 23,24 Currently in China, the procedures for the early diagnosis of lung cancer are primarily localized in general hospitals. To improve the efficiency and efficacy of lung cancer diagnosis in China, there are 2 ongoing prospective clinical lung cancer screening trials based on serum biomarker panels: the Early Cancer Detection Test-Lung Cancer Scotland (ECLS Study) 25 and the blood-based lung cancer biomarkers screening study.…”

Year in review 2014: Lung cancer, pleural diseases, respiratory infections and tuberculosis, bronchoscopic intervention and imaging

“…Although the National Lung Cancer Screening Trial (NLST) demonstrated that the application of lowdose computed tomography (LDCT) is useful for reducing lung cancer-related mortality, 8 whether the detection of subcentimeter non-calcified nodules without changes in size over a 2-year follow-up period are indicative of malignancy or should be further followed up remains unknown. Shin et al 9 performed a retrospective study to answer this question. The authors investigated 635 subjects who received follow-up for LDCT for an initial 2-year screening period with three additional years thereafter in whom non-calcified subcentimeter nodules were evaluated.…”