Subacute toxicity of methylmercury in the adult cat

Modulating effects of dietary fats on methylmercury toxicity and distribution in rats

“…Effects of MeHg on hematological characteristics have been reported in cats (Charbonneau et al, 1974), rats (Verschuuren et al, 1976a,b;Munro et al, 1980), and mice (Shaw et al, 1991). A single IP injection of 24 mg MeHg/kg BW induced a significant decrease in hemoglobin, RBC count, and Hct% values in mice after 4 and 14 days of exposure (Shaw et al, 1991).…”

“…It has been suggested that tissue fatty acid compositional changes may occur more rapidly after seal oil than fish oil treatment because of the absorption of readily available free n − 3 PUFA from seal oil to compete with arachidonic acid to inhibit its metabolism to eicosanoid production (Madland et al, 2006;Yoshida et al, 2001). Charbonneau et al (1974) reported an increase in neutrophil counts and a decrease in lymphocyte counts to a greater degree in cats given MeHg (0.25 mg/kg BW) in contaminated fish than in corn oil after over 3 months of exposure. We did not observe significant decrease in lymphocyte counts by MeHg treatment in rats fed any dietary fat.…”

A Screening Level Probabilistic Risk Assessment of Mercury in Florida Everglades Food Webs

“…Mercury levels in individual animals exceed Hg concentrations causing toxicity, including reduced survival (Eisler, 1987;Zillioux et al, 1993;Scheuhammer, 1991;Thompson, 1996). Also, Hg concentrations in some Florida panther carcasses have exceeded levels associated with Hg toxicity in other feline species (Charbonneau et al, 1974(Charbonneau et al, , 1976. Mercury risks were lowest for raccoons because of limited consumption of the largest, most contaminated fish; however, raccoons may serve as an important pathway of Hg exposure to Florida panthers.…”

Health effects of ingestion of mercury-polluted urban soil: an animal experiment

“…In addition, after the 120-day exposure period, the platelet quantity (PLT) was significantly increased (P \ 0.05) in groups AII, BIII, BIV, and CV (Table 4). Effects of MeHg on hematological characteristics have been reported in cats (Charbonneau et al 1974) and rats (Verschuuren 1976a(Verschuuren , 1976b(Verschuuren , 1976cMunro et al 1980). In mice, intraperitoneal injection of methylmercury induced a significant decrease in hemoglobin, RBC count, and HCT % values (Shaw et al 1991).…”