Subcellular distribution of selenium and Se-containing proteins in human liver

Chen, C

doi:10.1016/s0304-4165(99)00013-6

Cited by 44 publications

(21 citation statements)

References 28 publications

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“…The lungs and the gastrointestinal tract are in constant contact with the external environment so it is not surprising to find that these systems are primary exposure sites for NMs (Chen et al, 1999;Sadauskas et al, 2009). It has been shown that different types of NMs can translocate from these primary exposure sites (Sadauskas et al, 2009).…”

Section: Abbreviationsmentioning

confidence: 99%

Toxicological effect of engineered nanomaterials on the liver

Kermanizadeh

Gaiser

Johnston

et al. 2014

British J Pharmacology

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The liver has a crucial role in metabolic homeostasis, as it is responsible for the storage, synthesis, metabolism and redistribution of carbohydrates, fats and vitamins, and numerous essential proteins. It is also the principal detoxification centre of the body, removing xenobiotics and waste products by metabolism or biliary excretion. An increasing number of studies have shown that some nanomaterials (NMs) are capable of distributing from the site of exposure (e.g. lungs, gut) to a number of secondary organs, including the liver. As a secondary exposure site the liver has been shown to preferentially accumulate NMs (>90% of translocated NMs compared with other organs), and alongside the kidneys may be responsible for the clearance of NMs from the blood. Research into the toxicity posed by NMs to the liver is expanding due to the realization that NMs accumulate in this organ following exposure via a variety of routes (e.g. ingestion, injection and inhalation). Thus it is critical to consider what advances have been made in the investigation of NM hepatotoxicity, as well as appraising the quality of the information available and gaps in the knowledge that still exist. The overall aim of this review is to outline what data are available in the literature for the toxicity elicited by NMs to the liver in order to establish a weight of evidence approach (for risk assessors) to inform on the potential hazards posed by NMs to the liver. LINKED ARTICLESThis article is part of a themed section on Nanomedicine. To view the other articles in this section visit http://dx

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Section: Abbreviationsmentioning

confidence: 99%

Toxicological effect of engineered nanomaterials on the liver

Kermanizadeh

Gaiser

Johnston

et al. 2014

British J Pharmacology

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“…Several studies have demonstrated that NMs entering the body via the lungs, ingestion or direct injection accumulate in the liver [7][8][9]. In previous studies, it has been shown that hepatocytes are capable of producing potent neutrophil chemoattractants (human-IL8 [15,16,18,19] rat-CINC-3) [20], following exposure to foreign matetrials, or in disease models.…”

Section: Resultsmentioning

confidence: 99%

“…Research indicates that NMs administered via ingestion, inhalation or intravenous injection rapidly reach secondary tissues, especially the liver [7][8][9]. As a secondary exposure site, the liver has huge importance, as it has been shown to accumulate NMs at high volumes (>90%), compared to other organs [9,10], and alongside the kidneys, may be responsible for the clearance of NMs from the blood [7][8][9]. The prominent advances in the field of nanomedicine have resulted in an increase in direct entry of NMs into the circulatory system.…”

Section: Introductionmentioning

confidence: 99%

Engineered Nanomaterial Impact in the Liver following Exposure via an Intravenous Route–The Role of Polymorphonuclear Leukocytes and Gene Expression in the Organ

Kermanizadeh¹,

Brown²,

Hutchison

et al. 2012

J Nanomedic Nanotechnol

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“…It functions in the active site of a large number of selenium-dependent enzymes such as glutathione peroxidase and is associated with anticancer and other physiological functions (Ip et al, 2000;Miller et al, 2001). The lack of Se in food may cause different diseases such as cardiovascular disease (Shamberger et al, 1978), cancer (Schrauzer et al, 1977;Salonen et al, 1984), rheumatoid arthritis (Tarp et al, 1985), cataract (Fecondo & Augusteyn, 1983) and anemia (Chen et al, 1999). The major forms of selenium occurring in foodstuffs are the organic, protein-associated forms, selenomethionine (SeMet, plant and animal sources) and selenocysteine (SeCys, animal sources).…”

Section: Selenium-rich Microalgaementioning

confidence: 99%