Subacute sclerosing panencephalitis and progressive multiple sclerosis

Członkowska, Anna; Korlak, J; Iwińska, B

doi:10.1212/wnl.36.7.992

Cited by 16 publications

(6 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In PB the ratio in most samples was also significantly lower than in normals and the mean values ranged from 1.2 to 1.51. Similar findings have been reported in subacute scleros ing panencephalitis [16]. In some clinically not defined cases of acute aseptic meningoencephalitis [17], the fol lowing ranges of the pecentage of CSF cell subsets were found: OKT3 53-83%, OKT4 33-65%, OKT8 13-45%.…”

Section: Discussionsupporting

confidence: 85%

Quantitation of Lymphocyte Subsets in Cerebrospinal Fluid and Blood during the Clinical Course of Aseptic and Bacterial Meningitis

Bamborschke

Wullen²,

Beil³

1990

Eur Neurol

View full text Add to dashboard Cite

Mononuclear cell subsets in cerebrospinal fluid (CSF) and peripheral blood (PB) were monitored during the clinical course in 23 patients with acute meningitis using 6 monoclonal antibodies. Significant differences between aseptic and bacterial meningitis mainly consisted of a higher percentage of OKT4-positive cells in PB in the acute phase of bacterial meningitis. Significant differences between CSF and PB are found in the amount of most cell subtypes at all times except the acute phase of bacterial meningitis. The OKT4/OKT8 ratio was always significantly higher in CSF and correlated with the acuity of inflammation in bacterial meningitis.

show abstract

Section: Discussionsupporting

confidence: 85%

Quantitation of Lymphocyte Subsets in Cerebrospinal Fluid and Blood during the Clinical Course of Aseptic and Bacterial Meningitis

Bamborschke

Wullen²,

Beil³

1990

Eur Neurol

View full text Add to dashboard Cite

show abstract

“…Whether distinctive CSF profiles will be found in encephalitides of other causes is unknown, but experience in the one patient without JE who had a very different pattern of cells gives some promise that identification of cells may prove useful in preliminary differential diagnosis of inflammatory disease. Similar reversal of ratios of T4K8 cells in CSF has been seen in chronic diseases, including cytomegalovirus encephalitis [22}, subacute sclerosing panencephalitis [7,191, and tuberculous meningitis {personal observation, 19841. However, the T8 monoclonal antibody does not differentiate suppressor T cells from the cytotoxic T cells that may be important in these chronic inflammatory diseases.…”

Section: Discussionmentioning

confidence: 64%

Japanese encephalitis: Idenufication of inflammatory cells in cerebrospinal fluid

Johnson

Intralawan

Puapanwatton

1986

Annals of Neurology

View full text Add to dashboard Cite

Fifteen patients with acute encephalitis were studied during the epidemic season of Japanese encephalitis (JE) in Northern Thailand; 13 of 15 proved to have the encephalitis. In serial cerebrospinal fluids and blood samples, mononuclear cells were identified using monoclonal antibodies. In cerebrospinal fluid from the patients with Japanese encephalitis, T cells predominated with a 4.2:1 ratio of T helper/inducer cells to T suppressor/cytotoxic cells; B cells and macrophages were often present but in small numbers compared to their presence in blood. Distribution of cell types did not vary between the first and fifth day of hospitalization, were similar in fatal and nonfatal cases, and were unaffected by administration of steroids.

show abstract

“…States in 2018-2019 and in Australia and New Zealand in 2019. 25,26 We feel that these outbreaks should be considered warning signs of a possible epidemic slowing taking shape. Occurrence of SSPE, even in those who were vaccinated, should also be a red flag in terms of vaccine-efficacy (in those with immune dysregulation) and those developing immunity after a natural infection with measles (immuneevasion leading to persistence of latent measles virus in the body).…”

Section: Resultsmentioning

confidence: 99%

“…The correlation between SSPE and the polymorphisms in the IL‐2, IL‐12, and IFN‐ genes was evaluated by Yilmaz et al 24 Their study revealed that SSPE patients had considerably higher IL‐12 gene polymorphism rs3213113 and the IL‐2 gene polymorphism rs2069762 than the controls. Aspect of vaccination become important in view of resurgence of measles outbreak in United States in 2018–2019 and in Australia and New Zealand in 2019 25,26 . We feel that these outbreaks should be considered warning signs of a possible epidemic slowing taking shape.…”

Section: Discussionmentioning

confidence: 98%

“…We observed that the absolute lymphocyte count, B cell, T cell, Th cell and Tc cell levels were significantly higher among cases ( p < 0.05) when compared with healthy controls. Członkowska et al studied T cells subset in SSPE patients and found that T helper cells level was deceased and cytotoxic T cells were elevated in both blood and CSF 26 …”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Immune‐dysregulation in subacute sclerosing panencephalitis: An exploratory case–control study

Vijayvarman

Malhotra

Rizvi

et al. 2023

Journal of Medical Virology

View full text Add to dashboard Cite

Subacute sclerosing panencephalitis (SSPE) is a chronic progressive neurological condition caused by a defective measles virus. It is postulated that immune‐dysregulation might result in persistent infection (immune evasion) as well as initiation of autoimmune phenomenon (via natural killer cells) leading to panencephalitis. The primary objective of this case‐control study was to analyse the pattern of immune dysregulation in cases with SSPE. The secondary objective was to assess the correlation between the measured immunological variables and disability/death at 6 months. This was an exploratory case–control study conducted at a tertiary‐care referral‐facility from January 2020 to September 2021. Thirty consecutive patients fulfilling the Dyken's criteria for SSPE and 30 age‐and‐sex‐matched healthy controls were enrolled. Immunological profile constituted by lymphocyte subset analysis, immunoglobulin levels and complement levels were done in all cases and controls. Cases were staged as per Jabbour's system; disability was assessed using the modified Rankin Scale (mRS). Patients with SSPE had a mean age of 14.76 years (±6.9 years). There were 25 males and 5 females; 6.7% cases belonged to Jabbour's first stage, 40% to second stage and 53.3% to third stage. At least 1/4th had evidence of measles vaccination. Levels of absolute lymphocyte count, B‐cells, T cells, helper T‐cells, and cytotoxic T‐cells were significantly higher in cases. IgG, IgM, and IgE levels were significantly higher while IgD levels were significantly lower in cases. At baseline, 13.3% of cases had a mRS score of 0–2 and 86.7% had a score of 3–6; at 6 months 10% had a mRS score 0–2 (favorable outcome) while 90% had a mRS score 3–6 (poor outcome). Higher IgE levels were found to correlate significantly with favorable outcome. Immune‐dysregulation may play a significant role in shaping one's response to measles infection as well as in determining vaccine‐efficacy.

show abstract

Subacute sclerosing panencephalitis and progressive multiple sclerosis

Cited by 16 publications

References 0 publications

Quantitation of Lymphocyte Subsets in Cerebrospinal Fluid and Blood during the Clinical Course of Aseptic and Bacterial Meningitis

Quantitation of Lymphocyte Subsets in Cerebrospinal Fluid and Blood during the Clinical Course of Aseptic and Bacterial Meningitis

Japanese encephalitis: Idenufication of inflammatory cells in cerebrospinal fluid

Immune‐dysregulation in subacute sclerosing panencephalitis: An exploratory case–control study

Contact Info

Product

Resources

About