Saddle Block With Pethidine for Perineal Operations

Acalovschi, I; Ene, V.; E, Lörinczi; Nicolaus, F.

doi:10.1093/bja/58.9.1012

Cited by 57 publications

(9 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Because of its local anaesthetic effect on peripheral nerves pethidine may be the ideal analgesic for curettage. Previous in vivo studies demonstrated that when given intrathecally pethidine was effective as the sole anaesthetic for surgery of the perineum 19 and caesarean delivery 20 . Pethidine with a short duration of action, has been widely and routinely prescribed for moderate to severe pain in medical and surgical patients 21 22 .…”

Section: Discussionmentioning

confidence: 99%

Effect of paracetamol, dexketoprofen trometamol, lidocaine spray, pethidine & diclofenac sodium application for pain relief during fractional curettage: A randomized controlled trial

Açmaz¹,

Bayraktar²,

Aksoy³

et al. 2015

Indian J Med Res

View full text Add to dashboard Cite

Background & objectives:Patients frequently experience pain of moderate to severe degree during gynaecologic procedures. This prospective, randomized, placebo-controlled trial was aimed to investigate the analgesic efficacy of preoperative oral dexketoprofen trometamol, intravenous paracetamol, lidocaine spray, pethidine and diclofenac sodium on fractional curettage procedure.Methods:A total of 144 mutiparous women were randomly allocated to one of the six groups. The first group (control group) consisted of 22 participants and they did not receive any treatment. The second group had 26 participants receiving oral 25 mg dexketoprofen trometamol. The 23 participants of the third group received two puff lidocaine sprays on cervical mucosa. The forth group consisted of 25 participants receiving 100 mg pethidine. In the fifth group, the 23 participants received 1000 mg intravenous paracetamol and the sixth group consisted of 25 participants receiving diclofenac sodium.Results:Pethidine was the best choice for reducing pain score during curettage procedure (t2:intra-operative). All analgesic procedures were significantly effective in reducing pain during postoperative period (t3). Significant pain reduction was achieved for both intra- and postoperative period by using analgesics.Interpretation & conclusions: The results of our study showed that lidocaine puffs provided the best pain relief than the other analgesics used. Therefore, lidocaine may be considered as the first choice analgesic in fractional curettage (NCT ID: 01993589).

show abstract

Section: Discussionmentioning

confidence: 99%

Effect of paracetamol, dexketoprofen trometamol, lidocaine spray, pethidine & diclofenac sodium application for pain relief during fractional curettage: A randomized controlled trial

Açmaz¹,

Bayraktar²,

Aksoy³

et al. 2015

Indian J Med Res

View full text Add to dashboard Cite

show abstract

“…A local nerve blocking effect was also reported in human volunteers subjected to intravenous regional anaesthesia [3] or femoral nerve block [6]. Furthermore, as mentioned earlier, pethidine also has the ability to induce sensory and motor blockade when injected intrathecally in patients undergoing caesarean section [5], prostate [15] or perineal surgery [1]. The unspecific blockade lends support to a local anaesthetic action of pethidine.…”

Section: Discussionmentioning

confidence: 76%

Is intra-articular pethidine an alternative to local anaesthetics in arthroscopy?

Ekblom

Westman

Söderlund

et al. 1993

Knee Surg, Sports traumatol, Arthroscopy

View full text Add to dashboard Cite

We investigated the per- and postoperative pain-reducing effect of pethidine given intra-articularly (i. art.). Thirty patients subjected to knee joint arthroscopy, diagnostic and surgical procedures, were randomly assigned to one of three groups. Group A consisted of ten patients who received 250 mg prilocaine + 200 micrograms adrenaline (i. art.) in a volume of 50 ml, group B of ten patients who received 200 mg pethidine (i. art.) in 50 ml saline, and group C of ten patients who received 200 mg pethidine + 200 micrograms adrenaline (i. art.) in 50 ml saline. During arthroscopy the patients reported on pain intensity and discomfort using visual analogue scales. Ratings were low and did not differ significantly between the three groups. Two of three patients in each group requested additional analgesics or sedatives due to pain and discomfort, but again with no difference between the three groups. Postoperatively all patients rated their pain intensity at rest and during movement (at 0, 1, 2, 3, 4, 5, 6, 12 and 24 h). The patients receiving pethidine (group B) reported significantly less pain at rest and movement than group A patients, in general at 1-4 h postoperatively. A significant difference was detected between groups B and C at 4 h postoperatively. Calculating the total sum of pain scores, patients receiving pethidine (group B) reported significantly less pain both at rest and during movement than those receiving prilocaine (group A). Furthermore, patients in group B used significantly less analgesics than those in group A. Adrenaline did not potentiate the effect of pethidine.(ABSTRACT TRUNCATED AT 250 WORDS)

show abstract

“…This raises an interesting question. Intrathecal meperidine produces a sufficient degree of nerve block to perform surgery of the lower limbs and perineum (Acalovschi et al, 1986). This local effect of meperidine may be explained by its ability to block a variety of channels with EC 50 values under 200 μM, including voltage-activated Na+ channels, delayed rectifier K+ channels, the calcium-activated K+ channel, and the voltage-independent flicker K+ channel (Brau et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

Topical methadone and meperidine analgesic synergy in the mouse

Kolesnikov

Oksman

Pasternak

2010

European Journal of Pharmacology

View full text Add to dashboard Cite

Topical analgesics have many potential advantages over systemic administration. Prior work has shown potent analgesic activity of a number of topical opioids in the radiant heat tailflick assay. The current study confirms the analgesic activity of morphine and extends it to two other mu opioids, methadone and meperidine. Combinations of topical morphine and lidocaine are synergistic. Similarly, the combination of methadone and lidocaine is synergistic. While there appeared to be some potentiation with the combination of meperidine and lidocaine, it did not achieve significance. Systemically, prior studies have shown that co-administration of morphine and methadone was synergistic. The combination of morphine and methadone was also synergistic when given topically. In contrast, the combination of morphine and meperidine was not synergistic systemically and it was not synergistic topically. Thus, the pharmacology of topical opioids mimics that seen with systemic administration. Their activity in the topical model supports their potential utility while the local limitation of their actions offers the possibility of a reduced side-effect profile.

show abstract

Saddle Block With Pethidine for Perineal Operations

Cited by 57 publications

References 3 publications

Effect of paracetamol, dexketoprofen trometamol, lidocaine spray, pethidine & diclofenac sodium application for pain relief during fractional curettage: A randomized controlled trial

Effect of paracetamol, dexketoprofen trometamol, lidocaine spray, pethidine & diclofenac sodium application for pain relief during fractional curettage: A randomized controlled trial

Is intra-articular pethidine an alternative to local anaesthetics in arthroscopy?

Topical methadone and meperidine analgesic synergy in the mouse

Contact Info

Product

Resources

About