Subacute neocortical stimulation (SNCS) and its effects on epileptic activity in adults and children diagnosed with focal cortical dysplasia (FCD)

Freigang, Sascha; Jiménez‐Jiménez, Diego; Kazi, Farhana; Díaz-Díaz, Judit; Pina, Marisa; Cunha, Maria; Alarcón, Gonzalo; Selway, Richard; Valentı́n, Antonio

doi:10.1016/j.eplepsyres.2020.106392

Cited by 1 publication

(1 citation statement)

References 23 publications

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“…SCS delivers single pulses of electrical stimulation to the cortex 40 and has been previously used to identify epileptogenic tissue. 40,41 A recent study evaluated the diagnostic utility of SCS during presurgical iEEG assessment. SCS was continuously delivered through a pair of electrodes showing (1) fast activity at seizure onset, (2) delayed responses to single pulse electric stimulation, 42,43 and (3) the electrode that showed most frequent interictal epileptiform discharges, as these patterns are strongly related to good surgical outcome.…”

Section: Subacute Cortical Stimulationmentioning

confidence: 99%

WONOEP 2022: Neurotechnology for the diagnosis of epilepsy

Wagstyl,

Kobow,

Casillas‐Espinosa

et al. 2024

Epilepsia

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Epilepsy's myriad causes and clinical presentations ensure that accurate diagnoses and targeted treatments remain a challenge. Advanced neurotechnologies are needed to better characterize individual patients across multiple modalities and analytical techniques. At the XVIth Workshop on Neurobiology of Epilepsy: Early Onset Epilepsies: Neurobiology and Novel Therapeutic Strategies (WONOEP 2022), the session on “advanced tools” highlighted a range of approaches, from molecular phenotyping of genetic epilepsy models and resected tissue samples to imaging‐guided localization of epileptogenic tissue for surgical resection of focal malformations. These tools integrate cutting edge research, clinical data acquisition, and advanced computational methods to leverage the rich information contained within increasingly large datasets. A number of common challenges and opportunities emerged, including the need for multidisciplinary collaboration, multimodal integration, potential ethical challenges, and the multistage path to clinical translation. Despite these challenges, advanced epilepsy neurotechnologies offer the potential to improve our understanding of the underlying causes of epilepsy and our capacity to provide patient‐specific treatment.

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