Subacute sclerosing panencephalitis

Ohya, Tatsuo; Martínez, A. Julio; Jabbour, J. T.; Lemmi, Hélio; Duenas, Danilo A.

doi:10.1212/wnl.24.3.211

Cited by 74 publications

(33 citation statements)

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“…Our observations of abnormal DTI measures in patients with SSPE can be explained by pathologic changes, like astrogliosis, neuronal loss and degeneration, demyelination, neurofibrillary tangles, and infiltration of inflammatory cells. [27][28][29][30] Significant inverse correlation of mean FA with clinical grades suggests that FA is a better measure than conventional MR imaging for the assessment of clinical grade in these patients.…”

Section: Discussionmentioning

confidence: 99%

“…31 In the later phase of the disease, the inflammation subsides, leading to demyelination, necrosis, and gliosis. 28 The posterior regions, especially the parieto-occipital and posterotemporal areas, are predominantly affected early in the course of the disease. 32 The conventional MR imaging findings usually appear normal in the early stages, with sequential involvement of posterior parts of the cerebral hemisphere as the disease progresses.…”

Section: Discussionmentioning

confidence: 99%

“…Pyramidal signs and symptoms usually develop in higher grades of SSPE. 28 Motor impairments have been attributed to the injury of CST fibers. A DTI study in patients with SSPE has indicated significantly decreased FA in the posterior limb of the internal capsule in patients with SSPE compared with healthy controls, even in the absence of motor dysfunction.…”

Section: Discussionmentioning

confidence: 99%

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Correlation of Quantitative Diffusion Tensor Tractography with Clinical Grades of Subacute Sclerosing Panencephalitis

Trivedi

Anuradha²,

Agarwal³

et al. 2011

AJNR Am J Neuroradiol

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Correlation of Quantitative Diffusion Tensor Tractography with Clinical Grades of Subacute Sclerosing Panencephalitis

Trivedi

Anuradha²,

Agarwal³

et al. 2011

AJNR Am J Neuroradiol

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“…Previous autopsy reports revealed that inflammatory infiltrations in cortical gray matter are the prominent pathologic finding in the early periods of SSPE. 1,15 In later stages of the disease, the neuropathologic findings spread into adjacent subcortical white matter. Early involvement of cortical gray matter would explain the nonspecific subtle behavioral symptoms that are frequently seen in the initial stages of SSPE.…”

Section: Commentmentioning

confidence: 99%

Reduced Gray Matter Volume in the Frontotemporal Cortex of Patients with Early Subacute Sclerosing Panencephalitis

Aydın¹,

Okur²,

Tatlı³

et al. 2008

AJNR Am J Neuroradiol

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“…This may, in part, reflect involvement of cortical and subcortical neurons 5,8,10 . It is possible that in our patient the disease had an initial involvement of a limited cortical area with posterior extension to subcortical and brain stem regions…”

Section: Commentsmentioning

confidence: 99%

Atypical clinical and electroencephalographic pattern in a patient with subacute sclerosing panencephalitis

Silva

Lima²,

Anghinah³

et al. 1995

Arq. Neuro-Psiquiatr.

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SUMMARY -We describe an atypical clinical and electroencephalographic (EEG) pattern observed during the course of subacute sclerosing panencephalitis in a 14 year-old boy. In this patient with a two weeks history of partial complex seizures, the atypical EEG pattern was characterized by an initial left temporal focus which evolved to periodic lateralized epileptiform discharges (PLEDs) and, only during the 3 rd and 4 th weeks the typical bilateral and generalized periodic complexes appeared.KEY WORDS: subacute sclerosing panencephalitis, EEG, periodic complexes, partial complex seizure.Since the early reports of Radermecker (1949) 12 and Cobb and Hill (1950) 2 , the great diagnostic value of electroencephalographic (EEG) findings in subacute sclerosing panencephalitis (SSPE) has been outlined by numerous workers. As is well known, the characteristic EEG pattern consists of high-voltage and polymorphic periodic complexes, recurring at long intervals, grossly widespread throughout both hemispheres 3 that are often associated with motor spasms.In the case reported here, the patient presented partial complex seizures and an atypical EEG finding, making the diagnosis more difficult. We are aware of only one study of SSPE with partial complex seizures 9 . REPORT OF CASEHJ, a 14-year-old boy had partial complex seizures two weeks before being seen at the Escola Paulista de Medicina, that were characterized by loss of consciousness, staring, verbal and gestual automatisms, several times per day. Also, cognitive and intellectual deterioration had developed. A diagnosis of partial complex seizures and behavioural disturbance were made. Despite treatment with anticonvulsants (carbamazepine) the * Head of the EEG Sector, Escola Paulista de Medicina (EPM); **Junior Doctor of the EEG Sector; ***Resident in Neurology; ****Full Professor and Head of the Discipline of Neurology, EPM. Aceite: 2-janeiro-1995.Dr. Délrio Façanha da Silva -Disciplina de Neurologia, Setor de Eletrencefalografia, Escola Paulista de MedicinaPadrão clínico e eletrencefalográfico atípico em um paciente com panencefalite esclerosante subaguda RESUMO -Descrevemos o quadro clínico e eletrencefalográfico atípicos observados durante a evolução de panencefalite esclerosante subaguda, em um menino de 14 anos. Neste paciente, com história de crises parciais complexas há duas semanas, o padrão eletrencefalográfico atípico foi caracterizado por foco temporal esquerdo que evoluiu para "periodic lateralized epileptiform discharges" (PLEDs), somente durante a 3 a e 4 a semanas surgindo os clássicos complexos periódicos difusos. PALAVRAS-CHAVE: panencefalite esclerosante subaguda, EEG, complexos periódicos, crise parcial complexa.

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Subacute sclerosing panencephalitis

Cited by 74 publications

References 0 publications

Correlation of Quantitative Diffusion Tensor Tractography with Clinical Grades of Subacute Sclerosing Panencephalitis

Correlation of Quantitative Diffusion Tensor Tractography with Clinical Grades of Subacute Sclerosing Panencephalitis

Reduced Gray Matter Volume in the Frontotemporal Cortex of Patients with Early Subacute Sclerosing Panencephalitis

Atypical clinical and electroencephalographic pattern in a patient with subacute sclerosing panencephalitis

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