Subarachnoid Anesthesia with Pethidine

Mircea, N; Constantinescu, Cris S.; Jianu, E; Buşu, G; Ene, Catalina; Daşchievici, S; Nedelcu, A; Leoveanu, A

doi:10.1097/00132586-198308000-00047

Cited by 2 publications

(2 citation statements)

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“…Besides its hyperosmolality of 352.3 mosmol litre" 1 , other relevant physicochemical properties of the solution were: pH 4.354 and specific gravity 1.009. Although the specific gravity was close to the upper limit of the specific gravity of CSF, it has been demonstrated that the solution behaved as if hyperbaric (Mircea et al, 1982). Spinal anaesthesia was induced with the patient in the sitting position.…”

Section: Discussionmentioning

confidence: 99%

Saddle Block With Pethidine for Perineal Operations

Acalovschi

Ene

et al. 1986

British Journal of Anaesthesia

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Saddle blockade with pethidine hydrochloride was performed in 111 patients undergoing short surgical operations on the perineum. A dose of 5% pethidine 0.5 mg kg-1 was injected to the subarachnoid space at L4-5 or L5-S1 with the patient in the sitting position. Sensory blockade was achieved in 5.28 +/- 1.43 min. This extended to the sacrococcygeal area, perineum, buttocks and posterior surface of thighs, and was followed 1-2 min later by motor blockade. During the operation the patients were stable haemodynamically and no respiratory depression was recorded. Sensory blockade lasted for 141 +/- 26.06 min and was followed by postoperative analgesia, the mean duration of which was 301 +/- 98.38 min. Postoperative neurological complications were recorded in three patients (2.7%): headache alone in one, headache associated with backache in one, and leg weakness, backache, nuchal rigidity and photophobia in another. Seven patients (6.3%) complained of itching, five patients (4.5%) of nausea and vomiting and two (1.8%) developed urinary retention.

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Section: Discussionmentioning

confidence: 99%

Saddle Block With Pethidine for Perineal Operations

Acalovschi

Ene

et al. 1986

British Journal of Anaesthesia

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“…It has been used in place of, or in combination with conventional local anesthetics, for skin infiltration, spinal, and plexus anesthesia. [1][2][3][4][5][6][7] At clinical doses and concentrations, the local anesthetic properties of meperidine are comparable to those of lidocaine. [1][2][3] Therefore, intrathecal and epidural administration of meperidine may potentially block sympathetic outflow, with resultant hemodynamic effects such as hypotension.…”

Section: Clinical Reportsmentioning

confidence: 99%

Epidural meperidine does not cause hemodynamic changes in the term parturient

Khaw

Kee

Critchley

2000

Can J Anesth/J Can Anesth

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Purpose: Meperidine has local anesthetic properties and, therefore, when given epidurally it has the potential to cause hemodynamic changes. Our objective was to study the hemodynamic effects of an analgesic dose of epidural meperidine (50 mg) in 34 ASA 1-2 term parturients scheduled for elective Cesarean section under epidural anesthesia. Methods: A lumbar epidural catheter was inserted and patients lay in the supine left wedge position. Intravenous fluid preload was withheld, and hemodynamic measurements comprising of mean arterial pressure, cardiac output and heart rate were made using automatic oscillotonometry (Dinamap 1486SX) and transthoracic electrical bioimpedance (Bomed NCCOM3). Following baseline measurements, the hemodynamic effects of sequential epidural injection of first, 10 ml saline, and 20 min thereafter, 50 mg meperidine diluted to 10 ml with saline, were recorded. Sensory blockade was assessed following each injection using loss of temperature discrimination to ice. Paired Student t tests were used to compare changes in hemodynamic variables.Results: Epidural meperidine produced a small increase from the saline values in the mean (SD) cardiac output of 5.81 ±1.44 to 6.04 ± 1.54 L·min -1 (P < 0.05), and mean arterial pressure of 77.1 ± 8.8 to 79.3 ± 9.9 mmHg (P < 0.05). Sensory changes, the upper level of which ranged from L1 to T1, were detected in 94% of patients given epidural meperidine. Epidural saline injection had no such hemodynamic effects, but produced a detectable sensory level in two patients. Conclusion: Epidural meperidine, 50 mg, caused minimal hemodynamic changes in term parturients.Objectif : La mépéridine présente les propriétés d'un anesthésique local et peut donc causer des changements hémo-dynamiques lorsqu'on en fait l'administration péridurale. Notre objectif était d'en étudier les effets hémodynamiques d'une dose analgésique de 50 mg chez 34 parturientes à terme, d'état physique ASA I-II, dont la césarienne était prévue sous anesthésie péridurale.Méthode : Un cathéter péridural lombaire a été inséré et les patientes ont été placées en décubitus dorsal, le flanc gauche soulevé par un coussin. Une précharge de liquide intraveineux n'a pas eu lieu et les mesures hémodynamiques comprenant la tension artérielle moyenne, le débit cardiaque et la fréquence cardiaque ont été réa-lisées par oscillométrie automatique (Dinamap 1486SX) et bio-impédance électrique transthoracique (Bomed NCCOM3). Les mesures de départ étant faites, on a mesuré ensuite les effets hémodynamiques de l'injection péridu-rale séquentielle de 10 ml de solution salée et, 20 min plus tard, de 50 mg de mépéridine diluée dans 10 ml de solution salée. Le blocage sensitif a été évalué après chaque injection en utilisant la perte de discrimination de la température de la glace. Les tests t de Student pour paires appariées ont été utilisés pour comparer les changements des variables hémo-dynamiques.Résultats : La mépéridine péridurale a produit une faible augmentation, à partir des valeurs provenant de la solution ...

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Subarachnoid Anesthesia with Pethidine

Cited by 2 publications

References 0 publications

Saddle Block With Pethidine for Perineal Operations

Saddle Block With Pethidine for Perineal Operations

Epidural meperidine does not cause hemodynamic changes in the term parturient

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