Sub-acute effects of diazinon on biochemical indices and specific biomarkers in rats: Protective effects of crocin and safranal

Hariri, Alireza Timcheh; Moallem, Seyed Adel; Mahmoudi, Mahmoud; Memar, Bahram; Hosseinzadeh, Hossein

doi:10.1016/j.fct.2010.07.010

Cited by 133 publications

(79 citation statements)

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“…Simillar results were obtained by ElShenawy et al, 77 Hariri et al, 78 who found elevation of urea and creatinine in rats treated with diazinon. Also, he reported the ability of Vitamin E to decrease these parameters.…”

supporting

confidence: 74%

Ameliorative Effect of Lycopene and Vitamin E on Some Haematological and Biochemical Parameters of Oreochromis niloticus Against Diazinon Toxicity

Ibrahim¹

2014

APAR

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The present investigation aimed to determine the toxicological effects of diazinon (DZN) pesticide on hematological and biochemical parameters of the widely consumed Oreochromis niloticus. Adult specimens of Oreochromis niloticus were exposed to two sublethal concentrations (0.76 and 2.3mg/l) of DZN against the ameliorative effect of lycopene (10mg/kg) and vitamin E (50mg/kg) for 14 and 28 days. Empirical data of results obtained were subjected to statistical analysis of variance (ANOVA) to test the effects of DZN, lycopene (LYC), vitamin E (VE) and exposure periods. DZN significantly led to decline in red blood cell count (RBC's), blood haemoglobin (Hb), haematocrit value (Hct), white blood cell count (WBC's) and lymphocytes (LYM). While, the mean values of mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH), mean corpuscular haemoglobin concentration (MCHC), neutrophils (NEU), monocytes (MON), eosinophils (EOS), serum protein (total protein, albumin and globulin), glucose, AST, ALT, ALP, urea and creatinine were significantly increased from the control values. Lycopene and vitamin E supplementation play appositive role in detoxification of DZN toxicity. The results suggest that DZN can negatively affect the hematology and physiology of fish. It was observed that supplementation of lycopene and vitamin E decreases the toxic effect of diazinon. Keywords

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confidence: 74%

Ameliorative Effect of Lycopene and Vitamin E on Some Haematological and Biochemical Parameters of Oreochromis niloticus Against Diazinon Toxicity

Ibrahim¹

2014

APAR

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“…Long term administration of diazinon in rabbits induced significant oxidative DNA damage in the liver and kidney and significantly reduced plasma CAT, GSH and TAC levels (Tsitsimpikou et al 2013). The levels of serum TNF-a, uric acid, LDH, AST, ALT were significantly increased by sub-acute administration of diazinon in rats (Hariri et al 2010). …”

Section: Discussionmentioning

confidence: 97%

“…The 2nd and 3rd groups were given CTX (100 mg/kg bw SC) (Amin et al 2012) and ascorbic acid (100 mg/kg bw orally) ) daily for 4 weeks. The 4th group received a daily dose of DZN (20 mg/kg, SC) (Hariri et al 2010). The 5th and 6th groups were given CTX and AA at the same dose regimen used for the 2nd and 3rd groups before DZN administration at the same dose and regimen used for the 4th group.…”

Section: Animals and Experimental Designmentioning

confidence: 99%

Synergistic protective role of ceftriaxone and ascorbic acid against subacute diazinon-induced nephrotoxicity in rats

Abdel-Daim

2014

Cytotechnology

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Diazinon (DZN) is a synthetic organophosphrus acaricide and insecticide widely used for veterinary and agricultural purposes. However, its animal and human exposure leads to nephrotoxicity. Our experimental objective was to evaluate protective effects of ceftriaxone and/or ascorbic acid-vitamin C against DZN-induced renal injury in male Wistar albino rats. DZN-treated animals revealed significant elevation in serum biochemical parameters related to renal injury: urea, uric acid and creatinine. DZN intoxication significantly increased renal lipid peroxidation, and significant inhibition in antioxidant biomarkers including, reduced glutathione, glutathione peroxidase, superoxide dismutase, catalase and total antioxidant capacity. In addition, DZN significantly reduced serum acetylcholinestrase level. Moreover, It induced serum and kidney tumor necrosis factor-a level. Both ceftriaxone and vitamin C protect against DZN-induced serum as well as renal tissue biochemical parameters when used alone or in combination along with DZN-intoxication. Furthermore, both ceftriaxone and vitamin C produced synergetic nephroprotective and antioxidant effects. Therefore, it could be concluded that ceftriaxone and/or vitamin C administration are able to minimize the toxic effects of DZN by its free radical-scavenging and potent antioxidant activity.

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“…[20,32,33] Corresponded previous studies have demonstrated increased levels of pro-inflammatory cytokines in rats exposed to organophosphates. [20,32,34,35] In addition, it has been demonstrated that the peripheral administration of interleukin-6 induces hyperglycemia and insulin resistance in humans and rodents. [36] A recent study hypothesized that organophosphate pesticides can attenuate the incretin effect and produce insulin resistance through lipotoxic effects, inflammatory stimulation, and the induction of oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

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Sudjaroen

2017

AJP

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Background: Main of agriculturists in Singburi was cultivated rice and major pesticides' use is chlorpyrifos; however, farmers are applied bio-extracts to eliminate pest and trend to be organic farming. Hence, organic farmers may become lower risks from pesticides rather than non-organic farmers. Aim: To determine biochemical and hematological status between organic and non-organic farmers, Bang Rachan district, Singburi, Thailand. Materials and Methods: Farmers were separated into organic farmer group (N = 35) and non-organic farmer group (N = 45). Individual data for pesticide exposure were included, and pesticide-exposed relating symptoms were recorded. All demographic data of participants were documented before blood collection. Serum samples were analyzed for butyrylcholinesterase (BuChE) activity, liver function test, kidney function test, and lipid profiles. Each ethylenediaminetetraacetic acid-whole blood was determined for complete blood count (CBC). NaF plasma was analyzed for determine fasting blood glucose. All biochemical parameters were principled according to enzymatic assays and CBC was automatic analyzers. The data were represented in average ± standard deviation, and difference of biochemical and hematological status of two groups was statistically tested by unpaired t-test (P < 0.05). Results and Discussion: Blood glucose and lipid profiles of non-organic farmers were higher than reference ranges and significantly difference with other groups. Mean corpuscular hemoglobin (MCH) and MCH concentration values of non-organic farmers were lower than reference range and interpreted as anemia. Conclusions: Non-organic farmers were suchronic pesticide exposure with normal BuChE values and no related symptom; therefore, subclinical symptoms were disturbed biochemical and hematological status; and prediabetes, dyslipidemia, and anemia appeared.

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Sub-acute effects of diazinon on biochemical indices and specific biomarkers in rats: Protective effects of crocin and safranal

Cited by 133 publications

References 42 publications

Ameliorative Effect of Lycopene and Vitamin E on Some Haematological and Biochemical Parameters of Oreochromis niloticus Against Diazinon Toxicity

Ameliorative Effect of Lycopene and Vitamin E on Some Haematological and Biochemical Parameters of Oreochromis niloticus Against Diazinon Toxicity

Synergistic protective role of ceftriaxone and ascorbic acid against subacute diazinon-induced nephrotoxicity in rats

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