Dietary Antioxidants: From Micronutrients and Phytochemicals to Enzymes - Preventive Effects on Early Atherosclerosis and Obesity

Gaillet, Sylvie; La, Dominique; Rouanet, Jean-Max

doi:10.5772/35090

Cited by 1 publication

(3 citation statements)

References 126 publications

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“…Golden Syrian hamsters when fed on a fatrich diet developed dyslipidemia and atherosclerotic plaques, the symptoms are similar in many respects to human atheroma. 30 A close correlation exists between the increased oxidative stress in accumulated fat and the pathogenic mechanism of obesity and obesity-associated metabolic syndrome. 30 Alternatively, the atherosclerosis oxidation theory shows that the inhibition of LDL oxidation may also inhibit atherosclerosis, independent of lowering plasma cholesterol concentrations.…”

Section: High Fat Diet Induced Oxidative Stressmentioning

confidence: 99%

“…30 A close correlation exists between the increased oxidative stress in accumulated fat and the pathogenic mechanism of obesity and obesity-associated metabolic syndrome. 30 Alternatively, the atherosclerosis oxidation theory shows that the inhibition of LDL oxidation may also inhibit atherosclerosis, independent of lowering plasma cholesterol concentrations. 30 Polyphenolics present in rhizoma A. officinarum played the main role in ameliorating dyslipidemia Dietary polyphenols (DPP) are associated with a lower risk of cardiovascular disease.…”

Section: High Fat Diet Induced Oxidative Stressmentioning

confidence: 99%

“…30 Alternatively, the atherosclerosis oxidation theory shows that the inhibition of LDL oxidation may also inhibit atherosclerosis, independent of lowering plasma cholesterol concentrations. 30 Polyphenolics present in rhizoma A. officinarum played the main role in ameliorating dyslipidemia Dietary polyphenols (DPP) are associated with a lower risk of cardiovascular disease. 31 DPP positively reduced fasting and postprandial triglyceride-rich lipoprotein (TRLs) and associated oxidative stress.…”

Section: High Fat Diet Induced Oxidative Stressmentioning

confidence: 99%

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Antihyperlipidemic bioactivity of Alpinia officinarum (Hance) Farw Zingiberaceae can be attributed to the coexistance of curcumin, polyphenolics, dietary fibers and phytosterols

Peng

Yeh

et al. 2015

Food Funct.

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Rhizoma A. officinarum (Hance) Farw, synonymously is called rhizoma galangae or smaller galangal (hereafter abbreviated as AO). Numerous studies reported that AO possesses anti-inflammatory, anticancer, chemoprotective, antibacterial, antifungal and diuretic properties. To understand whether AO exhibits antihyperlipidemic bioactivity and what is the mechanism of action, we performed chemical and animal studies using hamsters (age: 4 weeks, body weight: 45 ± 4 g). The grouping of the animals was as follows: control, high fat (HF) diet, HF + AO2%, HF + AO4%, HF + AO6%, HF + AO8% and HF + AO10%. AO contained curcumin 5.67 mg g(-1) (on wet basis), crude fiber 1.3% ± 0.0%, soluble diet fiber 92 ± 2 mg g(-1), insoluble diet fiber 502 ± 5 mg g(-1), and phytosterols 63.9 ± 1.6 mg/100 g. Its methanolic extract consisted of high polyphenolics 4927.8 ± 101.1 mgGAE/100 g and flavonoids 593.2 ± 22.2 mgQE/100 g. The enlarged organs, including liver, kidney, and spleen, which were elicited by HF were completely alleviated by AO supplement diets. Levels of serum cholesterol, triglyceride, LDL-C, HDL-C and LDL-C/HDL-C ratio for the control originally were 138 ± 6, 98 ± 4, 40 ± 5, 168 ± 7 mg dL(-1) and 0.24, which were elevated by HF to 319 ± 12, 223 ± 13, 108 ± 11, 194 ± 6 mg dL(-1) and 0.05, and alleviated completely by HF + AO8% and HF + AO10%. In vitro, AO extracts showed potent DPPH free radical-scavenging and superoxide anion scavenging capabilities. In vivo, AO (at dose ≥8%) dose-dependently alleviated levels of superoxide dismutase, catalase, GSH, and MDA to 117 ± 6.9 U mL(-1), 32.9 ± 3.7 U mL(-1), 7.0 ± 1.7 μmol mL(-1) and 1.8 ± 0.4 nmol L(-1), respectively, exhibiting the remarkable antioxidative and antihyperlipidemic effects of AO. Conclusively, we are the first to report the occurrence of curcumin in rhizoma A. officinarum. Curcumin synergistically elicits promising anti-dyslipidemic bioactivity with coexisting total polyphenolics, dietary fibers and phytosterols.

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Section: High Fat Diet Induced Oxidative Stressmentioning

confidence: 99%