Subacute alcohol and/or disulfiram intake affects bioelements and redox status in rat testes

Djurić, Ana; Begić, Aida; Gobeljić, Borko; Pantelić, Ana; Zebić, Goran; Stevanović, Ivana; Djurdjević, Dragan; Ninković, Milica; Prokić, Vera; Stanojević, Ivan; Vojvodić, Danilo; Djukić, Mirjana

doi:10.1016/j.fct.2017.03.041

Cited by 2 publications

(3 citation statements)

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“…Excessive ethanol exposure had an effect on the biology and redox homeostasis of the testes (Djuric et al, 2017). It was suggested that alcohol consumption is harmful to testicular pathology and sperm parameters (La Vignera, Condorelli, Balercia, Vicari, & Calogero, 2013), and restraint‐induced stress could aggravate alcohol‐induced reproductive toxicity in rats (Priya, Girish, & Reddy, 2014).…”

Section: Discussionmentioning

confidence: 99%

Lycium barbarum polysaccharide protects against ethanol‐induced spermiotoxicity and testicular degeneration in Immp2l ^+/− mice

Liu

et al. 2020

Andrologia

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Studies have indicated that high levels of ethanol exposure impaired spermatogenesis in mice. However, the effects of chronic and low‐dose alcohol consumption on susceptible populations remain unclear. The previous studies have confirmed that Immp2l mutant mice (Immp2lTg(Tyr)979Ove or Immp2l−/−) suffered from increased levels of oxidative stress(OS) and male infertility, heterozygous lmmp2l mice (Immp2l+/−) showed no altered ROS levels under physiological condition. Lycium barbarum polysaccharide (LBP) significantly scavenge oxygen free radicals and enhance antioxidant enzyme activity. The objectives of present study were to research the effects of chronic and low‐dose alcohol‐induced damage on Immp2l+/−, explore the protective function of LBP and possible mechanism. The results indicated that chronic ethanol exposure leads to spermatogenic impairment and triggered a toxic effect on germ cell, 10 mg/kg LBP administration improved the quality of spermatozoon, decreased the ratio of apoptotic germ cells and the expression of Col1a1 and Col1a2, while increased the level of TNP2 and RPL31. In conclusion, the study may provide basic knowledge about LBP’s important role against ethanol‐induced spermiotoxicity and testicular degeneration in Immp2l+/− mice, and the mechanism may be that LBP influenced the state of the spermatogenic epithelium by decreasing the expression of Collagen level leading to alterations in protein biosynthesis during the process of spermatogenesis.

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Section: Discussionmentioning

confidence: 99%

Lycium barbarum polysaccharide protects against ethanol‐induced spermiotoxicity and testicular degeneration in Immp2l ^+/− mice

Liu

et al. 2020

Andrologia

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“…According to our results, prolonged exposure of rats to Cd significantly reduced the activities of testicular GR, tGST and GSH (which is also supported by the noted high GSSG/GSH ratio). Administration of DSF affected tGST activity [31]. However, tGST activity can be restored by an excess of GSH [38].…”

Section: Discussionmentioning

confidence: 95%

“…DSF-like thiols of low molecular weight (such as D-penicillamine, N-acetylcysteine, captopril, tetrathiomolybdate) demonstrate both antioxidant and prooxidant effects [30,31]. Therefore, agents that can reduce or increase oxidative conditions, such as DSF or DSF-like thiols, have been considered as OS modulators [32].…”

Section: Discussionmentioning

confidence: 99%

Disulfiram partially improves oxidative but not androgen status in rats exposed to cadmium

Pavlović

Đurić

Stevanović

et al. 2019

ARCH BIOL SCI BELGRA

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We investigated the effect of disulfiram (DSF) on reproductive toxicity induced by subchronic exposure to cadmium (Cd). We examined the redox status and systemic testosterone changes in the testes and plasma of Cd-treated male Wistar rats. Rats were treated with 1 mg CdCl 2 /kg body weight (bw)/day (intraperitoneal administration) for 42 days; in the second experimental group, rats were given 178.5 mg DSF/kg bw/day by oral gavage for 21 days; in the third group, after administration of Cd for 21 days, DSF treatment was introduced on day 22 and lasted until day 42, with continuous Cd intake. Each experimental group had a matching control: untreated rats, rats that received for 21 days olive oil, the solvent for DSF; rats that started with olive oil intake from days 22-42. Exposure of rats to DSF modulated the oxidative status in the testes; thus, coexposure increased the Cd-induced reduction in total superoxide dismutase (tSOD), catalase (CAT), glutathione reductase (GR) and total glutathione-S-transferase (tGST) activities, and lowered the Cd-increased superoxide anion radical (O 2 •-) and malondialdehyde (MDA) concentrations. DSF did not affect testosterone production diminished by Cd, as Leydig cells, once impaired by Cd, could not be reactivated by DSF.

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Subacute alcohol and/or disulfiram intake affects bioelements and redox status in rat testes

Cited by 2 publications

References 41 publications

Lycium barbarum polysaccharide protects against ethanol‐induced spermiotoxicity and testicular degeneration in Immp2l ^+/− mice

Lycium barbarum polysaccharide protects against ethanol‐induced spermiotoxicity and testicular degeneration in Immp2l ^+/− mice

Disulfiram partially improves oxidative but not androgen status in rats exposed to cadmium

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Subacute alcohol and/or disulfiram intake affects bioelements and redox status in rat testes

Cited by 2 publications

References 41 publications

Lycium barbarum polysaccharide protects against ethanol‐induced spermiotoxicity and testicular degeneration in Immp2l +/− mice

Lycium barbarum polysaccharide protects against ethanol‐induced spermiotoxicity and testicular degeneration in Immp2l +/− mice

Disulfiram partially improves oxidative but not androgen status in rats exposed to cadmium

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Lycium barbarum polysaccharide protects against ethanol‐induced spermiotoxicity and testicular degeneration in Immp2l ^+/− mice

Lycium barbarum polysaccharide protects against ethanol‐induced spermiotoxicity and testicular degeneration in Immp2l ^+/− mice