Subacute poisoning of mice with deltamethrin produces memory impairment, reduced locomotor activity, liver damage and changes in blood morphology in the mechanism of oxidative stress

Nieradko-Iwanicka, Barbara; Borzęcki, Andrzej

doi:10.1016/j.pharep.2014.12.012

Cited by 43 publications

(20 citation statements)

References 37 publications

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“…It is known that pyrethroids can target neurons and influence physical activities in arthropods as well as mammals (Baatrup et al, 1993; Crofton et al, 1988; Frank et al, 2000; Nieradko-Iwanicka et al, 2015). It was previously shown that daily intraperitoneal injection of deltamethrin, at doses higher than we used in the current report (8.3–41.5 mg/kg body weights for 1–28 days), significantly decreased locomotive activity in female mice (Nieradko-Iwanicka et al, 2015). Because of its lipophilic nature, permethrin was found to accumulate in the nervous system at 1.5~7.5 times higher levels than in plasma after oral administration (Anadon et al, 1991).…”

Section: Discussionmentioning

confidence: 99%

Permethrin alters glucose metabolism in conjunction with high fat diet by potentiating insulin resistance and decreases voluntary activities in female C57BL/6J mice

Xiao

Kim

et al. 2017

Food and Chemical Toxicology

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Permethrin, a type 1 pyrethroid insecticide, was previously reported to promote adipogenesis in 3T3-L1 adipocytes and insulin resistance in C2C12 muscle cells; however, the effects of permethrin exposure on glucose and lipid metabolisms in vivo remain unknown. The purpose of this study was to investigate the effects of permethrin exposure on glucose and lipid homeostasis as well as voluntary movement in female mice in response to dietary fat. We tested three doses of permethrin (50, 500, & 5000 μg/kg body weight/day) in low fat diet-fed (4% w/w of diet) and high fat diet-fed (20% w/w of diet) female C57BL/6J mice for twelve weeks. Our results demonstrated that permethrin treatment potentiated high fat diet-induced insulin resistance as indicated by insulin tolerance tests, glucose tolerance tests, and homeostasis model assessment - insulin resistance (HOMA-IR) without altering weight or fat mass. Permethrin treatment significantly decreased voluntary movement and elevated blood glucose and insulin levels. Western blot results further showed that permethrin impaired insulin signaling via the Akt signaling pathway in the gastrocnemius muscle. Taken together, these results suggest that oral administration of permethrin potentiated high fat diet-induced insulin resistance, possibly increasing the risk of type 2 diabetes without altering weight gain in female C57BL/6J mice.

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Section: Discussionmentioning

confidence: 99%

Permethrin alters glucose metabolism in conjunction with high fat diet by potentiating insulin resistance and decreases voluntary activities in female C57BL/6J mice

Xiao

Kim

et al. 2017

Food and Chemical Toxicology

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“…A recent study states the "possible mechanism" of the damage by DLM at liver and bone marrow is oxidative stress. [37] This study shows that insecticide toxicity causes oxidative stress and oxidant or free radicals have a major role so plasma MDA and GSH level measurements can be used for insecticide toxicity evaluation. Although plasma MDA and GSH level measurements are not specific to a particular disease or toxicity, they can be used for monitorization of DLM toxicity rather than diagnosis.…”

Section: Discussionmentioning

confidence: 89%

The effects of subacute deltamethrin exposure on rat liver: histochemical, immunohistochemical, and biochemical study

Çavuşoğlu¹,

Aydın²,

Çağıltay³

et al. 2016

FNG & Bilim Tıp Dergisi

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Objectives: This study aims to determine deltamethrin's effects on early diagnosis of toxicity and liver toxicity markers in an animal model. Materials and methods: A total of 36 male rats weighing 200-220 gram were separated into four groups. Group 1 rats were given deltamethrin 15 mg/kg/day, group 2 rats were given deltamethrin 30 mg/kg/day, group 3 rats were given deltamethrin 60 mg/kg/day, and group 4 rats (control group) were given 0.9% sodium chloride 1 mL/kg/day for 30 days by oral gavage. Results: Deltamethrin ingestion resulted in edema, nuclear hypertrophy, and parenchymal and stromal inflammation on the histopathological examination. Malondialdehyde levels increased and glutathione levels decreased when compared with the control group as the treatment dose increased. Alanine transaminase levels increased significantly when compared with the control group. The changes correlated directly with increasing dose. Conclusion: Deltamethrin usage causes liver toxicity in a dose dependent manner on rats. This toxicity is observed both biochemically and histopathologically. Liver biomarkers and oxidative stress parameters can effectively be used for potential toxicity monitorization.

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“…The rampant use of mosquito repellants are of a serious concern for health and the environment, and their easy availability and widespread use are responsible for frequent poisoning . It has been reported that exposure to pesticides is associated with increased risk of degenerative as well as various other pathological disorders . Oxidative stress plays a crucial role in the development of several diseases such as atherosclerosis, cancer, diabetics, rheumatoid arthritis, myocardial infarction, autoimmune disease, and aging .…”

Section: Discussionmentioning

confidence: 99%

“…21 It has been reported that exposure to pesticides is associated with increased risk of degenerative as well as various other pathological disorders. 22,23 Oxidative stress plays a crucial role in the development of several diseases such as atherosclerosis, cancer, diabetics, rheumatoid arthritis, myocardial infarction, autoimmune disease, and aging. 24,25 Administration of insecticides in acute or sub-acute doses in experimental animals has been shown to result in deviation from normal structure and function of the lung, liver, and kidney mainly due to oxidative stress 26,27 .…”

Section: Discussionmentioning

confidence: 99%

Oxidative stress and neuromodulatory effects of deltamethrin and its combination with insect repellents in rats

Magesh

Anitha

Vijayaraghavan

et al. 2019

Environmental Toxicology

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Deltamethrin (DEL) and other synthetic repellents like N,N‐diethyl benzamide (DEB), N,N‐diethyl phenylacetamide (DEPA), and N,N‐diethyl meta toluamide (DEET) are widely used due their high efficacy against mosquitoes. We evaluated the safe dose on exposure to insecticide and insect repellent individually and in combination in Wistar rats. Rats were administrated with individual chemicals DEL, DEB, DEPA, and DEET and in combination of DEL along DEB, DEPA, and DEET. The reduced glutathione and its detoxifying enzymes were significantly increased in DEL treated rats. Serotonin, dopamine, and noradrenaline were increased in DEL alone and its combination groups. Histopathology revealed that DEL and along with other insect repellants can cause lung toxicities. This study suggests that DEL in combination with other insect repellents showed antagonistic effect against oxidative stress, and there was no significant toxicological effect in the combination groups. The insect repellents with DEL cause less toxic effect and is safe for use.

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Subacute poisoning of mice with deltamethrin produces memory impairment, reduced locomotor activity, liver damage and changes in blood morphology in the mechanism of oxidative stress

Abstract: The results obtained indicate that liver and bone marrow, apart from the central nervous system (CNS) are damaged in the course of subacute poisoning with DEL. The possible common mechanism of the damage is oxidative stress.

Cited by 43 publications

References 37 publications

Permethrin alters glucose metabolism in conjunction with high fat diet by potentiating insulin resistance and decreases voluntary activities in female C57BL/6J mice

Permethrin alters glucose metabolism in conjunction with high fat diet by potentiating insulin resistance and decreases voluntary activities in female C57BL/6J mice

The effects of subacute deltamethrin exposure on rat liver: histochemical, immunohistochemical, and biochemical study

Oxidative stress and neuromodulatory effects of deltamethrin and its combination with insect repellents in rats

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