Subacute oral toxicity study of ethynylestradiol and bisphenol A, based on the draft protocol for the 'Enhanced OECD Test Guideline no. 407'

Yamasaki, Kanji; Sawaki, Masakuni; Noda, Shuji; Imatanaka, Nobuya; Takatsuki, Mineo

doi:10.1007/s00204-001-0319-1

Cited by 78 publications

(52 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…CERHR also reviewed the studies that examined reproductive organs, and those studies are summarized in detail in the appropriate section of this report. A relevant study by Yamasaki et al (2002a) was published subsequent to the European Union review and was reviewed in detail by CERHR.…”

Section: General Toxicity the European Unionmentioning

confidence: 99%

“…In studies reviewed by the European Union (2003) and in a study by Yamasaki et al (2002a), rats were orally exposed to bisphenol A for periods of 28 days to 2 years. Cecal enlargement occurring at doses Z25 mg/kg bw/ day was the effect observed most frequently in those studies but was not considered toxicologically significant by the European Union.…”

Section: General Toxicity the European Unionmentioning

confidence: 99%

“…[A complete set of data for histopathological findings was not presented for rats or mice.] Yamasaki et al (2002a) examined the effects of bisphenol A exposure on male and female CD rats in a study conducted according to Good Laboratory Practices (GLP). [Because this study included a number of reproductive organ and hormone endpoints, it is also discussed in Sections 4.2.1.1 and 4.2.2.1.]…”

Section: General Toxicity the European Unionmentioning

confidence: 99%

“…Possible target organs or systems of toxicity identified in repeat-dose animal studies with oral dosing included intestine, liver, kidney, and male, and female reproductive systems [reviewed in (NTP, 1982;Yamasaki et al, 2002a;European-Union, 2003)]. Intestinal findings (effect levels) in rats included cecal enlargement (Z25 mg/kg bw/day) and cecal mucosal hyperplasia (Z200 mg/kg bw/day).…”

Section: Summary Of General Toxicology and Biologicmentioning

confidence: 99%

“…Yamasaki et al (2002a) conducted a 28-day exposure study that provided some information on the reproductive organs of male and female rats. [Complete details of this study are included in Section 2.…”

Section: Experimental Animalmentioning

confidence: 99%

See 4 more Smart Citations

NTP‐CERHR expert panel report on the reproductive and developmental toxicity of bisphenol A

Chapin

Adams

Boekelheide

et al. 2008

Birth Defects Research Pt B

401

304

View full text Add to dashboard Cite

Section: General Toxicity the European Unionmentioning

confidence: 99%

Section: General Toxicity the European Unionmentioning

confidence: 99%

Section: General Toxicity the European Unionmentioning

confidence: 99%

Section: Summary Of General Toxicology and Biologicmentioning

confidence: 99%

Section: Experimental Animalmentioning

confidence: 99%

See 3 more Smart Citations

NTP‐CERHR expert panel report on the reproductive and developmental toxicity of bisphenol A

Chapin

Adams

Boekelheide

et al. 2008

Birth Defects Research Pt B

401

304

View full text Add to dashboard Cite

The importance of appropriate controls, animal feed, and animal models in interpreting results from low-dose studies of bisphenol A

et al. 2005

View full text Add to dashboard Cite

Interpreting results of studies that report only negative effects is problematic. A number of published studies to determine whether chemicals with estrogenic activity can cause effects at low doses have not taken into account the possibility that the commercial animal feed being used can mask effects of even potent estrogenic drugs such as diethylstilbestrol (DES). In addition, the sensitivity of the strain of animal being used for the specific category of chemical being tested has not always been described. For environmental chemicals, such as the estrogenic polycarbonate plastic monomer bisphenol A, DES is an appropriate positive control for estrogenic effects, and using an appropriate low dose of DES can eliminate the possibility of false-negative conclusions of safety when the above or other variables contribute to the negative outcome. Only when simultaneous positive effects of low doses of a positive control chemical such as DES and negative effects of environmentally relevant low doses of the test chemical are demonstrated within the same experiment are conclusions of no effect of the test chemical warranted, and this has not been reported for bisphenol A in any study. Instead, more than 90 refereed journal publications have reported effects due to exposure to low doses of bisphenol A in a wide variety of animals (for references see: http://rcp.missouri.edu/endocrinedisruptors/ vomsaal/vomsaal.html). However, due to lack of attention to the importance of appropriate positive controls, a small number of studies reporting negative effects of bisphenol A have created a false sense of controversy regarding low-dose effects of bisphenol A.

show abstract

Novel toxicity of tris(1,3‐dichloro‐2‐propyl) phosphate in adult male rats

Kobayashi

Abe

Isobe

et al. 2020

J of Applied Toxicology

View full text Add to dashboard Cite

The widespread use of tris(1,3‐dichloro‐2‐propyl) phosphate (TDCIPP) as a flame retardant has led to its release to the environment. Thus, the toxicological effects of TDCIPP on humans and animals are of importance. For better understanding of its potential toxicities, TDCIPP (250, 500, or 650 mg/kg/day) or vehicle control was administrated orally to adult male Wistar‐Imamichi rats for 7 days. After the final administration of compounds, organ weights, histopathology, blood biochemistry, and hematology were examined. Hepatic toxicity was observed at doses ≥ 500 mg/kg/day of TDCIPP, and renal toxicity was observed at 650 mg/kg/day. The anti‐androgenic activity of TDCIPP was previously confirmed in vitro and in vivo, but weights of epididymis, an androgen‐dependent organ, were not affected by TDCIPP treatment in adults. Serum alkaline phosphatase activity was significantly decreased in all TDCIPP‐treated rats independent of dose. Hemoglobin concentration, hematocrit, red blood cell count, and reticulocyte count were decreased in all TDCIPP‐treated rats, but mean corpuscular volume, total iron‐binding capacity, and serum iron were normal, suggesting that renal anemia was caused by TDCIPP. Together with previous reports on effects of anti‐androgenic substances on red blood cell indices, anemia caused by TDCIPP could be due to its anti‐androgenic activity. These considerations will contribute to further assessment of the toxicity of the compound.

show abstract

Subacute oral toxicity study of ethynylestradiol and bisphenol A, based on the draft protocol for the 'Enhanced OECD Test Guideline no. 407'

Cited by 78 publications

References 6 publications

NTP‐CERHR expert panel report on the reproductive and developmental toxicity of bisphenol A

NTP‐CERHR expert panel report on the reproductive and developmental toxicity of bisphenol A

The importance of appropriate controls, animal feed, and animal models in interpreting results from low-dose studies of bisphenol A

Novel toxicity of tris(1,3‐dichloro‐2‐propyl) phosphate in adult male rats

Contact Info

Product

Resources

About