Subacute effects of deep-sea water from the Japan Sea on blood examination values in mice

Abstract

Objectives: To clarify the characteristics of deep-sea water (DSW), we investigated the hematological, immunological and biochemical effects of DSW, specifically the so-called Japan Sea Proper Water (JSPW), samples of which we collected from the Japan Sea at a depth of about 300 meters.Methods: Five groups of five mice each were orally administered, ad libitum for 12 weeks, one of the following: 1.2% DSW, 12% DSW, 1.2% surface-sea water (SSW), 12% SSW, or purified water (control).Results: Among these groups, no significant differences were observed in the average reduction of water intake, food consumption or body weight. The mean corpuscular volume, however, was significantly lower (p<0.05) in the 1.2% DSW group than in the control group. Moreover, serum immunoglobulin G and A values were significantly higher (p<0.05) in the 12% DSW and the 12% SSW groups, respectively, compared with the control group. In addition, the serum glucose value in the 12% DSW group was significantly higher (p<0.05) than in the control group.Conclusions: The findings of the present study suggested the presence of some toxic components in DSW. Before a final answer is reached about whether DSW, and specifically JSPW, is bad for human health, the pathophysiology of findings such as the decreased mean corpuscular volume, the higher immunoglobulin G value and the higher glucose value should be investigated.

Effect of Minerals on Intestinal IgA Production Using Deep Sea Water Drinks

“…34) Both effects are thought to be caused by the minerals contained in deep sea water. These results add new knowledge to deep sea water's immune system-related functions via the augmentation of IgA secretion; this could be considered as an activation of the adaptive immune defense's humoral response caused by deep sea water.Further research is needed on the relation between Peyer's patch immune function control and minerals.…”

Effects of Desalted Deep Sea water on Hematologic and Blood Chemical Values in Mice

“…To promote the effective utilization of DSW collected from the Sea of Japan, we have been conducting research on applications of DSW in terms of health care and health promotion (Tsuchiya et al 2002(Tsuchiya et al , 2003a. Our previous study revealed that serum concentrations of IgG and glucose in mice increased significantly 12 weeks after the administration of the 12% DSW diluted with purified water, compared with those administered purified water.…”